PMID- 33873233
OWN - NLM
STAT- MEDLINE
DCOM- 20211203
LR  - 20211214
IS  - 1526-4564 (Electronic)
IS  - 1526-4564 (Linking)
VI  - 38
IP  - 6
DP  - 2020 Nov
TI  - Obesity and the Risk of Infertility, Gestational Diabetes, and Type 2 Diabetes in 
      Polycystic Ovary Syndrome.
PG  - 342-351
LID - 10.1055/s-0041-1726866 [doi]
AB  - This review describes the relationship between obesity and the most common 
      reproductive (infertility) and metabolic (gestational diabetes mellitus [GDM] and 
      type 2 diabetes mellitus [T2DM]) consequences in polycystic ovary syndrome 
      (PCOS). It also describes the vital role of lifestyle management for PCOS. PCOS 
      is a heterogeneous endocrine disorder common in reproductive-age women. Consensus 
      on the exact etiological mechanisms of PCOS is unreached. Overweight or obesity 
      is present in at least 60% of the PCOS population, but the condition occurs 
      irrespective of BMI, with excess BMI increasing both the prevalence and severity 
      of clinical features. Use of lifestyle therapies (nutrition, physical activity, 
      and/or behavioral) for the prevention and management of excess weight gain, 
      infertility, GDM, and T2DM is a vital component of best-practice PCOS care. 
      Lifestyle management is recommended for all women with PCOS as the first-line 
      treatment with or without medications. Due to a lack of high-quality trials 
      demonstrating the efficacy of specific lifestyle approaches, PCOS lifestyle 
      recommendations are as those for the general population. This review summarizes 
      current knowledge relating to obesity and its impact on fertility, GDM, and T2DM. 
      It also summarizes the lifestyle recommendations to best manage these conditions 
      in women with PCOS and obesity.
CI  - Thieme. All rights reserved.
FAU - Pirotta, Stephanie
AU  - Pirotta S
AUID- ORCID: 0000-0002-8966-0296
AD  - Health and Social Care Unit, SPHPM, Monash University, Victoria, Australia.
FAU - Joham, Anju
AU  - Joham A
AUID- ORCID: 0000-0002-6307-2568
AD  - Monash Centre for Health Research and Implementation, Monash University, 
      Victoria, Australia.
AD  - Department of Diabetes and Vascular Medicine, Monash Health, Victoria, Australia.
FAU - Grieger, Jessica A
AU  - Grieger JA
AD  - Adelaide Medical School, University of Adelaide, South Australia, Australia.
AD  - Robinson Research Institute, University of Adelaide, Adelaide, Australia.
FAU - Tay, Chau Tien
AU  - Tay CT
AUID- ORCID: 0000-0001-6228-2654
AD  - Monash Centre for Health Research and Implementation, Monash University, 
      Victoria, Australia.
FAU - Bahri-Khomami, Mahnaz
AU  - Bahri-Khomami M
AD  - Monash Centre for Health Research and Implementation, Monash University, 
      Victoria, Australia.
FAU - Lujan, Marla
AU  - Lujan M
AUID- ORCID: 0000-0002-7203-5814
AD  - Division of Nutritional Sciences, Cornell University, New York.
FAU - Lim, Siew S
AU  - Lim SS
AUID- ORCID: 0000-0002-5333-6451
AD  - Monash Centre for Health Research and Implementation, Monash University, 
      Victoria, Australia.
FAU - Moran, Lisa J
AU  - Moran LJ
AUID- ORCID: 0000-0001-5772-6484
AD  - Monash Centre for Health Research and Implementation, Monash University, 
      Victoria, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210419
PL  - United States
TA  - Semin Reprod Med
JT  - Seminars in reproductive medicine
JID - 100909394
SB  - IM
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - *Diabetes, Gestational/epidemiology/therapy
MH  - Female
MH  - Humans
MH  - *Infertility
MH  - Obesity/complications/epidemiology/therapy
MH  - *Polycystic Ovary Syndrome/complications/epidemiology/therapy
MH  - Pregnancy
COIS- None declared.
EDAT- 2021/04/20 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/04/19 20:32
PHST- 2021/04/20 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/04/19 20:32 [entrez]
AID - 10.1055/s-0041-1726866 [doi]
PST - ppublish
SO  - Semin Reprod Med. 2020 Nov;38(6):342-351. doi: 10.1055/s-0041-1726866. Epub 2021 
      Apr 19.