PMID- 33866923
OWN - NLM
STAT- MEDLINE
DCOM- 20220301
LR  - 20220429
IS  - 1555-8584 (Electronic)
IS  - 1547-6286 (Print)
IS  - 1547-6286 (Linking)
VI  - 18
IP  - 12
DP  - 2021 Dec
TI  - TTP-mediated regulation of mRNA stability in immune cells contributes to adaptive 
      immunity, immune tolerance and clinical applications.
PG  - 2150-2156
LID - 10.1080/15476286.2021.1917185 [doi]
AB  - Dendritic cells (DCs) form a sentinel network to induce protective immunity 
      against pathogens or self-tolerance. mRNA stability is an important part of the 
      post-transcriptional regulation (PTR) that controls the maturation and function 
      of DCs. In this review, we summarize the effects of TTP-mediated regulation of 
      mRNA stability in DCs, focusing on DC maturation and antigen presentation, T cell 
      activation and differentiation, immune tolerance and inflammation. We also 
      discuss the potential DC-based immune treatment for HIV(+) patients through 
      regulation of mRNA stability. This review proposes the regulation of mRNA 
      stability as a novel immune therapy for various inflammatory diseases, such as 
      arthritis and dermatitis.
FAU - Zhang, Yiwei
AU  - Zhang Y
AD  - Institute of Immunology, PLA, Third Military Medical University (Army Medical 
      University), Chongqing, PR China.
FAU - Zhou, Jian
AU  - Zhou J
AD  - Institute of Immunology, PLA, Third Military Medical University (Army Medical 
      University), Chongqing, PR China.
FAU - Wei, Zhiyuan
AU  - Wei Z
AUID- ORCID: 0000-0002-8795-6878
AD  - Department of Orthopedics, The First Affiliated Hospital of Third Military 
      Medical University (Army Medical University), Chongqing, PR China.
FAU - Dong, Hui
AU  - Dong H
AD  - Institute of Immunology, PLA, Third Military Medical University (Army Medical 
      University), Chongqing, PR China.
FAU - Yang, Di
AU  - Yang D
AD  - Institute of Immunology, PLA, Third Military Medical University (Army Medical 
      University), Chongqing, PR China.
FAU - Deng, Yuanyu
AU  - Deng Y
AD  - School of Basic Medicine, Third Military Medical University (Army Medical 
      University), Chongqing, PR China.
FAU - Li, Jiahui
AU  - Li J
AD  - School of Basic Medicine, Third Military Medical University (Army Medical 
      University), Chongqing, PR China.
FAU - Shi, Saiyu
AU  - Shi S
AD  - School of Basic Medicine, Third Military Medical University (Army Medical 
      University), Chongqing, PR China.
FAU - Sun, Yi
AU  - Sun Y
AD  - The First Affiliated Hospital of Third Military Medical University (Army Medical 
      University), Chongqing, PR China.
FAU - Lu, Huimin
AU  - Lu H
AD  - The First Affiliated Hospital of Third Military Medical University (Army Medical 
      University), Chongqing, PR China.
FAU - Yuan, Jizhao
AU  - Yuan J
AD  - Institute of Immunology, PLA, Third Military Medical University (Army Medical 
      University), Chongqing, PR China.
FAU - Ni, Bing
AU  - Ni B
AD  - Department of Pathophysiology, Third Military Medical University (Army Medical 
      University), Chongqing, PR China.
FAU - Wu, Yuzhang
AU  - Wu Y
AD  - Institute of Immunology, PLA, Third Military Medical University (Army Medical 
      University), Chongqing, PR China.
AD  - Department of Orthopedics, The First Affiliated Hospital of Third Military 
      Medical University (Army Medical University), Chongqing, PR China.
FAU - Tian, Yi
AU  - Tian Y
AD  - Institute of Immunology, PLA, Third Military Medical University (Army Medical 
      University), Chongqing, PR China.
AD  - School of Basic Medicine, Third Military Medical University (Army Medical 
      University), Chongqing, PR China.
FAU - Han, Chao
AU  - Han C
AD  - Institute of Immunology, PLA, Third Military Medical University (Army Medical 
      University), Chongqing, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210427
PL  - United States
TA  - RNA Biol
JT  - RNA biology
JID - 101235328
RN  - 0 (RNA, Messenger)
RN  - 0 (Tristetraprolin)
RN  - 0 (ZFP36 protein, human)
SB  - IM
MH  - Adaptive Immunity
MH  - Antigen Presentation
MH  - Dendritic Cells/*metabolism
MH  - HIV Infections/genetics/*immunology
MH  - Humans
MH  - Immune Tolerance
MH  - RNA Stability
MH  - RNA, Messenger/*chemistry
MH  - Tristetraprolin/*metabolism
PMC - PMC8632132
OTO - NOTNLM
OT  - Dendritic cells
OT  - TTP
OT  - Zfp36
OT  - adaptive immunity
OT  - clinical application
OT  - immune tolerance
OT  - mRNA stability
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2021/04/20 06:00
MHDA- 2022/03/03 06:00
PMCR- 2022/04/27
CRDT- 2021/04/19 05:28
PHST- 2021/04/20 06:00 [pubmed]
PHST- 2022/03/03 06:00 [medline]
PHST- 2021/04/19 05:28 [entrez]
PHST- 2022/04/27 00:00 [pmc-release]
AID - 1917185 [pii]
AID - 10.1080/15476286.2021.1917185 [doi]
PST - ppublish
SO  - RNA Biol. 2021 Dec;18(12):2150-2156. doi: 10.1080/15476286.2021.1917185. Epub 
      2021 Apr 27.