PMID- 33851516
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20220401
IS  - 1932-846X (Electronic)
IS  - 1932-8451 (Print)
IS  - 1932-8451 (Linking)
VI  - 81
IP  - 5
DP  - 2021 Jul
TI  - Persistent organic pollutants at the synapse: Shared phenotypes and converging 
      mechanisms of developmental neurotoxicity.
PG  - 623-652
LID - 10.1002/dneu.22825 [doi]
AB  - The developing nervous system is sensitive to environmental and physiological 
      perturbations in part due to its protracted period of prenatal and postnatal 
      development. Epidemiological and experimental studies link developmental 
      exposures to persistent organic pollutants (POPs) including polychlorinated 
      biphenyls, polychlorinated dibenzo-p-dioxins, polybrominated diphenyl ethers, and 
      benzo(a)pyrene to increased risk for neurodevelopmental disorders in children. 
      Mechanistic studies reveal that many of the complex cellular processes that occur 
      during sensitive periods of rapid brain development are cellular targets for 
      developmental neurotoxicants. One area of research interest has focused on 
      synapse formation and plasticity, processes that involve the growth and 
      retraction of dendrites and dendritic spines. For each chemical discussed in this 
      review, we summarize the morphological and electrophysiological data that provide 
      evidence that developmental POP exposure produces long-lasting effects on 
      dendritic morphology, spine formation, glutamatergic and GABAergic signaling 
      systems, and synaptic transmission. We also discuss shared intracellular 
      mechanisms, with a focus on calcium and thyroid hormone homeostasis, by which 
      these chemicals act to modify synapses. We conclude our review highlighting 
      research gaps that merit consideration when characterizing synaptic pathology 
      elicited by chemical exposure. These gaps include low-dose and nonmonotonic 
      dose-response effects, the temporal relationship between dendritic growth, spine 
      formation, and synaptic activity, excitation-inhibition balance, hormonal 
      effects, and the need for more studies in females to identify sex differences. By 
      identifying converging pathological mechanisms elicited by POP exposure at the 
      synapse, we can define future research directions that will advance our 
      understanding of these chemicals on synapse structure and function.
CI  - (c) 2021 Wiley Periodicals, LLC.
FAU - Latchney, Sarah E
AU  - Latchney SE
AUID- ORCID: 0000-0002-4070-1165
AD  - Department of Biology, St. Mary's College of Maryland, St. Mary's City, MD, USA.
AD  - Department of Neuroscience, Del Monte Institute for Neuroscience, University of 
      Rochester Medical Center, Rochester, NY, USA.
FAU - Majewska, Ania K
AU  - Majewska AK
AUID- ORCID: 0000-0002-2167-6849
AD  - Department of Neuroscience, Del Monte Institute for Neuroscience, University of 
      Rochester Medical Center, Rochester, NY, USA.
AD  - Center for Visual Science, University of Rochester Medical Center, Rochester, NY, 
      USA.
LA  - eng
GR  - R01 AA027111/AA/NIAAA NIH HHS/United States
GR  - P30 ES001247/ES/NIEHS NIH HHS/United States
GR  - R01 NS114480/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20210502
PL  - United States
TA  - Dev Neurobiol
JT  - Developmental neurobiology
JID - 101300215
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - *Neurotoxicity Syndromes
MH  - Persistent Organic Pollutants
MH  - Phenotype
MH  - *Polychlorinated Biphenyls/toxicity
MH  - Pregnancy
MH  - Synapses
PMC - PMC8364477
MID - NIHMS1700230
OTO - NOTNLM
OT  - dendrites
OT  - dendritic spines
OT  - low-dose effects
OT  - neurodevelopment
OT  - synaptic plasticity
COIS- Conflict of interest statement: The authors declare they have no competing 
      financial interests.
EDAT- 2021/04/15 06:00
MHDA- 2022/04/01 06:00
PMCR- 2021/08/15
CRDT- 2021/04/14 06:52
PHST- 2021/02/27 00:00 [revised]
PHST- 2020/10/10 00:00 [received]
PHST- 2021/04/09 00:00 [accepted]
PHST- 2021/04/15 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
PHST- 2021/04/14 06:52 [entrez]
PHST- 2021/08/15 00:00 [pmc-release]
AID - 10.1002/dneu.22825 [doi]
PST - ppublish
SO  - Dev Neurobiol. 2021 Jul;81(5):623-652. doi: 10.1002/dneu.22825. Epub 2021 May 2.