PMID- 33868749
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220328
IS  - 2092-6456 (Electronic)
IS  - 1226-7708 (Print)
IS  - 1226-7708 (Linking)
VI  - 30
IP  - 3
DP  - 2021 Mar
TI  - Comparing the stability of retinol in liposomes with cholesterol, beta-sitosterol, 
      and stigmasterol.
PG  - 389-394
LID - 10.1007/s10068-020-00871-y [doi]
AB  - In this study, cholesterol (CH), beta-sitosterol (SI), and stigmasterol (ST) were 
      explored to improve the stability of retinol in the liposome bilayer. Retinol was 
      incorporated into liposomes composed of soybean-derived L-alpha-phosphatidylcholine 
      (PC) and 10% sterol (w/w), which were prepared as multilamellar vesicles. Under 
      all conditions, the efficiency of retinol incorporation into liposomes was higher 
      than 99%, and the average particle size of liposomes was similar to that of PC 
      alone. Liposomes were stored at 4 and 25  degrees C, with and without light, 
      respectively, for 10 days. It was found that during the storage, CH and SI were 
      effective in stabilizing the retinol in liposomes. These results indicate that an 
      appropriate phytosterol could improve the stability of retinol in liposomes.
CI  - (c) The Korean Society of Food Science and Technology 2021.
FAU - Lee, Dong-Uk
AU  - Lee DU
AD  - School of Bioconvergence, Kyungnam University, Kyungnamdaehak-ro 7, Changwon, 
      51767 Korea. GRID: grid.440959.5. ISNI: 0000 0001 0742 9537
FAU - Park, Hye-Won
AU  - Park HW
AD  - School of Bioconvergence, Kyungnam University, Kyungnamdaehak-ro 7, Changwon, 
      51767 Korea. GRID: grid.440959.5. ISNI: 0000 0001 0742 9537
FAU - Lee, Seung-Cheol
AU  - Lee SC
AUID- ORCID: 0000-0003-4145-0529
AD  - School of Bioconvergence, Kyungnam University, Kyungnamdaehak-ro 7, Changwon, 
      51767 Korea. GRID: grid.440959.5. ISNI: 0000 0001 0742 9537
LA  - eng
PT  - Journal Article
DEP - 20210327
PL  - Korea (South)
TA  - Food Sci Biotechnol
JT  - Food science and biotechnology
JID - 9816587
PMC - PMC8017050
OTO - NOTNLM
OT  - Liposome
OT  - Phytosterol
OT  - Retinol
OT  - Stability
COIS- Conflict of interestThe authors declared that they have no conflict of interest.
EDAT- 2021/04/20 06:00
MHDA- 2021/04/20 06:01
PMCR- 2022/03/27
CRDT- 2021/04/19 06:28
PHST- 2020/06/15 00:00 [received]
PHST- 2020/12/01 00:00 [revised]
PHST- 2020/12/23 00:00 [accepted]
PHST- 2021/04/19 06:28 [entrez]
PHST- 2021/04/20 06:00 [pubmed]
PHST- 2021/04/20 06:01 [medline]
PHST- 2022/03/27 00:00 [pmc-release]
AID - 871 [pii]
AID - 10.1007/s10068-020-00871-y [doi]
PST - epublish
SO  - Food Sci Biotechnol. 2021 Mar 27;30(3):389-394. doi: 10.1007/s10068-020-00871-y. 
      eCollection 2021 Mar.