PMID- 33853078
OWN - NLM
STAT- MEDLINE
DCOM- 20210805
LR  - 20210805
IS  - 1423-0275 (Electronic)
IS  - 0301-1569 (Linking)
VI  - 83
IP  - 4
DP  - 2021
TI  - Thyroid Dysfunction in Meniere's Disease: A Comprehensive Review.
PG  - 219-226
LID - 10.1159/000514792 [doi]
AB  - INTRODUCTION: The precise etiology of Meniere's disease (MD) remains unknown; 
      however, given the association of MD with serum antibodies and human leukocyte 
      antigen (HLA) complex, several studies have proposed a relationship between MD 
      and thyroid disorders. Similarly, multiple hypotheses exist regarding the 
      metabolic disturbances of fluctuating thyroid hormone as a potential contributing 
      agent in the development of MD. METHODS: A total of 171 abstracts were identified 
      and screened by 2 independent reviewers. Based on inclusion and exclusion 
      criteria, 8 studies were selected for final analysis. Due to heterogeneity of 
      clinical data, meta-analysis was not feasible. RESULTS: The prevalence of 
      autoimmune thyroid disease and hypothyroidism in MD varied significantly from 1 
      to 38%. Notable bias was introduced given the lack of standardization of 
      diagnostic criteria across studies. Articles that described autoimmune 
      thyroid-specific antibodies and HLA types also presented inconclusive results. 
      Multiple studies noted a potential etiologic role of hypothyroidism in MD, which 
      was often confounded by thyroxine supplementation. CONCLUSIONS: Despite a 
      potential correlation in the medical literature between thyroid disorders and MD, 
      there is currently no definitive causal relationship. Although most of the 
      present medical literature focuses on autoimmunity, dysregulated thyroid hormone 
      levels may also be implicated in the association of MD with thyroid disorders.
CI  - (c) 2021 S. Karger AG, Basel.
FAU - Hwang, Gloria
AU  - Hwang G
AD  - College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania, 
      USA.
FAU - Saadi, Robert
AU  - Saadi R
AD  - Department of Otolaryngology, Head and Neck Surgery, College of Medicine, The 
      Pennsylvania State University, Hershey, Pennsylvania, USA.
FAU - Patel, Vijay A
AU  - Patel VA
AD  - Department of Otolaryngology, Head and Neck Surgery, College of Medicine, The 
      Pennsylvania State University, Hershey, Pennsylvania, USA.
FAU - Liaw, Jeffrey
AU  - Liaw J
AD  - Department of Otolaryngology, Head and Neck Surgery, College of Medicine, The 
      Pennsylvania State University, Hershey, Pennsylvania, USA.
FAU - Isildak, Huseyin
AU  - Isildak H
AD  - Department of Otolaryngology, Head and Neck Surgery, College of Medicine, The 
      Pennsylvania State University, Hershey, Pennsylvania, USA.
LA  - eng
PT  - Systematic Review
DEP - 20210414
PL  - Switzerland
TA  - ORL J Otorhinolaryngol Relat Spec
JT  - ORL; journal for oto-rhino-laryngology and its related specialties
JID - 0334721
SB  - IM
MH  - Humans
MH  - *Meniere Disease/complications/epidemiology
MH  - Prevalence
MH  - *Thyroid Diseases/complications/epidemiology
OTO - NOTNLM
OT  - Autoimmune
OT  - Hypothyroidism
OT  - Meniere's disease
OT  - Otology
OT  - Sensorineural hearing loss
OT  - Thyroid
OT  - Update
EDAT- 2021/04/15 06:00
MHDA- 2021/08/06 06:00
CRDT- 2021/04/14 20:16
PHST- 2019/11/22 00:00 [received]
PHST- 2021/01/27 00:00 [accepted]
PHST- 2021/04/15 06:00 [pubmed]
PHST- 2021/08/06 06:00 [medline]
PHST- 2021/04/14 20:16 [entrez]
AID - 000514792 [pii]
AID - 10.1159/000514792 [doi]
PST - ppublish
SO  - ORL J Otorhinolaryngol Relat Spec. 2021;83(4):219-226. doi: 10.1159/000514792. 
      Epub 2021 Apr 14.