PMID- 33854388
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220422
IS  - 1179-1594 (Print)
IS  - 1179-1594 (Electronic)
IS  - 1179-1594 (Linking)
VI  - 14
DP  - 2021
TI  - Vitamin D Status is Independently Associated with Insulin Resistance in Patients 
      with Type 2 Diabetes Mellitus.
PG  - 1393-1399
LID - 10.2147/RMHP.S299963 [doi]
AB  - PURPOSE: This study aimed to examine whether 25-hydroxyvitamin D (25OHD) levels 
      (an indicator of vitamin D status) are independently associated with insulin 
      resistance (IR) in patients with type 2 diabetes mellitus (T2DM). PATIENTS AND 
      METHODS: This was a cross-sectional study. Participants with T2DM were recruited 
      from the Department of Endocrinology in Hebei General Hospital according to 
      inclusion and exclusion criteria. Data on basic characteristics and blood 
      parameters were collected. We used the IR index (20/[fasting C-peptide x fasting 
      plasma glucose]) to evaluate IR. Potential confounding factors were selected from 
      comparisons among different IR index groups of quartiles and were adjusted in 
      different models. RESULTS: We included 172 subjects (121 men and 51 women) whose 
      mean age was 53.2+/-10.6 years. Body mass index (BMI), DM course, insulin use, 
      glycated hemoglobin (HbA1c), fasting blood glucose, fasting C-peptide, 
      triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apolipoprotein 
      A1 (ApoA1), and albumin were differed among different IR-index groups (all P 
      value <0.05). In models 1 and 2, no or some confounding factors were adjusted 
      for, and we found that there was no relationship between 25OHD and the IR index. 
      In model 3, when all confounding factors (DM course, insulin use, BMI, HbA1c, TG, 
      HDL-C, ApoA1, albumin and other bone turnover markers) were adjusted for, the IR 
      index was increased by 5.6% when 25OHD levels increased by 1 ng/mL (odds ratio: 
      1.056; 95% confidence interval: 1.009, 1.105). CONCLUSION: Vitamin D is 
      independently associated with IR in patients with T2DM.
CI  - (c) 2021 Zhao et al.
FAU - Zhao, Hang
AU  - Zhao H
AUID- ORCID: 0000-0002-9531-7574
AD  - Endocrinology Department, Hebei General Hospital, Shijiazhuang, Hebei, 050051, 
      People's Republic of China.
FAU - Tang, Yong
AU  - Tang Y
AD  - Endocrinology Department, Hebei General Hospital, Shijiazhuang, Hebei, 050051, 
      People's Republic of China.
FAU - Zheng, Chong
AU  - Zheng C
AD  - Pediatric Orthopaedics, Shijiazhuang the Third Hospital, Shijiazhuang, Hebei, 
      050011, People's Republic of China.
FAU - Ren, Luping
AU  - Ren L
AD  - Endocrinology Department, Hebei General Hospital, Shijiazhuang, Hebei, 050051, 
      People's Republic of China.
FAU - Song, Guangyao
AU  - Song G
AD  - Endocrinology Department, Hebei General Hospital, Shijiazhuang, Hebei, 050051, 
      People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20210407
PL  - England
TA  - Risk Manag Healthc Policy
JT  - Risk management and healthcare policy
JID - 101566264
PMC - PMC8039193
OTO - NOTNLM
OT  - diabetes mellitus
OT  - insulin resistance
OT  - type 2
OT  - vitamin D
COIS- The authors report no conflicts of interest related to this work.
EDAT- 2021/04/16 06:00
MHDA- 2021/04/16 06:01
PMCR- 2021/04/07
CRDT- 2021/04/15 07:16
PHST- 2021/01/07 00:00 [received]
PHST- 2021/03/11 00:00 [accepted]
PHST- 2021/04/15 07:16 [entrez]
PHST- 2021/04/16 06:00 [pubmed]
PHST- 2021/04/16 06:01 [medline]
PHST- 2021/04/07 00:00 [pmc-release]
AID - 299963 [pii]
AID - 10.2147/RMHP.S299963 [doi]
PST - epublish
SO  - Risk Manag Healthc Policy. 2021 Apr 7;14:1393-1399. doi: 10.2147/RMHP.S299963. 
      eCollection 2021.