PMID- 33864656
OWN - NLM
STAT- Publisher
LR  - 20240222
IS  - 1440-1819 (Electronic)
IS  - 1323-1316 (Linking)
DP  - 2021 Apr 17
TI  - Impaired error-related processing in patients with first-episode psychosis and 
      subjects at clinical high risk for psychosis: An event-related potential study.
LID - 10.1111/pcn.13219 [doi]
AB  - AIM: Impaired event-related potential (ERP) indices reflecting 
      performance-monitoring systems have been consistently reported in patients with 
      schizophrenia. However, whether these impairments exist from the beginning of the 
      early phase of psychosis, such as in first-episode psychosis (FEP) patients and 
      individuals at clinical high risk (CHR) for psychosis, has not yet been clearly 
      ascertained. METHODS: Thirty-seven FEP patients, 22 CHR subjects, and 22 healthy 
      controls (HC) performed a visual go/no-go task so that three ERP components 
      associated with performance monitoring-error-related negativity (ERN), correct 
      response negativity (CRN), and error positivity (Pe) -could be assessed. 
      Repeated-measures analysis of variance (ANOVA) with age and sex as covariates was 
      used to compare ERN, CRN, and Pe across the groups. RESULTS: Repeated-measures 
      ANOVA with age and sex as covariates revealed that compared with HC, FEP patients 
      and CHR subjects showed significantly smaller ERN amplitudes at the Fz 
      (F = 4.980, P = 0.009) and FCz (F = 3.453, P = 0.037) electrode sites. Neither 
      CRN nor Pe amplitudes showed significant differences across the FEP, CHR, and HC 
      groups. CONCLUSION: These findings suggest that performance monitoring is already 
      compromised during the early course of psychotic disorders, evident in FEP 
      patients and CHR subjects, as reflected in the reduced ERN amplitude. Considering 
      these findings, ERN could serve as a potential indicator of early-stage 
      psychosis.
CI  - (c) 2021 The Authors Psychiatry and Clinical Neurosciences (c) 2021 Japanese Society 
      of Psychiatry and Neurology.
FAU - Park, Jihye
AU  - Park J
AD  - Department of Brain and Cognitive Sciences, Seoul National University College of 
      Natural Sciences, Seoul, Republic of Korea.
FAU - Lho, Silvia Kyungjin
AU  - Lho SK
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Hwang, Wu Jeong
AU  - Hwang WJ
AD  - Department of Brain and Cognitive Sciences, Seoul National University College of 
      Natural Sciences, Seoul, Republic of Korea.
FAU - Moon, Sun-Young
AU  - Moon SY
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Oh, Sanghoon
AU  - Oh S
AD  - Department of Psychiatry, Eulji University Uijeongbu Eulji Medical Center, 
      Gyeonggi, Republic of Korea.
FAU - Kim, Minah
AU  - Kim M
AUID- ORCID: 0000-0001-8668-0817
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Kwon, Jun Soo
AU  - Kwon JS
AD  - Department of Brain and Cognitive Sciences, Seoul National University College of 
      Natural Sciences, Seoul, Republic of Korea.
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
AD  - Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea.
LA  - eng
GR  - 2019R1C1C1002457/National Research Foundation of Korea/
GR  - 2020M3E5D9079910/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20210417
PL  - Australia
TA  - Psychiatry Clin Neurosci
JT  - Psychiatry and clinical neurosciences
JID - 9513551
SB  - IM
OTO - NOTNLM
OT  - clinical high risk
OT  - early psychosis
OT  - error-related negativity
OT  - first-episode psychosis
OT  - performance monitoring
EDAT- 2021/04/18 06:00
MHDA- 2021/04/18 06:00
CRDT- 2021/04/17 12:12
PHST- 2021/03/05 00:00 [revised]
PHST- 2020/11/05 00:00 [received]
PHST- 2021/04/11 00:00 [accepted]
PHST- 2021/04/18 06:00 [pubmed]
PHST- 2021/04/18 06:00 [medline]
PHST- 2021/04/17 12:12 [entrez]
AID - 10.1111/pcn.13219 [doi]
PST - aheadofprint
SO  - Psychiatry Clin Neurosci. 2021 Apr 17. doi: 10.1111/pcn.13219.