PMID- 33858060
OWN - NLM
STAT- MEDLINE
DCOM- 20210419
LR  - 20210419
IS  - 0253-9624 (Print)
IS  - 0253-9624 (Linking)
VI  - 55
IP  - 4
DP  - 2021 Apr 6
TI  - [The association between blood homocysteine level and Chinese Healthy Eating 
      Index in a suburb population of Shanghai].
PG  - 485-491
LID - 10.3760/cma.j.cn112150-20210114-00036 [doi]
AB  - Objective: To explore the relationship between the level of blood homocysteine 
      (Hcy) and the total score of Chinese Healthy Eating Index (CHEI) and its item 
      score. Methods: The subjects were recruited from the East China Natural 
      Population Cohort Study, led by the School of Public Health in Fudan University, 
      which was conducted in Zhongshan Community, Songjiang District of Shanghai from 
      April to September 2017. By using the cluster random sampling method, 8 
      neighborhood committees were randomly selected from 18 neighborhood committees in 
      Zhongshan community (Beimen, Baiyun, Dongwai, Huaqiao, Lantian village 1, Lantian 
      village 2, Lantian village 4, and Lantian village 5). All the residents who met 
      the standard and had lived in Shanghai for more than half a year were selected as 
      research subjects. 4 995 subjects with complete survey information were finally 
      included in this study. General information (age, sex, disease history, etc.), 
      lifestyle (smoking, drinking, tea drinking, physical activity, etc.), food 
      frequency and blood Hcy concentration were collected through questionnaire 
      survey, physical examination and biological sample detection. The multivariate 
      linear regression model was used to analyze the correlation between blood Hcy 
      concentration and the total score of CHEI and its item score, and the 
      multivariate logistics regression model was used to analyze the correlation 
      between hyperhomocysteinemia (hHcy) and the total score of CHEI and its item 
      score. Results: The age of the subjects was (56.72+/-9.72) years. The proportion of 
      females, people with middle and high school education and high physical activity 
      was 64.90% (3 241), 50.80% (2 539) and 63.20% (3 157), respectively. The blood 
      Hcy concentration was (11.25+/-4.90) mumol/L, and the total prevalence of hHcy was 
      9.3% (467 cases). The results of multivariate linear regression showed that after 
      adjusting for the relevant confounding factors, the blood Hcy concentration of 
      subjects decreased with the increase of the total score of CHEI and the item 
      score of fruit, milk, seafood, poultry and egg, but increased with the increase 
      of the item score of total grain and tuber. In males, blood Hcy levels decreased 
      with the increase of the item score of seafood and poultry [beta (95%CI) values were 
      -0.343 (-0.582, -0.102) and -0.225 (-0.402, -0.046), respectively]. In females, 
      the blood Hcy level decreased with the increase of the total score of CHEI and 
      its item score of milk, egg, seafood and poultry [beta (95%CI) values were -0.130 
      (-0.207, -0.052), -0.091 (-0.148, -0.034), -0.016 (-0.026, -0.007), -0.069 
      (-0.122, -0.016), and -0.087 (-0.157, -0.017), respectively]. The results of 
      multivariate logistic regression showed that the higher the total score of CHEI 
      and its item score of milk and seafood, the lower the risk of hHcy [OR (95%CI) 
      value were 0.986 (0.978, 0.995), 0.915 (0.864, 0.969), and 0.862 (0.806, 0.922), 
      respectively]. In females, the higher the total score of CHEI and its item score 
      of milk and seafood, the lower the risk of hHcy [OR (95%CI) values were 0.984 
      (0.970, 0.999), 0.877 (0.802, 0.958), and 0.845 (0.760, 0.941), respectively]. In 
      males, the higher the total score of CHEI and its item score of seafood, the 
      lower the risk of hHcy [OR (95%CI) values were 0.988 (0.977, 0.998) and 0.858 
      (0.791, 0.930), respectively]. Conclusion: The dietary pattern of residents in 
      Zhongshan Community, Songjiang District, Shanghai can affect their own blood Hcy 
      concentration and the risk of hHcy. The total score of CHEI and the item score of 
      fruit, milk, seafood, poultry and eggs play an important role in reducing the 
      level of blood Hcy. The higher the total score of CHEI and the item score of milk 
      and seafood, the lower the risk of hHcy.
FAU - Liu, S J
AU  - Liu SJ
AD  - School of Public Health, Fudan University, Shanghai 200032, China.
FAU - Yu, J G
AU  - Yu JG
AD  - Zhongshan Community Health Care Center, Songjiang District, Shanghai 201613, 
      China.
FAU - Li, J
AU  - Li J
AD  - Zhongshan Community Health Care Center, Songjiang District, Shanghai 201613, 
      China.
FAU - Li, S G
AU  - Li SG
AD  - School of Public Health, Fudan University, Shanghai 200032, China.
FAU - Chen, B
AU  - Chen B
AD  - School of Public Health, Fudan University, Shanghai 200032, China.
FAU - Zhao, G M
AU  - Zhao GM
AD  - School of Public Health, Fudan University, Shanghai 200032, China.
LA  - chi
GR  - 2017YFC0907001/National Key Research and Development Program of China/
PT  - Journal Article
PL  - China
TA  - Zhonghua Yu Fang Yi Xue Za Zhi
JT  - Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
JID - 7904962
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Aged
MH  - China/epidemiology
MH  - Cohort Studies
MH  - *Diet, Healthy
MH  - Female
MH  - Homocysteine
MH  - Humans
MH  - *Hyperhomocysteinemia
MH  - Male
MH  - Middle Aged
EDAT- 2021/04/16 06:00
MHDA- 2021/04/20 06:00
CRDT- 2021/04/15 23:25
PHST- 2021/04/15 23:25 [entrez]
PHST- 2021/04/16 06:00 [pubmed]
PHST- 2021/04/20 06:00 [medline]
AID - 10.3760/cma.j.cn112150-20210114-00036 [doi]
PST - ppublish
SO  - Zhonghua Yu Fang Yi Xue Za Zhi. 2021 Apr 6;55(4):485-491. doi: 
      10.3760/cma.j.cn112150-20210114-00036.