PMID- 33864707
OWN - NLM
STAT- MEDLINE
DCOM- 20211203
LR  - 20211214
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 11
IP  - 10
DP  - 2021 Oct
TI  - Disease involvement in the central compartment in eosinophilic chronic 
      rhinosinusitis.
PG  - 1417-1423
LID - 10.1002/alr.22803 [doi]
AB  - OBJECTIVE: To evaluate disease presence in the central compartment (CC) in 
      patients with eosinophilic chronic rhinosinusitis (CRS). METHODS: Patients with 
      eosinophilic CRS were divided into three endotypes: aspirin-exacerbated 
      respiratory disease (AERD), allergic fungal rhinosinusitis (AFRS), and 
      eosinophilic CRS with nasal polyps (eCRSwNP). CT scans were reviewed for CC 
      involvement, defined as the area between the superior nasal septum (SNS) and 
      middle turbinate (MT). CC involvement was measured based on the degree of 
      opacification (0: no opacification, 1: up to 50% opacification, and 2: >50% 
      opacification), and distance from SNS to MT (mm). Patients who had lateralized 
      MTs from prior surgery as the cause of CC widening were excluded. Patients who 
      underwent orbital decompression were included as a control group. RESULTS: Fifty 
      patients in each group (AERD, AFRS, and eCRSwNP) and 50 control patients were 
      included. Average number of surgeries was 2.5 in AERD (p = 0.05), 2 in AFRS 
      (p = 0.4), and 1.7 in eCRSwNP. Preoperative CC distance was significantly higher 
      in AERD versus control, AFRS, and eCRSwNP: 4.2 versus 2.8 mm (p < 0.0001), 4.2 
      versus 1.9 mm (p < 0.0001), and 4.2 versus 2.7 mm (p < 0.0001), respectively. 
      Postoperatively, CC distance and degree of opacification were significantly 
      higher in AERD versus control, AFRS, and eCRSwNP. Within the AERD group, CC 
      distance was significantly higher postoperatively than preoperatively (6.5 vs. 
      4.2 mm, p = 0.002). CONCLUSION: CC involvement is more significant in AERD 
      patients and if present, rhinologists should be suspicious of the diagnosis. This 
      area could represent a source of inflammatory load in patients with AERD.
CI  - (c) 2021 ARS-AAOA, LLC.
FAU - Makary, Chadi A
AU  - Makary CA
AD  - Department of Otolaryngology-Head and Neck Surgery, West Virginia University, 
      Morgantown, West Virginia, USA.
FAU - Falco, Jeffrey
AU  - Falco J
AD  - Department of Otolaryngology-Head and Neck Surgery, Medical College of 
      Georgia-Augusta University, Augusta, Georgia, USA.
FAU - Sussman, Sarah
AU  - Sussman S
AD  - Department of Otolaryngology-Head and Neck Surgery, West Virginia University, 
      Morgantown, West Virginia, USA.
FAU - Ryan, Lindsey
AU  - Ryan L
AD  - Department of Otolaryngology-Head and Neck Surgery, Medical College of 
      Georgia-Augusta University, Augusta, Georgia, USA.
FAU - Reyes, Camilo
AU  - Reyes C
AD  - Department of Otolaryngology-Head and Neck Surgery, Medical College of 
      Georgia-Augusta University, Augusta, Georgia, USA.
FAU - Ramadan, Hassan
AU  - Ramadan H
AD  - Department of Otolaryngology-Head and Neck Surgery, West Virginia University, 
      Morgantown, West Virginia, USA.
FAU - Kountakis, Stilianos E
AU  - Kountakis SE
AD  - Department of Otolaryngology-Head and Neck Surgery, Medical College of 
      Georgia-Augusta University, Augusta, Georgia, USA.
LA  - eng
PT  - Journal Article
DEP - 20210417
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
SB  - IM
MH  - *Asthma, Aspirin-Induced
MH  - Chronic Disease
MH  - Humans
MH  - *Nasal Polyps
MH  - *Rhinitis
MH  - *Rhinitis, Allergic
MH  - *Sinusitis
OTO - NOTNLM
OT  - chronic rhinosinusitis
OT  - eosinophilic rhinitis and nasal polyposis
OT  - imaging
EDAT- 2021/04/18 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/04/17 17:04
PHST- 2021/03/23 00:00 [revised]
PHST- 2021/01/11 00:00 [received]
PHST- 2021/03/27 00:00 [accepted]
PHST- 2021/04/18 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/04/17 17:04 [entrez]
AID - 10.1002/alr.22803 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2021 Oct;11(10):1417-1423. doi: 10.1002/alr.22803. Epub 
      2021 Apr 17.