PMID- 33862112
OWN - NLM
STAT- MEDLINE
DCOM- 20210706
LR  - 20230410
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 278
DP  - 2021 Aug 1
TI  - Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-3p targets SOCS1 
      to facilitate progression of esophageal cancer.
PG  - 119491
LID - S0024-3205(21)00476-8 [pii]
LID - 10.1016/j.lfs.2021.119491 [doi]
AB  - OBJECTIVE: Exosomes can convey particular microRNAs (miRNAs) to affect biological 
      functions of cancer cells. Nevertheless, the impact of bone marrow mesenchymal 
      stem cells (BMSCs)-derived exosomes (BMSC-exos) transmitting miR-19b-3p on 
      esophageal cancer (EC) progression remains scarcely studied. We aimed to explore 
      the role of BMSC-exos mediating miR-19b-3p in EC cell growth. METHODS: 
      Eighty-three cases of EC patients were included in this study and the expression 
      of miR-19b-3p and suppressor of cytokine signaling 1 (SOCS1) in cancer and 
      adjacent normal tissues from the patients were assessed. BMSCs were cultured and 
      BMSC-exos were extracted, which were then transfected with altered miR-19b-3p and 
      SOCS1 to assess their roles in proliferation, migration, invasion, 
      epithelial-mesenchymal transition (EMT) and apoptosis of EC cells. Targeting 
      relationship between miR-19b-3p and SOCS1 was verified by Targetscan and dual 
      luciferase reporter gene assay. MiR-19b-3p and SOCS1 expression was assessed in 
      TE-2 cells. RESULTS: MiR-19b-3p was upregulated and SOCS1 was downregulated in EC 
      tissues. BMSC-exos or exosomal miR-19b-3p promoted malignant behaviors of EC 
      cells. MiR-19b-3p was upregulated and targeted SOCS1 in EC cells. MiR-19b-3p 
      inhibition or SOCS1 overexpression suppressed proliferation, migration, invasion 
      and EMT, and induced apoptosis of EC cells. SOCS1 silencing abrogated these 
      effect of miR-19b-3p inhibition on EC cells. CONCLUSION: BMSC-derived exosomal 
      miR-19b-3p promotes progression of EC through targeting SOCS1. This study 
      provides a novel understanding on molecular mechanisms of EC.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Deng, Yanchao
AU  - Deng Y
AD  - Department of Thoracic Surgery, The First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, 830054, Xinjiang, China. Electronic address: 
      Dengyanchao123@outlook.com.
FAU - Julaiti, Ainiwaer
AU  - Julaiti A
AD  - Department of Thoracic Surgery, The First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, 830054, Xinjiang, China.
FAU - Ran, Wei
AU  - Ran W
AD  - The First Clinical Medicine College of Xinjiang Medical University, Urumqi, 
      830054, Xinjiang, China.
FAU - He, Yao
AU  - He Y
AD  - The First Clinical Medicine College of Xinjiang Medical University, Urumqi, 
      830054, Xinjiang, China.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20210413
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (MIRN19 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (SOCS1 protein, human)
RN  - 0 (Suppressor of Cytokine Signaling 1 Protein)
SB  - IM
RIN - Life Sci. 2023 May 15;321:121602. PMID: 36990908
MH  - Apoptosis
MH  - Bone Marrow Cells/*metabolism
MH  - Cell Line
MH  - Cell Movement
MH  - Cell Proliferation
MH  - Disease Progression
MH  - Epithelial-Mesenchymal Transition
MH  - Esophageal Neoplasms/*metabolism
MH  - Exosomes/metabolism
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Mesenchymal Stem Cells/*metabolism
MH  - MicroRNAs/*metabolism
MH  - Neoplasm Invasiveness
MH  - Suppressor of Cytokine Signaling 1 Protein/*metabolism
OTO - NOTNLM
OT  - Apoptosis
OT  - Bone marrow mesenchymal stem cells-derived exosome
OT  - Esophageal cancer
OT  - MicroRNA-19b-3p
OT  - Proliferation
OT  - Suppressor of cytokine signaling 1
EDAT- 2021/04/17 06:00
MHDA- 2021/07/07 06:00
CRDT- 2021/04/16 20:12
PHST- 2020/09/22 00:00 [received]
PHST- 2021/04/06 00:00 [revised]
PHST- 2021/04/09 00:00 [accepted]
PHST- 2021/04/17 06:00 [pubmed]
PHST- 2021/07/07 06:00 [medline]
PHST- 2021/04/16 20:12 [entrez]
AID - S0024-3205(21)00476-8 [pii]
AID - 10.1016/j.lfs.2021.119491 [doi]
PST - ppublish
SO  - Life Sci. 2021 Aug 1;278:119491. doi: 10.1016/j.lfs.2021.119491. Epub 2021 Apr 
      13.