PMID- 33880028
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220422
IS  - 1176-6328 (Print)
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 17
DP  - 2021
TI  - Electroacupuncture Ameliorates Depressive-Like Behaviors in Poststroke Rats via 
      Activating the tPA/BDNF/TrkB Pathway.
PG  - 1057-1067
LID - 10.2147/NDT.S298540 [doi]
AB  - BACKGROUND: Electroacupuncture (EA) is a form of physical therapy that has been 
      widely used in clinical practice in China. Post-stroke depression (PSD) is the 
      most common neuropsychiatric complication after stroke. EA has been shown to have 
      beneficial effects on PSD patients. However, the potential mechanism underlying 
      the protective effects of EA on PSD remains unclear. Here, we investigated 
      whether tissue plasminogen activator (tPA)/brain-derived neurotrophic factor 
      (BDNF)/tyrosine kinase receptor B (TrkB) signaling pathway participates in the 
      therapeutic effects of EA in a rat PSD model. METHODS: Experimental PSD was 
      induced by combining middle cerebral artery occlusion (MCAO) with chronic 
      unpredictable mild stimulation (CUMS) in adult male rats. Bodyweight gain, 
      neurological score, sucrose preference, and open field test were determined at 0, 
      7, 14, and 35 days after completing MCAO. The protein expressions of tPA, 
      precursor BDNF (proBDNF), mature BDNF (mBDNF), and TrkB were measured by 
      immunofluorescence and Western blot analysis. The tPA inhibitor plasminogen 
      inhibitor-1 (PAI-1) was used to explore whether tPA plays a crucial role in the 
      protective effects of EA on PSD. RESULTS: Compared with the sham rats, the PSD 
      rats showed decreased bodyweight, deteriorated neurological score, and 
      significant depressive-like behaviors. EA remarkably reversed bodyweight loss, 
      neurological deficit, and depressive-like behaviors in PSD rats. 
      Immunofluorescence staining and Western blot analysis showed that PSD-induced 
      decreased expression of tPA, mBDNF, and TrkB were prevented by EA. Furthermore, 
      we found that the effects of EA against PSD-induced depressive-like behaviors 
      were abolished by PAI-1, the specific inhibitor of tPA. CONCLUSION: Our results 
      suggest that the improvement in depressive-like behaviors induced by EA is likely 
      achieved via activation of the tPA/BDNF/TrkB pathway.
CI  - (c) 2021 Dong et al.
FAU - Dong, Hao
AU  - Dong H
AD  - Beijing Bo'ai Hospital, China Rehabilitation Research Center, China 
      Rehabilitation Science Institute, Beijing, People's Republic of China.
FAU - Qin, Yan-Qiang
AU  - Qin YQ
AD  - Treatment Center of TCM, Beijing Bo'ai Hospital, China Rehabilitation Research 
      Center, China Rehabilitation Science Institute, School of Rehabilitation 
      Medicine, Capital Medical University, Beijing, People's Republic of China.
FAU - Sun, Ying-Chun
AU  - Sun YC
AD  - Treatment Center of TCM, Beijing Bo'ai Hospital, China Rehabilitation Research 
      Center, China Rehabilitation Science Institute, School of Rehabilitation 
      Medicine, Capital Medical University, Beijing, People's Republic of China.
FAU - Yao, Hai-Jiang
AU  - Yao HJ
AD  - Treatment Center of TCM, Beijing Bo'ai Hospital, China Rehabilitation Research 
      Center, China Rehabilitation Science Institute, School of Rehabilitation 
      Medicine, Capital Medical University, Beijing, People's Republic of China.
FAU - Cheng, Xian-Kuan
AU  - Cheng XK
AD  - Treatment Center of TCM, Beijing Bo'ai Hospital, China Rehabilitation Research 
      Center, China Rehabilitation Science Institute, School of Rehabilitation 
      Medicine, Capital Medical University, Beijing, People's Republic of China.
FAU - Yu, Yan
AU  - Yu Y
AD  - Beijing Bo'ai Hospital, China Rehabilitation Research Center, China 
      Rehabilitation Science Institute, Beijing, People's Republic of China.
FAU - Lu, Shou-Si
AU  - Lu SS
AD  - Beijing Bo'ai Hospital, China Rehabilitation Research Center, China 
      Rehabilitation Science Institute, Beijing, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20210413
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC8053498
OTO - NOTNLM
OT  - chronic unpredictable mild stimulation
OT  - depressive-like behaviors
OT  - electroacupuncture
OT  - poststroke depression
OT  - tPA/BDNF/TrkB
COIS- The authors report no conflicts of interest in this work.
EDAT- 2021/04/22 06:00
MHDA- 2021/04/22 06:01
PMCR- 2021/04/13
CRDT- 2021/04/21 06:40
PHST- 2020/12/22 00:00 [received]
PHST- 2021/03/22 00:00 [accepted]
PHST- 2021/04/21 06:40 [entrez]
PHST- 2021/04/22 06:00 [pubmed]
PHST- 2021/04/22 06:01 [medline]
PHST- 2021/04/13 00:00 [pmc-release]
AID - 298540 [pii]
AID - 10.2147/NDT.S298540 [doi]
PST - epublish
SO  - Neuropsychiatr Dis Treat. 2021 Apr 13;17:1057-1067. doi: 10.2147/NDT.S298540. 
      eCollection 2021.