PMID- 33860447
OWN - NLM
STAT- MEDLINE
DCOM- 20220407
LR  - 20220407
IS  - 2190-3948 (Electronic)
IS  - 2190-393X (Print)
IS  - 2190-393X (Linking)
VI  - 11
IP  - 4
DP  - 2021 Aug
TI  - Inflammation-responsive delivery systems for the treatment of chronic 
      inflammatory diseases.
PG  - 1475-1497
LID - 10.1007/s13346-021-00977-8 [doi]
AB  - Inflammation is the biological response of immune system to protect living 
      organisms from injurious factors. However, excessive and uncontrolled 
      inflammation is implicated in a variety of devastating chronic diseases including 
      atherosclerosis, inflammatory bowel disease (IBD), and rheumatoid arthritis (RA). 
      Improved understanding of inflammatory response has unveiled a rich assortment of 
      anti-inflammatory therapeutics for the treatment and management of relevant 
      chronic diseases. Notwithstanding these successes, clinical outcomes are variable 
      among patients and serious adverse effects are often observed. Moreover, there 
      exist some limitations for clinical anti-inflammatory therapeutics such as 
      aqueous insolubility, low bioavailability, off-target effects, and poor 
      accessibility to subcellular compartments. To address these challenges, the 
      rational design of inflammation-specific drug delivery systems (DDSs) holds 
      significant promise. Moreover, as compared to normal tissues, inflamed 
      tissue-associated pathological milieu (e.g., oxidative stress, acidic pH, and 
      overexpressed enzymes) provides vital biochemical stimuli for triggered delivery 
      of anti-inflammatory agents in a spatiotemporally controlled manner. In this 
      review, we summarize recent advances in the development of anti-inflammatory DDSs 
      with built-in pathological inflammation-specific responsiveness for the treatment 
      of chronic inflammatory diseases.
FAU - Deng, Zhengyu
AU  - Deng Z
AUID- ORCID: 0000-0002-7186-7491
AD  - CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for 
      Physical Sciences At the Microscale, Department of Polymer Science and 
      Engineering, University of Science and Technology of China, 96 Jinzhai Road, 
      Hefei, 230026, Anhui Province, China.
FAU - Liu, Shiyong
AU  - Liu S
AUID- ORCID: 0000-0002-9789-6282
AD  - CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for 
      Physical Sciences At the Microscale, Department of Polymer Science and 
      Engineering, University of Science and Technology of China, 96 Jinzhai Road, 
      Hefei, 230026, Anhui Province, China. sliu@ustc.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210415
PL  - United States
TA  - Drug Deliv Transl Res
JT  - Drug delivery and translational research
JID - 101540061
RN  - 0 (Anti-Inflammatory Agents)
SB  - IM
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Chronic Disease
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Inflammation/drug therapy
MH  - *Inflammatory Bowel Diseases/drug therapy
PMC - PMC8048351
OTO - NOTNLM
OT  - Anti-inflammatory agents
OT  - Drug delivery systems (DDSs)
OT  - Inflammation
OT  - Inflammatory microenvironment
OT  - Oxidative stress
OT  - Stimuli-responsive polymers
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/04/17 06:00
MHDA- 2022/04/08 06:00
PMCR- 2021/04/15
CRDT- 2021/04/16 06:48
PHST- 2021/04/03 00:00 [accepted]
PHST- 2021/04/17 06:00 [pubmed]
PHST- 2022/04/08 06:00 [medline]
PHST- 2021/04/16 06:48 [entrez]
PHST- 2021/04/15 00:00 [pmc-release]
AID - 10.1007/s13346-021-00977-8 [pii]
AID - 977 [pii]
AID - 10.1007/s13346-021-00977-8 [doi]
PST - ppublish
SO  - Drug Deliv Transl Res. 2021 Aug;11(4):1475-1497. doi: 10.1007/s13346-021-00977-8. 
      Epub 2021 Apr 15.