PMID- 33855170
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210507
IS  - 2372-3556 (Print)
IS  - 2372-3556 (Electronic)
IS  - 2372-3556 (Linking)
VI  - 8
IP  - 2
DP  - 2021 Mar 9
TI  - p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress 
      control.
PG  - 1890990
LID - 10.1080/23723556.2021.1890990 [doi]
LID - 1890990
AB  - Selective autophagy contributes to the degradation of condensates, such as 
      sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous 
      p62 forms gel-like structures, which serve as platforms for autophagosome 
      formation and nuclear factor erythroid 2-related factor 2 (NRF2) activation. 
      Further, p62-mediated NRF2 activation is not cytotoxic, but combination of NRF2 
      activation with impaired bulk and selective autophagy causes liver injury.
CI  - (c) 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.
FAU - Eskelinen, Eeva-Liisa
AU  - Eskelinen EL
AUID- ORCID: 0000-0003-0006-7785
AD  - Institute of Biomedicine, University of Turku, Turku, Finland.
FAU - Kageyama, Shun
AU  - Kageyama S
AD  - Department of Physiology, Juntendo University Graduate School of Medicine, Tokyo. 
      Japan.
FAU - Komatsu, Masaaki
AU  - Komatsu M
AUID- ORCID: 0000-0001-7672-7722
AD  - Department of Physiology, Juntendo University Graduate School of Medicine, Tokyo. 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20210309
PL  - United States
TA  - Mol Cell Oncol
JT  - Molecular & cellular oncology
JID - 101642411
PMC - PMC8018406
OTO - NOTNLM
OT  - GABARAP
OT  - KEAP1
OT  - LC3
OT  - NRF2
OT  - autophagy
OT  - liquid-liquid phase separation
OT  - oxidative stress
OT  - p62/SQSTM1
EDAT- 2021/04/16 06:00
MHDA- 2021/04/16 06:01
PMCR- 2021/03/09
CRDT- 2021/04/15 07:25
PHST- 2021/04/15 07:25 [entrez]
PHST- 2021/04/16 06:00 [pubmed]
PHST- 2021/04/16 06:01 [medline]
PHST- 2021/03/09 00:00 [pmc-release]
AID - 1890990 [pii]
AID - 10.1080/23723556.2021.1890990 [doi]
PST - epublish
SO  - Mol Cell Oncol. 2021 Mar 9;8(2):1890990. doi: 10.1080/23723556.2021.1890990.