PMID- 33865297
OWN - NLM
STAT- MEDLINE
DCOM- 20240325
LR  - 20240325
IS  - 0125-877X (Print)
IS  - 0125-877X (Linking)
VI  - 42
IP  - 1
DP  - 2024 Mar
TI  - Relationship between the outcome of low-dose egg oral immunotherapy and the 
      fold-difference levels of allergen-specific IgE and IgG4 in serum.
PG  - 36-42
LID - 10.12932/AP-100620-0877 [doi]
AB  - BACKGROUND: There are no indices to monitor desensitization by low-dose egg oral 
      immunotherapy (eOIT). OBJECTIVE: We aimed to examine the relationship between 
      desensitization by low-dose eOIT and the changes in allergen-specific 
      immunoglobulin E (IgE) and IgG4 levels. METHODS: We carried out low-dose eOIT in 
      31 patients with severe egg allergy in our previous two studies. After 4 months 
      of treatment, the patients with no observed allergic symptoms in response to the 
      open hard-boiled egg white challenge tests were classified as the negative group, 
      and the remaining patients, the positive group. The fold-difference levels were 
      calculated using 10 Log (Titer after eOIT/Titer before eOIT). RESULTS: The 28 
      patients who completed eOIT with sufficient serum collected before and after eOIT 
      were analyzed. The median fold-difference levels of ovomucoid-specific IgE in the 
      negative and positive groups were 0.819 and 0.953, respectively (P = 0.082). The 
      median fold-difference levels of ovalbumin-specific IgG4 in the negative and 
      positive groups were 2.01 and 1.29, respectively (P = 0.057). In the 
      receiver-operating characteristic curves, the area under the curves of 
      fold-difference ovomucoid-specific IgE and ovalbumin-specific IgG4 were 0.701 and 
      0.719, respectively. The challenge positive predictive values of fold-difference 
      ovomucoid-specific IgE and ovalbumin-specific IgG4 were 83.8% (cut-off point: 
      0.934) and 77.8% (cut-off point: 1.87), respectively. Moreover, the challenge 
      positive predictive value in patients with both 0.934 < ovomucoid-specific IgE 
      and ovalbumin-specific IgG4 <1.87 was 100%. CONCLUSIONS: The fold-difference 
      levels of allergen-specific IgE and IgG4 in serum are considered useful for 
      monitoring desensitization by low-dose OIT.
FAU - Maeta, Akihiro
AU  - Maeta A
AD  - Department of Food Science and Nutrition, School of Food Science and Nutrition, 
      Mukogawa Women's University, Hyogo, Japan.
FAU - Takaoka, Yuri
AU  - Takaoka Y
AD  - Department of Pediatrics, Osaka Prefectural Hospital Organization Osaka Habikino 
      Medical Center, Osaka, Japan.
FAU - Kameda, Makoto
AU  - Kameda M
AD  - Department of Pediatrics, Osaka Prefectural Hospital Organization Osaka Habikino 
      Medical Center, Osaka, Japan.
FAU - Takahashi, Kyoko
AU  - Takahashi K
AD  - Department of Food Science and Nutrition, School of Food Science and Nutrition, 
      Mukogawa Women's University, Hyogo, Japan.
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Allergy Immunol
JT  - Asian Pacific journal of allergy and immunology
JID - 8402034
RN  - 0 (Immunoglobulin G)
RN  - 9006-59-1 (Ovalbumin)
RN  - 37281-36-0 (Ovomucin)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Allergens)
SB  - IM
MH  - Humans
MH  - *Immunoglobulin G
MH  - Ovalbumin
MH  - *Ovomucin
MH  - Treatment Outcome
MH  - Desensitization, Immunologic
MH  - Immunoglobulin E
MH  - Allergens
EDAT- 2021/04/19 06:00
MHDA- 2024/03/25 06:44
CRDT- 2021/04/18 20:19
PHST- 2024/03/25 06:44 [medline]
PHST- 2021/04/19 06:00 [pubmed]
PHST- 2021/04/18 20:19 [entrez]
AID - 10.12932/AP-100620-0877 [doi]
PST - ppublish
SO  - Asian Pac J Allergy Immunol. 2024 Mar;42(1):36-42. doi: 10.12932/AP-100620-0877.