PMID- 33867017
OWN - NLM
STAT- MEDLINE
DCOM- 20210831
LR  - 20210831
IS  - 0168-9525 (Print)
IS  - 0168-9525 (Electronic)
IS  - 0168-9525 (Linking)
VI  - 37
IP  - 5
DP  - 2021 May
TI  - Self-Peptidome Variation Shapes Individual Immune Responses.
PG  - 414-420
LID - S0168-9525(20)30274-2 [pii]
LID - 10.1016/j.tig.2020.10.001 [doi]
AB  - The relationship between human genetic variation and disease has not been fully 
      elucidated. According to the present view on infectious diseases pathogen 
      resistance is linked to human leukocyte antigen (HLA) class I/II variants and 
      their individual capacity to present pathogen-derived peptides. Yet, T cell 
      education in the thymus occurs through negative and positive selection, and both 
      processes are controlled by a combination of HLA class I/II variants and peptides 
      from the self. Therefore, the capacity of given HLA class I/II variants to bind 
      pathogen-derived peptides is only one part of the selective process to generate 
      effective immune responses. We thus propose that peptidome variation contributes 
      to shaping T cell receptor (TCR) repertoires and hence individual immune 
      responses, and that this variation represents inherent modulator epitopes.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Pontarotti, Pierre
AU  - Pontarotti P
AD  - Aix Marseille Universite, IRD, APHM, MEPHI, IHU Mediterranee Infection, 19-21 
      Boulevard Jean Moulin, 13005 Marseille, France; SNC5039 CNRS, 19-21 Boulevard 
      Jean Moulin, 13005 Marseille, France; XEGEN, 15 rue Dominique Piazza, 13420 
      Gemenos, France. Electronic address: Pierre.pontarotti@univ-amu.fr.
FAU - Abi-Rached, Laurent
AU  - Abi-Rached L
AD  - Aix Marseille Universite, IRD, APHM, MEPHI, IHU Mediterranee Infection, 19-21 
      Boulevard Jean Moulin, 13005 Marseille, France; SNC5039 CNRS, 19-21 Boulevard 
      Jean Moulin, 13005 Marseille, France.
FAU - Yeh, Jung-Hua
AU  - Yeh JH
AD  - Prokarium Ltd., London Bioscience Innovation Centre, 2 Royal College Street, 
      London NW1 0NH, UK.
FAU - Paganini, Julien
AU  - Paganini J
AD  - XEGEN, 15 rue Dominique Piazza, 13420 Gemenos, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201021
PL  - England
TA  - Trends Genet
JT  - Trends in genetics : TIG
JID - 8507085
RN  - 0 (Epitopes)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Peptides)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Disease Susceptibility
MH  - Epitopes
MH  - Histocompatibility Antigens Class I/genetics/*immunology
MH  - Histocompatibility Antigens Class II/genetics/immunology
MH  - Humans
MH  - Immunity/*physiology
MH  - Peptides/*genetics/*immunology/metabolism
MH  - Polymorphism, Genetic
MH  - Receptors, Antigen, T-Cell/immunology
PMC - PMC7577255
OTO - NOTNLM
OT  - HLA
OT  - T cell receptor
OT  - disease
OT  - immune responses
OT  - inherent modulator epitopes
OT  - peptide
EDAT- 2021/04/20 06:00
MHDA- 2021/09/01 06:00
PMCR- 2020/10/21
CRDT- 2021/04/19 05:32
PHST- 2020/07/06 00:00 [received]
PHST- 2020/09/28 00:00 [revised]
PHST- 2020/10/01 00:00 [accepted]
PHST- 2021/04/19 05:32 [entrez]
PHST- 2021/04/20 06:00 [pubmed]
PHST- 2021/09/01 06:00 [medline]
PHST- 2020/10/21 00:00 [pmc-release]
AID - S0168-9525(20)30274-2 [pii]
AID - 10.1016/j.tig.2020.10.001 [doi]
PST - ppublish
SO  - Trends Genet. 2021 May;37(5):414-420. doi: 10.1016/j.tig.2020.10.001. Epub 2020 
      Oct 21.