PMID- 33866362
OWN - NLM
STAT- MEDLINE
DCOM- 20220228
LR  - 20220228
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 31
IP  - 7
DP  - 2021 Jun 10
TI  - Activation of Person Knowledge in Medial Prefrontal Cortex during the Encoding of 
      New Lifelike Events.
PG  - 3494-3505
LID - 10.1093/cercor/bhab027 [doi]
AB  - Our knowledge about people can help us predict how they will behave in particular 
      situations and interpret their actions. In this study, we investigated the 
      cognitive and neural effects of person knowledge on the encoding and retrieval of 
      novel life-like events. Healthy human participants learnt about two characters 
      over a week by watching 6 episodes of one of two situation comedies, which were 
      both centered on a young couple. In the scanner, they watched and then silently 
      recalled 20 new scenes from both shows that were all set in unfamiliar locations: 
      10 from their trained show and 10 from the untrained show. After scanning, 
      participants' recognition memory was better for scenes from the trained show. The 
      functional magnetic resonance imaging (fMRI) patterns of brain activity when 
      watching the videos were reinstated during recall, but this effect was not 
      modulated by training. However, person knowledge boosted the similarity in fMRI 
      patterns of activity in the medial prefrontal cortex (MPFC) when watching the new 
      events involving familiar characters. Our findings identify a role for the MPFC 
      in the representation of schematic person knowledge during the encoding of novel, 
      lifelike events.
CI  - (c) The Author(s) 2021. Published by Oxford University Press.
FAU - Raykov, Petar P
AU  - Raykov PP
AUID- ORCID: 0000-0002-2124-2995
AD  - School of Psychology, University of Sussex, Falmer BN1 9QH, UK.
FAU - Keidel, James L
AU  - Keidel JL
AD  - School of Psychology, University of Sussex, Falmer BN1 9QH, UK.
FAU - Oakhill, Jane
AU  - Oakhill J
AD  - School of Psychology, University of Sussex, Falmer BN1 9QH, UK.
FAU - Bird, Chris M
AU  - Bird CM
AUID- ORCID: 0000-0002-8183-5688
AD  - School of Psychology, University of Sussex, Falmer BN1 9QH, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/diagnostic imaging/physiology
MH  - Concept Formation/*physiology
MH  - Female
MH  - Functional Neuroimaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Prefrontal Cortex/*diagnostic imaging/physiology
MH  - Recognition, Psychology/*physiology
MH  - Young Adult
PMC - PMC8355471
OTO - NOTNLM
OT  - fMRI
OT  - medial prefrontal cortex
OT  - memory
OT  - prior knowledge
OT  - schema
EDAT- 2021/04/19 06:00
MHDA- 2022/03/01 06:00
PMCR- 2021/04/19
CRDT- 2021/04/18 20:58
PHST- 2020/09/15 00:00 [received]
PHST- 2021/01/21 00:00 [revised]
PHST- 2021/01/21 00:00 [accepted]
PHST- 2021/04/19 06:00 [pubmed]
PHST- 2022/03/01 06:00 [medline]
PHST- 2021/04/18 20:58 [entrez]
PHST- 2021/04/19 00:00 [pmc-release]
AID - 6236062 [pii]
AID - bhab027 [pii]
AID - 10.1093/cercor/bhab027 [doi]
PST - ppublish
SO  - Cereb Cortex. 2021 Jun 10;31(7):3494-3505. doi: 10.1093/cercor/bhab027.