PMID- 33861724
OWN - NLM
STAT- MEDLINE
DCOM- 20211115
LR  - 20220531
IS  - 0236-6290 (Print)
IS  - 0236-6290 (Linking)
VI  - 69
IP  - 1
DP  - 2021 Apr 15
TI  - Phylogenetic and topological analyses of the bovine interferon-induced 
      transmembrane protein (IFITM3).
PG  - 14-22
LID - 10.1556/004.2021.00010 [doi]
AB  - Interferon-induced transmembrane protein 3 (IFITM3) plays a pivotal role in 
      antiviral capacity in several species. However, to date, investigations of the 
      IFITM3 protein in cattle have been rare. According to recent studies, 
      interspecific differences in the IFITM3 protein result in several unique features 
      of the IFITM3 protein relative to primates and birds. Thus, in the present study, 
      we investigated the bovine IFITM3 protein based on nucleotide and amino acid 
      sequences to find its distinct features. We found that the bovine IFITM3 gene 
      showed a significantly different length and homology relative to other species, 
      including primates, rodents and birds. Phylogenetic analyses indicated that the 
      bovine IFITM3 gene and IFITM3 protein showed closer evolutionary distance with 
      primates than with rodents. However, cattle showed an independent clade among 
      primates, rodents and birds. Multiple sequence alignment of the IFITM3 protein 
      indicated that the bovine IFITM3 protein contains 36 bovine-specific amino acids. 
      Notably, the bovine IFITM3 protein was predicted to prefer inside-to-outside 
      topology of intramembrane domain 1 (IMD1) and inside-to-outside topology of 
      transmembrane domain 2 by TMpred and three membrane embedding domains according 
      to the SOSUI system.
FAU - Kim, Yong-Chan
AU  - Kim YC
AD  - 1Korea Zoonosis Research Institute, Jeonbuk National University, 820-120 Hana-ro, 
      Iksan, Jeonbuk 54531, Republic of Korea.
AD  - 2Department of Bioactive Material Sciences and Institute for Molecular Biology 
      and Genetics, Jeonbuk National University, Jeonju, Jeonbuk 54531, Republic of 
      Korea.
FAU - Jeong, Byung-Hoon
AU  - Jeong BH
AUID- ORCID: 0000-0002-4525-9994
AD  - 1Korea Zoonosis Research Institute, Jeonbuk National University, 820-120 Hana-ro, 
      Iksan, Jeonbuk 54531, Republic of Korea.
AD  - 2Department of Bioactive Material Sciences and Institute for Molecular Biology 
      and Genetics, Jeonbuk National University, Jeonju, Jeonbuk 54531, Republic of 
      Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210415
PL  - Hungary
TA  - Acta Vet Hung
JT  - Acta veterinaria Hungarica
JID - 8406376
RN  - 0 (Antiviral Agents)
RN  - 0 (Membrane Proteins)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antiviral Agents
MH  - Cattle
MH  - *Interferons
MH  - *Membrane Proteins/genetics
MH  - Phylogeny
OTO - NOTNLM
OT  - IFITM3
OT  - cattle
OT  - interferon-stimulated gene
OT  - topology
EDAT- 2021/04/17 06:00
MHDA- 2021/11/16 06:00
CRDT- 2021/04/16 17:15
PHST- 2020/11/30 00:00 [received]
PHST- 2021/03/08 00:00 [accepted]
PHST- 2021/04/17 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2021/04/16 17:15 [entrez]
AID - 10.1556/004.2021.00010 [doi]
PST - epublish
SO  - Acta Vet Hung. 2021 Apr 15;69(1):14-22. doi: 10.1556/004.2021.00010.