PMID- 33857887
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240222
IS  - 1873-376X (Electronic)
IS  - 1570-0232 (Linking)
VI  - 1173
DP  - 2021 Apr 2
TI  - UPLC-Q-TOF/MS based fecal metabolomics reveals the potential anti-diabetic effect 
      of Xiexin Decoction on T2DM rats.
PG  - 122683
LID - S1570-0232(21)00163-X [pii]
LID - 10.1016/j.jchromb.2021.122683 [doi]
AB  - Xiexin Decoction (XXD), a traditional Chinese medicine prescription composed of 
      Rhei rhizome (RR), Scutellaria radix (SR) and Coptidis rhizome (CR), has been 
      used to cure diabetes in clinical practices for thousands of years, but its 
      mechanism is not clear. Our previous study indicated that XXD could significantly 
      ameliorate the symptom of type 2 diabetes mellitus (T2DM) rats by shifting the 
      composition of gut microbiota. However, the effect of XXD on the metabolic 
      activity of gut microbiota is not clarified. In this study, the underlying 
      mechanism of XXD on the amelioration of T2DM was explored by fecal metabolic 
      profiling analysis based on ultra performance liquid chromatography coupled with 
      quadrupole time-of-fight mass spectrometry (UPLC-Q-TOF/MS). The disordered 
      metabolic profiles in T2DM rats were notably improved by XXD. Ten potential 
      biomarkers, which were mainly involved in arachidonic acid metabolism, amino acid 
      metabolism, bile acid metabolism, glycolysis and gluconeogenesis, were 
      identified. Furthermore, these metabolites were closely related to 
      SCFAs-producing and anti-inflammatory gut microflora. After XXD intervention, 
      these biomarkers restored to the normal level at some extent. This study not only 
      revealed potential biomarkers and related pathways in T2DM rats affected by XXD, 
      but also provided a novel insight to uncover how traditional herb medicines 
      worked from fecal metabolomics.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Zhang, Zhi-Miao
AU  - Zhang ZM
AD  - Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources 
      Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, 
      Nanjing 210023, PR China.
FAU - Chen, Meng-Jun
AU  - Chen MJ
AD  - Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources 
      Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, 
      Nanjing 210023, PR China.
FAU - Zou, Jun-Feng
AU  - Zou JF
AD  - Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources 
      Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, 
      Nanjing 210023, PR China.
FAU - Jiang, Shu
AU  - Jiang S
AD  - Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources 
      Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, 
      Nanjing 210023, PR China. Electronic address: jiangshu2020@126.com.
FAU - Shang, Er-Xin
AU  - Shang EX
AD  - Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources 
      Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, 
      Nanjing 210023, PR China.
FAU - Qian, Da-Wei
AU  - Qian DW
AD  - Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources 
      Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, 
      Nanjing 210023, PR China.
FAU - Duan, Jin-Ao
AU  - Duan JA
AD  - Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources 
      Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, 
      Nanjing 210023, PR China. Electronic address: dja@njutcm.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210402
PL  - Netherlands
TA  - J Chromatogr B Analyt Technol Biomed Life Sci
JT  - Journal of chromatography. B, Analytical technologies in the biomedical and life 
      sciences
JID - 101139554
SB  - IM
OTO - NOTNLM
OT  - Metabolomics
OT  - Type 2 diabetes mellitus
OT  - UPLC-Q-TOF/MS
OT  - Xiexin Decoction
EDAT- 2021/04/16 06:00
MHDA- 2021/04/16 06:01
CRDT- 2021/04/15 20:26
PHST- 2020/11/11 00:00 [received]
PHST- 2021/02/12 00:00 [revised]
PHST- 2021/03/27 00:00 [accepted]
PHST- 2021/04/16 06:01 [medline]
PHST- 2021/04/16 06:00 [pubmed]
PHST- 2021/04/15 20:26 [entrez]
AID - S1570-0232(21)00163-X [pii]
AID - 10.1016/j.jchromb.2021.122683 [doi]
PST - aheadofprint
SO  - J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Apr 2;1173:122683. doi: 
      10.1016/j.jchromb.2021.122683.