PMID- 33881215
OWN - NLM
STAT- MEDLINE
DCOM- 20210705
LR  - 20210705
IS  - 1479-8301 (Electronic)
IS  - 1346-3500 (Linking)
VI  - 21
IP  - 4
DP  - 2021 Jul
TI  - Behavioural disorders in Alzheimer's disease: the descriptive and predictive role 
      of brain (18) F-fluorodesoxyglucose-positron emission tomography.
PG  - 514-520
LID - 10.1111/psyg.12699 [doi]
AB  - BACKGROUND: Alzheimer's disease (AD) has a high incidence in the elderly. Besides 
      cognitive disorders, patients may also develop behavioural and psychological 
      symptoms of dementia (BPSD), which can be particularly disabling for patients and 
      families. BPSD encompass a wide range of symptoms, among which psychotic symptoms 
      and disruptive behaviours often prompt the first related hospitalization and 
      request for family support. The aetiological mechanism of BPSD has not yet been 
      clarified, and no predictive or risk factors have been identified. The main 
      objectives of our study are to describe the frequency of aggression/agitation and 
      psychotic symptoms, defined 'positive BPSD', in a cohort of 60 AD patients, 
      identify areas of the brain involved in behavioural symptomatology through brain 
      (18) F-fluorodesoxyglucose-positron emission tomography (FDG-PET), and 
      investigate a potential predictive role of brain FDG-PET in BPSD development. 
      METHODS: A cohort of 60 AD patients was retrospectively enrolled and regularly 
      followed for at least 3 years. Each subject underwent brain FDG-PET at the time 
      of diagnosis. Patients were divided into three groups based on the presence of 
      behavioural disturbances: present, absent, and developed later. RESULTS: Of the 
      60 AD patients in the cohort, 52% had positive BPSD: 17 at baseline and 14 during 
      the 3-year follow-up. FDG-PET identified an association between hypometabolism in 
      the bilateral temporal lobes and the presence of BPSD, and showed initial 
      hypometabolism in the postero-temporal lobes 3 years before symptom onset. 
      CONCLUSIONS: Positive BPSD are frequently manifested in AD. Our study identified 
      the temporal lobes as the neurobiological substrate of positive BPSD and FDG-PET 
      as a potential instument to predict their developement. Temporal lobes are 
      involved in processing facial expression and recognizing emotions; an impairment 
      of these functions could cause delusions and agitated/aggressive behaviour. To 
      confirm the potential predictive role of FDG-PET in the onset of BPSD in AD, 
      further studies are needed.
CI  - (c) 2021 Japanese Psychogeriatric Society.
FAU - Cappelletto, Pietro
AU  - Cappelletto P
AUID- ORCID: 0000-0002-8421-4799
AD  - Department of Pediatric Neurology Unit and Laboratories, A. Meyer Children's 
      Hospital, University of Florence, Florence, Italy.
FAU - Polito, Cristina
AU  - Polito C
AD  - Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", 
      Nuclear Medicine Unit, University of Florence, Florence, Italy.
FAU - Berti, Valentina
AU  - Berti V
AD  - Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", 
      Nuclear Medicine Unit, University of Florence, Florence, Italy.
FAU - Lombardi, Gemma
AU  - Lombardi G
AD  - IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.
FAU - Lucidi, Giulia
AU  - Lucidi G
AD  - IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.
AD  - Department of Neuroscience, Psychology, Drug Research and Child Health 
      (NEUROFARBA), University of Florence, Florence, Italy.
FAU - Bessi, Valentina
AU  - Bessi V
AD  - Department of Neuroscience, Psychology, Drug Research and Child Health 
      (NEUROFARBA), University of Florence, Florence, Italy.
FAU - Sorbi, Sandro
AU  - Sorbi S
AD  - IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.
AD  - Department of Neuroscience, Psychology, Drug Research and Child Health 
      (NEUROFARBA), University of Florence, Florence, Italy.
FAU - Ferrari, Camilla
AU  - Ferrari C
AD  - Department of Neuroscience, Psychology, Drug Research and Child Health 
      (NEUROFARBA), University of Florence, Florence, Italy.
LA  - eng
PT  - Journal Article
DEP - 20210421
PL  - England
TA  - Psychogeriatrics
JT  - Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
JID - 101230058
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Aged
MH  - *Alzheimer Disease
MH  - Brain
MH  - Fluorodeoxyglucose F18
MH  - Humans
MH  - Positron-Emission Tomography
MH  - *Problem Behavior
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - BPSD
OT  - brain FDG-PET
OT  - dementia.
EDAT- 2021/04/22 06:00
MHDA- 2021/07/06 06:00
CRDT- 2021/04/21 08:55
PHST- 2021/03/30 00:00 [revised]
PHST- 2020/09/21 00:00 [received]
PHST- 2021/04/05 00:00 [accepted]
PHST- 2021/04/22 06:00 [pubmed]
PHST- 2021/07/06 06:00 [medline]
PHST- 2021/04/21 08:55 [entrez]
AID - 10.1111/psyg.12699 [doi]
PST - ppublish
SO  - Psychogeriatrics. 2021 Jul;21(4):514-520. doi: 10.1111/psyg.12699. Epub 2021 Apr 
      21.