PMID- 33864173
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210507
IS  - 2197-1153 (Print)
IS  - 2197-1153 (Electronic)
IS  - 2197-1153 (Linking)
VI  - 8
IP  - 1
DP  - 2021 Apr 17
TI  - Early outcomes and predictors of patient satisfaction after TKA: a prospective 
      study of 200 cases with a contemporary cemented rotating platform implant design.
PG  - 30
LID - 10.1186/s40634-021-00347-w [doi]
LID - 30
AB  - PURPOSE: The purpose of the study was to identify the earliest time point where 
      subjects realized the greatest clinical improvement after TKA, and the time when 
      post-operative scores became superior to pre-operative scores. Post-hoc 
      exploratory analyses were conducted to investigate predictors of early 
      post-operative outcomes and patient satisfaction. METHODS: Six investigators 
      across 4 sites in the Netherlands prospectively implanted 200 subjects with a 
      contemporary cemented rotating platform device. Patient Reported Outcome 
      Measurements (PROMs) KOOS-PS, PKIP, and EQ-5D were collected pre-operatively and 
      post-operatively through 2-years. PROMs change from pre-operative baseline were 
      summarized, along with radiographic outcomes and adverse events (AEs). 
      Pre-operative patient characteristics were explored for correlation with patient 
      outcomes, and patient satisfaction for correlation with KOOS-PS. RESULTS: 
      Follow-up compliance was 99% at 6-months, and 95.5% at 2-years. The percentage 
      with higher KOOS-PS compared to baseline was 81.3% at 6-months. KOOS-PS, PKIP, 
      and PKIP subscore means were all better at 6-weeks versus baseline. Gender, BMI, 
      hypertension, and pre-operative KOOS-PS were weakly correlated with 6-week 
      KOOS-PS (multivariate R-squared = 14.1%), but only pre-operative KOOS-PS 
      demonstrated correlation with post-operative KOOS-PS at 6-months or later 
      (R-squared < 5% at 6-months and 2 years). Satisfaction was moderately correlated 
      with concurrent KOOS-PS at each post-operative time point, with 
      (R-squared = 35.3% at 6-months, and 37.5% at 2 years). CONCLUSION: The greatest 
      mean clinical improvement occurred within the first 6-weeks. Although some 
      pre-operative factors were correlated with higher early post-operative KOOS-PS 
      outcomes, these advantages disappeared by 6-months aside from weak correlation 
      with pre-operative KOOS-PS. Post-operative KOOS-PS was moderately correlated with 
      concurrent post-operative satisfaction. These results may be used for 
      pre-operative counseling and management of patient's postoperative expectations. 
      TRIAL REGISTRATION: Clinicaltrials.gov, NCT02339610 . Registered 15 January 2015.
FAU - van Loon, Corne
AU  - van Loon C
AD  - Orthopaedic Department, Rijnstate Hospital, PO Box 9555, 6800 TA, Arnhem, The 
      Netherlands.
FAU - Baas, Niels
AU  - Baas N
AD  - HAGA Hospital, Sportlaan 600, 2566 MJ, The Hague, The Netherlands.
AD  - Present Address: Bergman Clinics, Laan van Oversteen 20, 2289 CS, Rijswijk, The 
      Hague, The Netherlands.
FAU - Huey, Verdonna
AU  - Huey V
AD  - DePuy Synthes Joint Reconstruction, Inc., PO Box 988, 700 Orthopaedic Drive, 
      Warsaw, IN, 46581-0988, USA.
FAU - Lesko, James
AU  - Lesko J
AUID- ORCID: 0000-0003-1178-2741
AD  - DePuy Synthes Joint Reconstruction, Inc., PO Box 988, 700 Orthopaedic Drive, 
      Warsaw, IN, 46581-0988, USA. jlesko12@its.jnj.com.
FAU - Meermans, Geert
AU  - Meermans G
AD  - Orthopaedic Department, Bravis Hospital, Boerhaaveplein 1, 4624 VT, Bergen Op 
      Zoom, The Netherlands.
FAU - Vergroesen, Diederik
AU  - Vergroesen D
AD  - Spaarne Hospital, Spaarne Poort 1, 2134 TM, Hoofddorp, The Netherlands.
LA  - eng
SI  - ClinicalTrials.gov/NCT02339610
PT  - Journal Article
DEP - 20210417
PL  - United States
TA  - J Exp Orthop
JT  - Journal of experimental orthopaedics
JID - 101653750
PMC - PMC8052397
COIS- Four authors received research support from DePuy Synthes as clinical study 
      investigators in this study, two authors are DePuy Synthes employees, and one or 
      more authors own Johnson & Johnson stock or stock options.
EDAT- 2021/04/18 06:00
MHDA- 2021/04/18 06:01
PMCR- 2021/04/17
CRDT- 2021/04/17 06:07
PHST- 2021/02/25 00:00 [received]
PHST- 2021/03/25 00:00 [accepted]
PHST- 2021/04/17 06:07 [entrez]
PHST- 2021/04/18 06:00 [pubmed]
PHST- 2021/04/18 06:01 [medline]
PHST- 2021/04/17 00:00 [pmc-release]
AID - 10.1186/s40634-021-00347-w [pii]
AID - 347 [pii]
AID - 10.1186/s40634-021-00347-w [doi]
PST - epublish
SO  - J Exp Orthop. 2021 Apr 17;8(1):30. doi: 10.1186/s40634-021-00347-w.