PMID- 33857458
OWN - NLM
STAT- MEDLINE
DCOM- 20210630
LR  - 20220716
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 197
DP  - 2021 Jun
TI  - Exposure to ambient air pollution during pregnancy and inflammatory biomarkers in 
      maternal and umbilical cord blood: The Healthy Start study.
PG  - 111165
LID - S0013-9351(21)00459-X [pii]
LID - 10.1016/j.envres.2021.111165 [doi]
AB  - BACKGROUND: Air pollution exposure during pregnancy has been associated with 
      adverse pregnancy and birth outcomes. Inflammation has been proposed as a 
      potential link. We estimated associations between air pollution exposure during 
      pregnancy and inflammatory biomarkers in maternal and cord blood. We evaluated 
      whether maternal inflammation was associated with infant outcomes. METHODS: Among 
      515 mother-infant dyads in the Healthy Start study (2009-2014), trimester-long, 
      7- and 30-day average concentrations of particulate matter </=2.5 mum (PM(2.5)) and 
      ozone (O(3)) during pregnancy were estimated, using inverse-distance-weighted 
      interpolation. Inflammatory biomarkers were measured in maternal blood in 
      mid-pregnancy (C-reactive protein [CRP], Interleukin [IL]-6, and tumor necrosis 
      factor-alpha [TNFalpha]) and in cord blood at delivery (CRP, IL-6, IL-8, IL-10, monocyte 
      chemoattractant protein-1 [MCP-1], and TNFalpha). We used linear regression to 
      estimate associations between pollutants and inflammatory biomarkers and maternal 
      inflammatory biomarkers and infant weight and body composition. RESULTS: There 
      were positive associations between PM(2.5) during certain exposure periods and 
      maternal IL-6 and TNFalpha. There were negative associations between recent O(3) and 
      maternal CRP, IL-6, and TNFalpha and positive associations between trimester-long 
      O(3) exposure and maternal inflammatory biomarkers, though some 95% confidence 
      intervals included the null. Patterns were inconsistent for associations between 
      PM(2.5) and O(3) and cord blood inflammatory biomarkers. No consistent 
      associations between maternal inflammatory biomarkers and infant outcomes were 
      identified. CONCLUSIONS: Air pollution exposure during pregnancy may impact 
      maternal inflammation. Further investigations should examine the health 
      consequences for women and infants of elevated inflammatory biomarkers associated 
      with air pollution exposure during pregnancy.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Friedman, Chloe
AU  - Friedman C
AD  - Department of Epidemiology, Colorado School of Public Health, University of 
      Colorado Anschutz Medical Campus, Aurora, CO, USA; Lifecourse Epidemiology of 
      Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical 
      Campus, Aurora, CO, USA. Electronic address: chloe.friedman@cuanschutz.edu.
FAU - Dabelea, Dana
AU  - Dabelea D
AD  - Department of Epidemiology, Colorado School of Public Health, University of 
      Colorado Anschutz Medical Campus, Aurora, CO, USA; Lifecourse Epidemiology of 
      Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical 
      Campus, Aurora, CO, USA; Department of Pediatrics, School of Medicine, University 
      of Colorado Anschutz Medical Campus, Aurora, CO, USA.
FAU - Thomas, Deborah S K
AU  - Thomas DSK
AD  - Department of Geography and Earth Sciences, University of North Carolina 
      Charlotte, NC, USA.
FAU - Peel, Jennifer L
AU  - Peel JL
AD  - Department of Environmental and Radiological Health Sciences, Colorado State 
      University, Fort Collins, CO, USA.
FAU - Adgate, John L
AU  - Adgate JL
AD  - Department of Environmental and Occupational Health, Colorado School of Public 
      Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
FAU - Magzamen, Sheryl
AU  - Magzamen S
AD  - Department of Environmental and Radiological Health Sciences, Colorado State 
      University, Fort Collins, CO, USA; Department of Epidemiology, Colorado School of 
      Public Health, Colorado State University, Fort Collins, CO, USA.
FAU - Martenies, Sheena E
AU  - Martenies SE
AD  - Department of Environmental and Radiological Health Sciences, Colorado State 
      University, Fort Collins, CO, USA.
FAU - Allshouse, William B
AU  - Allshouse WB
AD  - Department of Environmental and Occupational Health, Colorado School of Public 
      Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
FAU - Starling, Anne P
AU  - Starling AP
AD  - Department of Epidemiology, Colorado School of Public Health, University of 
      Colorado Anschutz Medical Campus, Aurora, CO, USA; Lifecourse Epidemiology of 
      Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical 
      Campus, Aurora, CO, USA.
LA  - eng
GR  - P30 CA046934/CA/NCI NIH HHS/United States
GR  - R00 ES025817/ES/NIEHS NIH HHS/United States
GR  - R01 DK076648/DK/NIDDK NIH HHS/United States
GR  - UH3 OD023248/OD/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20210420
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Air Pollutants)
RN  - 0 (Biomarkers)
RN  - 0 (Particulate Matter)
SB  - IM
MH  - *Air Pollutants/analysis/toxicity
MH  - *Air Pollution/adverse effects
MH  - Biomarkers
MH  - Female
MH  - Fetal Blood/chemistry
MH  - Humans
MH  - Infant
MH  - Maternal Exposure/adverse effects
MH  - Particulate Matter/analysis/toxicity
MH  - Pregnancy
PMC - PMC8216209
MID - NIHMS1698293
OTO - NOTNLM
OT  - Air pollution
OT  - Infant
OT  - Inflammation
OT  - Pregnancy
COIS- Declaration of interests The authors declare that they have no known competing 
      financial interests or personal relationships that could have appeared to 
      influence the work reported in this paper.
EDAT- 2021/04/16 06:00
MHDA- 2021/07/01 06:00
PMCR- 2022/06/01
CRDT- 2021/04/15 20:11
PHST- 2020/09/24 00:00 [received]
PHST- 2021/04/02 00:00 [revised]
PHST- 2021/04/09 00:00 [accepted]
PHST- 2021/04/16 06:00 [pubmed]
PHST- 2021/07/01 06:00 [medline]
PHST- 2021/04/15 20:11 [entrez]
PHST- 2022/06/01 00:00 [pmc-release]
AID - S0013-9351(21)00459-X [pii]
AID - 10.1016/j.envres.2021.111165 [doi]
PST - ppublish
SO  - Environ Res. 2021 Jun;197:111165. doi: 10.1016/j.envres.2021.111165. Epub 2021 
      Apr 20.