PMID- 33861987
OWN - NLM
STAT- MEDLINE
DCOM- 20210806
LR  - 20210806
IS  - 1873-2933 (Electronic)
IS  - 0009-9120 (Linking)
VI  - 93
DP  - 2021 Jul
TI  - Polymorphisms of interleukin 4 and interleukin 4 receptor genes and bronchial 
      asthma risk among Egyptian children.
PG  - 66-72
LID - S0009-9120(21)00109-0 [pii]
LID - 10.1016/j.clinbiochem.2021.04.006 [doi]
AB  - BACKGROUND: Interleukin 4 (IL4) is a key cytokine that regulates the inflammatory 
      cascade in bronchial asthma. We investigated the association between the IL4 and 
      IL4R polymorphisms and the susceptibility for bronchial asthma among Egyptian 
      children. METHODS: IL4 VNTR and IL4R c.1902 A>G p.(Q576R) polymorphisms were 
      investigated among 100 children with bronchial asthma and 100 healthy controls 
      using PCR method. Serum levels of IL4 and immunoglobulin E (IgE) were assessed by 
      ELISA. RESULTS: The frequencies of (A1A2 + A2A2) genotypes and A2-allele of the 
      IL4 VNTR variant were significantly higher among asthmatic patients than controls 
      (p = 0.01, OR = 2.34, 95% CI = 1.24-4.44; p = 0.01, OR = 2.27, 95% 
      CI = 1.29-3.99, respectively). The frequencies of (AG + GG) genotypes and 
      G-allele of the IL4R (A1902G) variant were significantly higher among asthmatic 
      patients than controls (p = 0.003, OR = 2.52, 95% CI = 1.39-4.58; p = 0.002, 
      OR = 2.25, 95% CI = 1.35-3.76, respectively). There was a significant association 
      between (A1A2 + A2A2) genotypes of the IL4 VNTR variant and high serum IL4 level 
      among asthmatic patients (p < 0.001). The (AG + GG) genotypes of the IL4R 
      (A1902G) variant were significantly associated with exposure to triggers, atopic 
      dermatitis and higher serum IgE level in asthmatic patients (p = 0.02, 0.04 and 
      0.01, respectively). CONCLUSION: IL4 VNTR and IL4R (A1902G) polymorphisms could 
      be associated with higher risks of bronchial asthma among Egyptian children.
CI  - Copyright (c) 2021 The Canadian Society of Clinical Chemists. Published by Elsevier 
      Inc. All rights reserved.
FAU - Elsaid, Afaf
AU  - Elsaid A
AD  - Biochemistry Section, Mansoura University Children's Hospital, Mansoura, Egypt.
FAU - Shoaib, Rasha M S
AU  - Shoaib RMS
AD  - Biochemistry Department, Faculty of Science, Damietta University, Damietta, 
      Egypt. Electronic address: rashashoaib83@yahoo.com.
FAU - Badr, Sara S
AU  - Badr SS
AD  - Biochemistry Department, Faculty of Science, Damietta University, Damietta, 
      Egypt.
FAU - Wahba, Yahya
AU  - Wahba Y
AD  - Pediatric Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
FAU - Ayyad, Seif-Eldin N
AU  - Ayyad SN
AD  - Chemistry Department, Faculty of Science, Damietta University, Damietta, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20210420
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (IL4 protein, human)
RN  - 0 (IL4R protein, human)
RN  - 0 (Interleukin-4 Receptor alpha Subunit)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Alleles
MH  - Asthma/blood/complications/*genetics/immunology
MH  - Case-Control Studies
MH  - Child
MH  - Dermatitis, Atopic/blood/etiology/genetics/immunology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Healthy Volunteers
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Interleukin-4/blood/*genetics
MH  - Interleukin-4 Receptor alpha Subunit/*genetics
MH  - Male
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Principal Component Analysis
OTO - NOTNLM
OT  - Bronchial asthma
OT  - Interleukin 4
OT  - Interleukin 4 receptor
EDAT- 2021/04/17 06:00
MHDA- 2021/08/07 06:00
CRDT- 2021/04/16 20:10
PHST- 2021/02/09 00:00 [received]
PHST- 2021/04/01 00:00 [revised]
PHST- 2021/04/09 00:00 [accepted]
PHST- 2021/04/17 06:00 [pubmed]
PHST- 2021/08/07 06:00 [medline]
PHST- 2021/04/16 20:10 [entrez]
AID - S0009-9120(21)00109-0 [pii]
AID - 10.1016/j.clinbiochem.2021.04.006 [doi]
PST - ppublish
SO  - Clin Biochem. 2021 Jul;93:66-72. doi: 10.1016/j.clinbiochem.2021.04.006. Epub 
      2021 Apr 20.