PMID- 33851527
OWN - NLM
STAT- MEDLINE
DCOM- 20211123
LR  - 20211204
IS  - 2191-0251 (Electronic)
IS  - 0334-018X (Linking)
VI  - 34
IP  - 5
DP  - 2021 May 26
TI  - Anthropometric, biochemical and hormonal profiles of the partially admixed 
      pygmoid group in Rampasasa (Flores, Indonesia).
PG  - 547-557
LID - 10.1515/jpem-2020-0526 [doi]
AB  - OBJECTIVES: We performed a cross-sectional study on anthropometric and laboratory 
      characteristics of inhabitants of Rampasasa (Flores, Indonesia). Adults were 
      categorised according to ancestry into three groups: pygmoid (P/P, offspring of 
      pygmoid parents, n=8), mixed pygmoid (P/N, offspring of pygmoid and non-pygmoid 
      parents, n=12) and non-pygmoid (N/N, n=10). Children (n=28) were P/N. METHODS: 
      Measurements included height, weight, sitting height, arm span, head 
      circumference, haematological analysis and serum albumin, calcium, vitamin D, 
      insulin-like growth factor-I (IGF-I) and IGF binding protein 3 (IGFBP-3). 
      Pubertal stage and bone age was assessed in children. Anthropometric data were 
      expressed as standard deviation score (SDS) for age. IGF-I, IGFBP-3 and 
      IGF-I/IGFBP-3 ratio were expressed as SDS for age, bone age and pubertal stage. 
      RESULTS: Mean height SDS showed a gradient from P/P (-4.0) via P/N (-3.2) to N/N 
      (-2.3) (-3.4, -3.1 and -2.2 adjusted for age-associated shrinking). Sitting 
      height and head circumference showed similar gradients. Serum IGF-I SDS was 
      similar among groups (approximately -1 SDS). IGFBP-3 SDS tended toward a gradient 
      from P/P (-1.9) via P/N (-1.5) to N/N (-1.1), but IGF-I/IGFBP-3 ratio was normal 
      in all groups. In P/P and P/N, mean head circumference SDS was >2 SD greater than 
      mean height SDS. Children showed a progressive growth failure and bone age delay, 
      delayed female pubertal onset and an initial low serum IGF-I, normal IGFBP-3 and 
      low IGF-I/IGFBP-3 ratio. CONCLUSIONS: P/P showed proportionate short stature with 
      relative macrocephaly and relatively low IGFBP-3; P/N presented an intermediate 
      pattern. P/N children were progressively short, showed delayed skeletal 
      maturation, delayed puberty in girls and low IGF-I and IGF-I/IGFBP-3.
CI  - (c) 2021 Walter de Gruyter GmbH, Berlin/Boston.
FAU - Pulungan, Aman
AU  - Pulungan A
AUID- ORCID: 0000-0003-4895-4105
AD  - Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto 
      Mangunkusumo Hospital, Jakarta, Indonesia.
FAU - Andarie, Attika A
AU  - Andarie AA
AUID- ORCID: 0000-0002-0114-0676
AD  - Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
FAU - Soesanti, Frida
AU  - Soesanti F
AUID- ORCID: 0000-0002-4319-5528
AD  - Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto 
      Mangunkusumo Hospital, Jakarta, Indonesia.
FAU - Yassien, Muhammad Ramdhani
AU  - Yassien MR
AUID- ORCID: 0000-0001-8765-7352
AD  - Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto 
      Mangunkusumo Hospital, Jakarta, Indonesia.
FAU - de Bruin, Christiaan
AU  - de Bruin C
AUID- ORCID: 0000-0003-1478-2261
AD  - Department of Pediatrics, Leiden University Medical Center, Leiden, Netherlands.
FAU - Wijaya, Andi
AU  - Wijaya A
AUID- ORCID: 0000-0003-3986-6285
AD  - Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia.
FAU - Firmansyah, Agus
AU  - Firmansyah A
AUID- ORCID: 0000-0002-3236-0014
AD  - Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto 
      Mangunkusumo Hospital, Jakarta, Indonesia.
FAU - Wit, Jan M
AU  - Wit JM
AUID- ORCID: 0000-0002-1715-5020
AD  - Department of Pediatrics, Leiden University Medical Center, Leiden, Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20210413
PL  - Germany
TA  - J Pediatr Endocrinol Metab
JT  - Journal of pediatric endocrinology & metabolism : JPEM
JID - 9508900
RN  - 0 (IGFBP3 protein, human)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adult
MH  - Anthropometry
MH  - *Body Mass Index
MH  - *Body Weight
MH  - Bone Diseases/*epidemiology/metabolism/pathology
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Ethnicity/*statistics & numerical data
MH  - Female
MH  - Follow-Up Studies
MH  - Growth Disorders/*epidemiology/metabolism/pathology
MH  - Humans
MH  - Indonesia/epidemiology
MH  - Infant
MH  - Infant, Newborn
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Prognosis
OTO - NOTNLM
OT  - IGF-I
OT  - IGFBP-3
OT  - growth
OT  - head circumference
OT  - negritos
OT  - pygmies
OT  - short stature
OT  - vitamin D deficiency
EDAT- 2021/04/15 06:00
MHDA- 2021/11/24 06:00
CRDT- 2021/04/14 06:53
PHST- 2020/09/11 00:00 [received]
PHST- 2020/11/22 00:00 [accepted]
PHST- 2021/04/15 06:00 [pubmed]
PHST- 2021/11/24 06:00 [medline]
PHST- 2021/04/14 06:53 [entrez]
AID - jpem-2020-0526 [pii]
AID - 10.1515/jpem-2020-0526 [doi]
PST - epublish
SO  - J Pediatr Endocrinol Metab. 2021 Apr 13;34(5):547-557. doi: 
      10.1515/jpem-2020-0526. Print 2021 May 26.