PMID- 33868608
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220422
IS  - 2008-2258 (Print)
IS  - 2008-4234 (Electronic)
IS  - 2008-2258 (Linking)
VI  - 14
IP  - 1
DP  - 2021 Winter
TI  - The frequency of HLA-DQ2/DQ8 haplotypes and celiac disease among the first-degree 
      relatives of patients with celiac disease.
PG  - 36-43
AB  - AIM: We evaluated the frequency of human leukocyte antigen (HLA) DQ2/DQ8 
      haplotypes as well as celiac disease (CD) among the first-degree relatives (FDRs) 
      of CD patients, compared with healthy controls, and compared the HLA typing with 
      serologic tests in this population. BACKGROUND: Until now, no study has examined 
      the frequency of HLA-DQ2/DQ8 haplotypes among the FDRs of Iranian patients with 
      CD. METHODS: In the current case-control study, 100 FDRs of CD patients and 151 
      healthy controls were included. Demographic characteristics were assessed using a 
      research-made questionnaire. A blood sample was collected from each participant 
      for HLA-DQ typing and measuring serum levels of anti-gliadin and 
      anti-transglutaminase (anti-tTG) antibodies. RESULTS: The mean age of the FDRs of 
      CD patients and controls was 30 and 35 years, respectively. Also, 51% (n=51) of 
      the FDRs and 51.7% (n=78) of controls were female. CD was diagnosed among 3% 
      (n=3) of the FDRs of CD patients. No significant difference was found in terms of 
      the frequency of HLA-DQ alleles between the FDRs of CD patients and controls. Out 
      of 100 FDRs of CD patients, 40% had HLA-DQ2 allele, 16% carried HLA-DQ8 allele, 
      and 4% had both alleles. Surprisingly, the CD was diagnosed in three subjects 
      among 60 FDRs of CD patients with HLA-DQ2 allele (3% of the whole population). 
      This diagnosis was based on the results of serological tests as well as endoscopy 
      and intestinal biopsy. CONCLUSION: CD was confirmed among 3% (n=3) of the FDRs of 
      CD patients. We found that HLA typing is not effective in predicting CD among 
      FDRs of CD patients. Other methods such as serological tests have a higher 
      priority compared with HLA-DQ typing.
CI  - (c)2021 RIGLD, Research Institute for Gastroenterology and Liver Diseases.
FAU - Mansouri, Masoume
AU  - Mansouri M
AD  - Digestive Disease Research Center, Digestive Diseases Research Institute, Tehran 
      University of Medical Sciences, Shariati Hospital, Tehran, Iran.
AD  - Health Center of Tarbiat Modares University, Tehran, Iran.
FAU - Dadfar, Masoud
AU  - Dadfar M
AD  - Digestive Disease Research Center, Digestive Diseases Research Institute, Tehran 
      University of Medical Sciences, Shariati Hospital, Tehran, Iran.
FAU - Rostami-Nejad, Mohammad
AU  - Rostami-Nejad M
AD  - Gastroenterology and Liver Diseases Research Center, Research Institute for 
      Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Ekhlasi, Golnaz
AU  - Ekhlasi G
AD  - Digestive Disease Research Center, Digestive Diseases Research Institute, Tehran 
      University of Medical Sciences, Shariati Hospital, Tehran, Iran.
FAU - Shahbazkhani, Amirhossein
AU  - Shahbazkhani A
AD  - Sina hospital, Tehran University of Medical Science, Tehran, Iran.
FAU - Shahbazkhani, Bijan
AU  - Shahbazkhani B
AD  - Digestive Disease Research Center, Digestive Diseases Research Institute, Tehran 
      University of Medical Sciences, Shariati Hospital, Tehran, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Gastroenterol Hepatol Bed Bench
JT  - Gastroenterology and hepatology from bed to bench
JID - 101525875
PMC - PMC8035532
OTO - NOTNLM
OT  - Celiac disease
OT  - HLA typing
OT  - HLA-DQ2
OT  - HLA-DQ8
OT  - Iran
EDAT- 2021/04/20 06:00
MHDA- 2021/04/20 06:01
PMCR- 2021/01/01
CRDT- 2021/04/19 06:25
PHST- 2021/04/19 06:25 [entrez]
PHST- 2021/04/20 06:00 [pubmed]
PHST- 2021/04/20 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - GHFBB-14-36 [pii]
PST - ppublish
SO  - Gastroenterol Hepatol Bed Bench. 2021 Winter;14(1):36-43.