PMID- 33880616
OWN - NLM
STAT- MEDLINE
DCOM- 20211208
LR  - 20240402
IS  - 1863-2661 (Electronic)
IS  - 1863-2653 (Print)
IS  - 1863-2653 (Linking)
VI  - 226
IP  - 5
DP  - 2021 Jun
TI  - Acute stress reveals different impacts in male and female Zdhhc7-deficient mice.
PG  - 1613-1626
LID - 10.1007/s00429-021-02275-y [doi]
AB  - Numerous processes of neuronal development and synaptic plasticity in the brain 
      rely on the palmitoyl acyltransferase ZDHHC7, as it palmitoylates various 
      synaptic and extrasynaptic proteins such as neural cell adhesion molecule (NCAM) 
      or gamma-aminobutyric acid (GABA(A)) receptors. In addition, ZDHHC7 palmitoylates 
      sex steroid hormone receptors and is, therefore, indirectly linked to mental 
      disorders that often occur because of or in conjunction with stress. In this 
      work, we investigated how ZDHHC7 affects stress responses in mice. For this 
      purpose, genetically modified mice with a knockout of the Zdhhc7 gene (KO) and 
      wild-type (WT) littermates of both sexes were exposed to acute stressors or 
      control conditions and examined with regard to their behavior, brain 
      microstructure, gene expression, and synaptic plasticity. While no behavioral 
      effects of acute stress were found, we did find that acute stress caused reduced 
      mRNA levels of Esr1 and Esr2 coding for estrogen receptor alpha and beta in the medial 
      prefrontal cortex of male WT and KO mice. Strikingly, after acute stress only 
      male KO mice showed reduced mean fiber lengths of the medioventral hippocampus. 
      Furthermore, Zdhhc7-deficiency impaired synaptic plasticity in mice of both 
      sexes, while acute stress improved it in females, but not in male mice. Taken 
      together, our findings suggest that ZDHHC7 plays a modulatory role in the brain 
      that leads to sex-specific stress responses, possibly due to estrogen 
      receptor-mediated signaling pathways.
FAU - Kerkenberg, Nicole
AU  - Kerkenberg N
AUID- ORCID: 0000-0003-0565-0988
AD  - Department of Mental Health, University of Munster, Munster, Germany. 
      Nicole.Kerkenberg@ukmuenster.de.
AD  - Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of 
      Munster, Munster, Germany. Nicole.Kerkenberg@ukmuenster.de.
FAU - Hohoff, Christa
AU  - Hohoff C
AD  - Department of Mental Health, University of Munster, Munster, Germany.
FAU - Zhang, Mingyue
AU  - Zhang M
AD  - Department of Mental Health, University of Munster, Munster, Germany.
FAU - Lang, Ilona
AU  - Lang I
AD  - Department of Mental Health, University of Munster, Munster, Germany.
AD  - Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of 
      Munster, Munster, Germany.
FAU - Schettler, Christiane
AU  - Schettler C
AD  - Department of Mental Health, University of Munster, Munster, Germany.
FAU - Ponimaskin, Evgeni
AU  - Ponimaskin E
AD  - Cellular Neurophysiology, Hannover Medical School, Hannover, Germany.
FAU - Wachsmuth, Lydia
AU  - Wachsmuth L
AD  - Clinic of Radiology, University of Munster, Munster, Germany.
FAU - Faber, Cornelius
AU  - Faber C
AD  - Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of 
      Munster, Munster, Germany.
AD  - Clinic of Radiology, University of Munster, Munster, Germany.
FAU - Baune, Bernhard T
AU  - Baune BT
AD  - Department of Mental Health, University of Munster, Munster, Germany.
AD  - Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of 
      Munster, Munster, Germany.
AD  - Department of Psychiatry, Melbourne Medical School, University of Melbourne, 
      Melbourne, VIC, Australia.
AD  - Florey Institute for Neuroscience and Mental Health, University of Melbourne, 
      Melbourne, VIC, Australia.
FAU - Zhang, Weiqi
AU  - Zhang W
AD  - Department of Mental Health, University of Munster, Munster, Germany. 
      wzhang@uni-muenster.de.
AD  - Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of 
      Munster, Munster, Germany. wzhang@uni-muenster.de.
LA  - eng
GR  - Zha3-005-14/Interdisciplinary Centre for Clinical Research (IZKF)of the 
      University of Munster Medical School/
GR  - ZH 34/3-1/Deutsche Forschungsgemeinschaft/
GR  - core unit PIX/Interdisciplinary Centre for Clinical Research (IZKF) of the 
      University of Munster Medical School/
PT  - Journal Article
DEP - 20210420
PL  - Germany
TA  - Brain Struct Funct
JT  - Brain structure & function
JID - 101282001
RN  - 0 (Neural Cell Adhesion Molecules)
RN  - 0 (Receptors, GABA-A)
RN  - EC 2.3.- (Acyltransferases)
RN  - EC 2.3.1.- (Acetyltransferases)
SB  - IM
MH  - Acetyltransferases
MH  - Acyltransferases
MH  - Animals
MH  - Female
MH  - Hippocampus/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - Neural Cell Adhesion Molecules/metabolism
MH  - Neuronal Plasticity
MH  - Receptors, GABA-A
MH  - *Sex Characteristics
MH  - Stress, Physiological
PMC - PMC8096773
OTO - NOTNLM
OT  - Acute stress
OT  - Behavior
OT  - Eletrophysiological recordings
OT  - Palmitoylation
OT  - Small animal imaging
OT  - Zdhhc7-deficiency
COIS- The authors declare that they have no conflict of interest. No current external 
      funding sources for this study had any role in study design, data collection and 
      analysis, decision to publish, or preparation of the manuscript. Furthermore, the 
      authors do not have any competing interests.
EDAT- 2021/04/22 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/04/20
CRDT- 2021/04/21 06:52
PHST- 2020/10/23 00:00 [received]
PHST- 2021/04/09 00:00 [accepted]
PHST- 2021/04/22 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/04/21 06:52 [entrez]
PHST- 2021/04/20 00:00 [pmc-release]
AID - 10.1007/s00429-021-02275-y [pii]
AID - 2275 [pii]
AID - 10.1007/s00429-021-02275-y [doi]
PST - ppublish
SO  - Brain Struct Funct. 2021 Jun;226(5):1613-1626. doi: 10.1007/s00429-021-02275-y. 
      Epub 2021 Apr 20.