PMID- 33868686
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220422
IS  - 2049-0801 (Print)
IS  - 2049-0801 (Electronic)
IS  - 2049-0801 (Linking)
VI  - 65
DP  - 2021 May
TI  - High-fat diet increases the level of circulating Monocyte Chemoattractant 
      Protein-1 in Wistar rats, independent of obesity.
PG  - 102266
LID - 10.1016/j.amsu.2021.102266 [doi]
LID - 102266
AB  - INTRODUCTION: Low-grade chronic in fl ammation has emerged as a key pathogenic link 
      between high-fat diet (HFD)-induced obesity and the increased risk of chronic 
      diseases. Evidence has shown that HFDs may induce inflammation in the central 
      nervous system and peripheral tissues. Monocyte Chemoattractant Protein-1 (MCP-1) 
      is a product of various cells that is known to be an inflammatory marker. This 
      study investigated whether a HFD could induce obesity and increase the level of 
      MCP-1 in Wistar rats. METHODS: The Wistar rats were randomized into two groups: 
      normal diet (ND) and HFD (n = 12 per group). Both groups were fed for 8 and 16 
      weeks, thus dividing the rats into 4 arms: ND8, ND16, HFD8, and HFD16 (n = 6 per 
      sub-group). Obesity in rats was measured using the Lee index. Blood samples were 
      taken to measure the level of MCP-1. RESULTS: Our results showed that obesity did 
      not occur in the group with a normal diet (ND8 and ND16). However, in the HFD 
      group (HFD8 and HFD16), 4 of the 6 rats became obese. However, MCP-1 was 
      significantly higher among non-obese rats in the HFD group compared with the ND 
      group (p < 0.001). CONCLUSION: HFDs have been shown to increase the risk of 
      obesity. In addition, increases in circulating MCP-1 were significantly different 
      between Wistar rats given a HFD compared with the ND group.
CI  - (c) 2021 The Authors.
FAU - Syarif
AU  - Syarif
AD  - Division of Urology, Department of Surgery, Faculty of Medicine, Hasanuddin 
      University, Makassar, Indonesia.
FAU - Rasyid, Haerani
AU  - Rasyid H
AD  - Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, 
      Makassar, Indonesia.
FAU - Aman, Makbul
AU  - Aman M
AD  - Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, 
      Makassar, Indonesia.
FAU - Lawrence, Gatot S
AU  - Lawrence GS
AD  - Department of Pathology Anatomy, Faculty of Medicine, Hasanuddin University, 
      Makassar, Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20210401
PL  - England
TA  - Ann Med Surg (Lond)
JT  - Annals of medicine and surgery (2012)
JID - 101616869
PMC - PMC8047162
OTO - NOTNLM
OT  - Diet-induced obesity
OT  - Experimental animal models
OT  - High-fat diet
OT  - Monocyte chemoattractant Protein-1
OT  - Wistar rat
COIS- The authors declare that they have no conflict of interests.
EDAT- 2021/04/20 06:00
MHDA- 2021/04/20 06:01
PMCR- 2021/04/01
CRDT- 2021/04/19 06:26
PHST- 2021/02/10 00:00 [received]
PHST- 2021/03/24 00:00 [revised]
PHST- 2021/03/24 00:00 [accepted]
PHST- 2021/04/19 06:26 [entrez]
PHST- 2021/04/20 06:00 [pubmed]
PHST- 2021/04/20 06:01 [medline]
PHST- 2021/04/01 00:00 [pmc-release]
AID - S2049-0801(21)00216-8 [pii]
AID - 102266 [pii]
AID - 10.1016/j.amsu.2021.102266 [doi]
PST - epublish
SO  - Ann Med Surg (Lond). 2021 Apr 1;65:102266. doi: 10.1016/j.amsu.2021.102266. 
      eCollection 2021 May.