PMID- 33854811
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220422
IS  - 2093-582X (Print)
IS  - 2093-5641 (Electronic)
IS  - 1598-1320 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Mar
TI  - Optimal Timing to Assess Drain Amylase Concentration after Elective Gastrectomy.
PG  - 30-37
LID - 10.5230/jgc.2021.21.e1 [doi]
AB  - PURPOSE: While the amylase concentration of the drainage fluid (dAmy) has been 
      reported to be a predictor of postoperative pancreas-related complications 
      (PPRC), the optimal timing for its measurement has not been fully investigated. 
      MATERIALS AND METHODS: The clinicopathological data of 387 patients who underwent 
      elective gastrectomy for gastric cancer were reviewed. Laboratory data, including 
      dAmy on postoperative days 1 (dAmy1) and 3 (dAmy3), and serum C-reactive protein 
      (sCRP) concentrations on postoperative days 1 (sCRP1) and 3 (sCRP3) were compared 
      between patients with PPRC and without PPRC. RESULTS: Nineteen of the 387 
      patients (4.9%) developed PPRC. The optimal cutoff values of dAmy1, dAmy3, sCRP1, 
      and sCRP3 were 1514 IU/L, 761 IU/L, 8.32 mg/dL, and 15.15 mg/dL, respectively. 
      The area under the curve of dAmy1 was greater than that of dAmy3 (0.915 vs. 
      0.826), and that of sCRP3 was greater than that of sCRP1 (0.820 vs. 0.659). In 
      the multivariate analysis, dAmy1 (P<0.001) and sCRP3 (P=0.004) were significant 
      predictors of PPRC, while dAmy3 (P=0.069) and sCRP1 (P=0.831) were not. Thirteen 
      (41.9%) of 31 patients with both dAmy1 >/=1,545 IU/L and sCRP3 >/=15.15 mg/dL had 
      PPRC >/=Clavien-Dindo II. In contrast, among 260 patients with both dAmy1 <1,545 
      IU/L and sCRP3 <15.15 mg/dL, none developed PPRC. CONCLUSIONS: dAmy1 was more 
      useful than dAmy3 in predicting PPRC. The combination of dAmy1 and sCRP3 may be a 
      useful criterion for the removal of drains on postoperative day 3.
CI  - Copyright (c) 2021. Korean Gastric Cancer Association.
FAU - Wakahara, Tomoyuki
AU  - Wakahara T
AUID- ORCID: 0000-0001-5731-1289
AD  - Department of Surgery, Yodogawa Christian Hospital, Osaka, Japan.
FAU - Kanemitsu, Kiyonori
AU  - Kanemitsu K
AD  - Department of Surgery, Yodogawa Christian Hospital, Osaka, Japan.
FAU - Miura, Susumu
AU  - Miura S
AD  - Department of Surgery, Yodogawa Christian Hospital, Osaka, Japan.
FAU - Tsuchida, Shinobu
AU  - Tsuchida S
AD  - Department of Surgery, Yodogawa Christian Hospital, Osaka, Japan.
FAU - Iwasaki, Takeshi
AU  - Iwasaki T
AD  - Department of Surgery, Yodogawa Christian Hospital, Osaka, Japan.
FAU - Sasako, Mitsuru
AU  - Sasako M
AD  - Department of Surgery, Yodogawa Christian Hospital, Osaka, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210302
PL  - Korea (South)
TA  - J Gastric Cancer
JT  - Journal of gastric cancer
JID - 101559430
PMC - PMC8020000
OTO - NOTNLM
OT  - Amylases
OT  - C-reactive protein
OT  - Gastrectomy
OT  - Pancreatic fistula
OT  - Predictor
COIS- Conflict of Interest: No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2021/04/16 06:00
MHDA- 2021/04/16 06:01
PMCR- 2021/03/01
CRDT- 2021/04/15 07:21
PHST- 2020/10/21 00:00 [received]
PHST- 2020/12/26 00:00 [revised]
PHST- 2021/01/16 00:00 [accepted]
PHST- 2021/04/15 07:21 [entrez]
PHST- 2021/04/16 06:00 [pubmed]
PHST- 2021/04/16 06:01 [medline]
PHST- 2021/03/01 00:00 [pmc-release]
AID - 10.5230/jgc.2021.21.e1 [doi]
PST - ppublish
SO  - J Gastric Cancer. 2021 Mar;21(1):30-37. doi: 10.5230/jgc.2021.21.e1. Epub 2021 
      Mar 2.