PMID- 33862176
OWN - NLM
STAT- MEDLINE
DCOM- 20211215
LR  - 20211215
IS  - 1872-9754 (Electronic)
IS  - 0197-0186 (Linking)
VI  - 146
DP  - 2021 Jun
TI  - Ketamine for post-traumatic stress disorders and it's possible therapeutic 
      mechanism.
PG  - 105044
LID - S0197-0186(21)00090-5 [pii]
LID - 10.1016/j.neuint.2021.105044 [doi]
AB  - Posttraumatic stress disorder (PTSD) is a devastating medical illness, for which 
      currently available pharmacotherapies have poor efficacy. Accumulating evidence 
      from clinical and preclinical animal investigations supports that ketamine 
      exhibits a rapid and persistent effect against PTSD, though the underlying 
      molecular mechanism remains to be clarified. In this literature review, we 
      recapitulate the achievements from early ketamine studies to the most up-to-date 
      discoveries, with an effort to discuss an inclusive therapeutic role of ketamine 
      for PTSD treatment and its possible therapeutic mechanism. Ketamine seems to have 
      an inimitable mechanism of action entailing glutamate modulation via actions at 
      the N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole 
      propionic acid (AMPA) receptors, as well as downstream activation of 
      brain-derived neurotrophic factor (BDNF) and mechanistic target of rapamycin 
      (mTOR) signaling pathways to potentiate synaptic plasticity.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Asim, Muhammad
AU  - Asim M
AD  - Key Laboratory of Neuroscience, Department of Biomedical Science, City University 
      of Hong Kong, Kowloon Tong, Hong Kong; Faculty of Forensic Medicine, Zhongshan 
      School of Medicine, Sun Yat-Sen University, Guangzhou, China; Guangdong Province 
      Translational Forensic Medicine Engineering Technology Research Center, Zhongshan 
      School of Medicine, Sun Yat-Sen University, Guangzhou, China.
FAU - Wang, Bing
AU  - Wang B
AD  - Department of Neurosurgery, The Second Affiliated Hospital, University of South 
      China, Hengyang, China.
FAU - Hao, Bo
AU  - Hao B
AD  - Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-Sen 
      University, Guangzhou, China; Guangdong Province Translational Forensic Medicine 
      Engineering Technology Research Center, Zhongshan School of Medicine, Sun Yat-Sen 
      University, Guangzhou, China; Guangdong Province Key Laboratory of Brain Function 
      and Disease, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 
      China.
FAU - Wang, Xiaoguang
AU  - Wang X
AD  - Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-Sen 
      University, Guangzhou, China; Guangdong Province Translational Forensic Medicine 
      Engineering Technology Research Center, Zhongshan School of Medicine, Sun Yat-Sen 
      University, Guangzhou, China; Guangdong Province Key Laboratory of Brain Function 
      and Disease, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 
      China. Electronic address: wxguang@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210413
PL  - England
TA  - Neurochem Int
JT  - Neurochemistry international
JID - 8006959
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 690G0D6V8H (Ketamine)
SB  - IM
MH  - Animals
MH  - Excitatory Amino Acid Antagonists/pharmacology/*therapeutic use
MH  - Humans
MH  - Ketamine/pharmacology/*therapeutic use
MH  - Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors/metabolism
MH  - Stress Disorders, Post-Traumatic/*drug therapy/metabolism
OTO - NOTNLM
OT  - CCK
OT  - Ketamine
OT  - NMDAR
OT  - PTSD
EDAT- 2021/04/17 06:00
MHDA- 2021/12/16 06:00
CRDT- 2021/04/16 20:13
PHST- 2020/12/19 00:00 [received]
PHST- 2021/04/02 00:00 [revised]
PHST- 2021/04/07 00:00 [accepted]
PHST- 2021/04/17 06:00 [pubmed]
PHST- 2021/12/16 06:00 [medline]
PHST- 2021/04/16 20:13 [entrez]
AID - S0197-0186(21)00090-5 [pii]
AID - 10.1016/j.neuint.2021.105044 [doi]
PST - ppublish
SO  - Neurochem Int. 2021 Jun;146:105044. doi: 10.1016/j.neuint.2021.105044. Epub 2021 
      Apr 13.