PMID- 33866261
OWN - NLM
STAT- MEDLINE
DCOM- 20210705
LR  - 20210705
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 231
DP  - 2021 May
TI  - Neutrophils to lymphocytes ratio and psychosis in 22q11.2 deletion syndrome - 
      Clinical and scientific implications.
PG  - 164-169
LID - S0920-9964(21)00149-3 [pii]
LID - 10.1016/j.schres.2021.03.023 [doi]
AB  - BACKGROUND: Individuals with 22q11.2 deletion syndrome (22q11.2DS) are at risk 
      for having both psychotic and immune disorders, thus, implying a possible link 
      between the two. The aim of the current study was to evaluate the usefulness of 
      the neutrophiles to leukocytes ratio (NLR), an inflammatory marker, as a 
      bio-marker for overt and prodromal psychotic symptoms in 22q11.2DS. METHODS: 
      Forty-nine individuals with 22q11.2DS (13 with psychotic disorders and 36 without 
      psychotic disorders) and 30 age- and sex-matched healthy controls underwent 
      psychiatric evaluation using a structured psychiatric interview, the Scale of 
      Prodromal Symptoms (SOPS) and the Global Assessment of Functioning (GAF) scale. 
      Blood samples were collected from all participants on the day of assessment. NLR 
      was calculated, compared among the study groups and correlated with SOPS and GAF 
      scores. The non-psychotic 22q11.2DS group was further divided into high- and 
      low-inflammation groups by NLR values and the analyses were done again. RESULTS: 
      NLR was higher in the psychotic- and the high-inflammation non-psychotic 
      22q11.2DS groups compared to the low-inflammation non-psychotic 22q11.2DS group 
      and controls. In the high-inflammation non-psychotic 22q11.2DS group NLR increase 
      was associated with an increase of total negative symptoms scores on SOPS and a 
      decrease in GAF scores. CONCLUSION: Our results suggest the potential utility of 
      NLR as a bio-marker for psychotic disorders and subthreshold prodromal symptoms 
      in 22q11.2DS. Furthermore, they imply that a disequilibrium between the innate 
      and adaptive arms of the immune system facilitates the progression of psychosis 
      in at risk populations. Further longitudinal studies are warranted to validate 
      our findings, as this was a cross sectional observation.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Mekori-Domachevsky, Ehud
AU  - Mekori-Domachevsky E
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; The Child and 
      Adolescent Psychiatry Division, Safra Children's Hospital, Sheba Medical Center, 
      Ramat Gan, Israel. Electronic address: ehud.mekori@sheba.gov.il.
FAU - Taler, Michal
AU  - Taler M
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Laboratory of 
      Biological Psychiatry, Felsenstein Medical Research Center, Petah Tikva, Israel; 
      Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
FAU - Weinberger, Ronnie
AU  - Weinberger R
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Guri, Yael
AU  - Guri Y
AD  - Eitanim Mental Health Center, Jerusalem, Israel.
FAU - Dar, Shira
AU  - Dar S
AD  - Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Petah 
      Tikva, Israel.
FAU - Shani, Shachar
AU  - Shani S
AD  - Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
FAU - Dekel, Idit
AU  - Dekel I
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; The Child and 
      Adolescent Psychiatry Division, Safra Children's Hospital, Sheba Medical Center, 
      Ramat Gan, Israel.
FAU - Weizman, Abraham
AU  - Weizman A
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Sagol School 
      of Neuroscience, Tel Aviv University, Tel Aviv, Israel; Geha Mental Health 
      Center, Petach Tikva, Israel.
FAU - Gothelf, Doron
AU  - Gothelf D
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; The Child and 
      Adolescent Psychiatry Division, Safra Children's Hospital, Sheba Medical Center, 
      Ramat Gan, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, 
      Israel.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210416
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Cross-Sectional Studies
MH  - *DiGeorge Syndrome/complications
MH  - Humans
MH  - Lymphocytes
MH  - Neutrophils
MH  - *Psychotic Disorders
OTO - NOTNLM
OT  - 22q11.2 deletion syndrome
OT  - Inflammation
OT  - Neutrophils lymphocytes ratio
OT  - Psychosis
OT  - Schizophrenia
COIS- Declaration of competing interest All of the authors declare that there are no 
      conflicts of interest pertaining to this study.
EDAT- 2021/04/19 06:00
MHDA- 2021/07/06 06:00
CRDT- 2021/04/18 20:53
PHST- 2020/12/05 00:00 [received]
PHST- 2021/03/13 00:00 [revised]
PHST- 2021/03/30 00:00 [accepted]
PHST- 2021/04/19 06:00 [pubmed]
PHST- 2021/07/06 06:00 [medline]
PHST- 2021/04/18 20:53 [entrez]
AID - S0920-9964(21)00149-3 [pii]
AID - 10.1016/j.schres.2021.03.023 [doi]
PST - ppublish
SO  - Schizophr Res. 2021 May;231:164-169. doi: 10.1016/j.schres.2021.03.023. Epub 2021 
      Apr 16.