PMID- 33853410
OWN - NLM
STAT- MEDLINE
DCOM- 20211119
LR  - 20220415
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 41
IP  - 10
DP  - 2021 Oct
TI  - Neurovascular coupling dysfunction in end-stage renal disease patients related to 
      cognitive impairment.
PG  - 2593-2606
LID - 10.1177/0271678X211007960 [doi]
AB  - We aimed to investigate the neurovascular coupling (NVC) dysfunction in end-stage 
      renal disease (ESRD) patients related with cognitive impairment. Twenty-five ESRD 
      patients and 22 healthy controls were enrolled. To assess the NVC dysfunctional 
      pattern, resting-state functional MRI and arterial spin labeling were explored to 
      estimate the coupling of spontaneous neuronal activity and cerebral blood 
      perfusion based on amplitude of low-frequency fluctuation (ALFF)-cerebral blood 
      flow (CBF), fractional ALFF (fALFF)-CBF, regional homogeneity (ReHo)-CBF, and 
      degree centrality (DC)-CBF correlation coefficients. Multivariate partial 
      least-squares correlation and mediation analyses were used to evaluate the 
      relationship among NVC dysfunctional pattern, cognitive impairment and clinical 
      characteristics. The NVC dysfunctional patterns in ESRD patients were 
      significantly decreased in 34 brain regions compared with healthy controls. The 
      decreased fALFF-CBF coefficients in the cingulate gyrus (CG) were associated 
      positively with lower kinetic transfer/volume urea (Kt/V) and lower short-term 
      memory scores, and were negatively associated with higher serum urea. The 
      relationship between Kt/V and memory deficits of ESRD patients was partially 
      mediated by the fALFF-CBF alteration of the CG. These findings reveal the NVC 
      dysfunction may be a potential neural mechanism for cognitive impairment in ESRD. 
      The regional NVC dysfunction may mediate the impact of dialysis adequacy on 
      memory function.
FAU - Li, Peng
AU  - Li P
AD  - Department of Medical Imaging, First Affiliated Hospital of Xi'an, Jiaotong 
      University, Xi'an, China.
AD  - Department of Medical Imaging, Hospital of Shaanxi Nuclear Geology, Xianyang, 
      China.
FAU - Mu, Junya
AU  - Mu J
AD  - Center for Brain Imaging, School of Life Science and Technology, Xidian 
      University, Xi'an, China.
FAU - Ma, Xueying
AU  - Ma X
AD  - Department of Medical Imaging, The Affiliated Hospital of Inner Mongolia Medical 
      University, Hohhot, China.
FAU - Ding, Dun
AU  - Ding D
AD  - Department of Medical Imaging, The Second Affiliated Hospital of Xi'an, Jiaotong 
      University, Xi'an, China.
FAU - Ma, Shaohui
AU  - Ma S
AD  - Department of Medical Imaging, First Affiliated Hospital of Xi'an, Jiaotong 
      University, Xi'an, China.
FAU - Zhang, Huawen
AU  - Zhang H
AD  - Department of Medical Imaging, Hospital of Shaanxi Nuclear Geology, Xianyang, 
      China.
FAU - Liu, Jixin
AU  - Liu J
AD  - Center for Brain Imaging, School of Life Science and Technology, Xidian 
      University, Xi'an, China.
FAU - Zhang, Ming
AU  - Zhang M
AD  - Department of Medical Imaging, First Affiliated Hospital of Xi'an, Jiaotong 
      University, Xi'an, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210414
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
SB  - IM
MH  - Adult
MH  - Cognitive Dysfunction/*physiopathology
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/*complications/physiopathology
MH  - Male
MH  - Neurovascular Coupling/*physiology
PMC - PMC8504946
OTO - NOTNLM
OT  - End-stage renal disease
OT  - arterial spin labeling
OT  - cognitive impairment
OT  - functional magnetic resonance imaging
OT  - neurovascular coupling
COIS- Declaration of conflicting interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2021/04/16 06:00
MHDA- 2021/11/20 06:00
PMCR- 2022/04/14
CRDT- 2021/04/15 05:34
PHST- 2021/04/16 06:00 [pubmed]
PHST- 2021/11/20 06:00 [medline]
PHST- 2021/04/15 05:34 [entrez]
PHST- 2022/04/14 00:00 [pmc-release]
AID - 10.1177_0271678X211007960 [pii]
AID - 10.1177/0271678X211007960 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2021 Oct;41(10):2593-2606. doi: 
      10.1177/0271678X211007960. Epub 2021 Apr 14.