PMID- 33881362
OWN - NLM
STAT- MEDLINE
DCOM- 20210728
LR  - 20210728
IS  - 1522-1490 (Electronic)
IS  - 0363-6119 (Linking)
VI  - 320
IP  - 6
DP  - 2021 Jun 1
TI  - Transient effects of forebrain ischemia on fetal heart rate variability in fetal 
      sheep.
PG  - R916-R924
LID - 10.1152/ajpregu.00032.2021 [doi]
AB  - Fetal heart rate variability (FHRV) is a key index of antenatal and intrapartum 
      fetal well-being. FHRV is well established to be mediated by both arms of the 
      autonomic nervous system, but it remains unknown whether higher centers in the 
      forebrain contribute to FHRV. We tested the hypothesis that selective forebrain 
      ischemia would impair the generation of FHRV. Sixteen chronically instrumented 
      near-term fetal sheep were subjected to either forebrain ischemia induced by 
      bilateral carotid occlusion or sham-ischemia for 30 min. Time, frequency, and 
      nonlinear measures of FHRV were assessed during and for seven days after 
      ischemia. Ischemia was associated with profound suppression of 
      electroencephalographic (EEG) power, which remained suppressed throughout the 
      recovery period (P < 0.001). During the first 5 min of ischemia, multiple time 
      and frequency domain measures were increased (all P < 0.05) before returning back 
      to sham levels. A delayed increase in sample entropy was observed during ischemia 
      (P < 0.05). For the first 3 h after ischemia, there was moderate suppression of 
      two measures of FHRV (very-low frequency power and the standard deviation of 
      RR-intervals, both P < 0.05) and increased sample entropy (P < 0.05). Thereafter, 
      all measures of FHRV returned to control levels. In conclusion, profound 
      forebrain ischemia sufficient to lead to severe neural injury had only transient 
      effect on multiple measures of FHRV. These findings suggest that the forebrain 
      makes a limited contribution to FHRV. FHRV therefore primarily originates in the 
      hindbrain and is unlikely to provide meaningful information on forebrain 
      neurodevelopment or metabolism.
FAU - Maeda, Yoshiki
AU  - Maeda Y
AD  - Fetal Physiology and Neuroscience Group, Department of Physiology, The University 
      of Auckland, Auckland, New Zealand.
AD  - The Department of Obstetrics and Gynaecology, Mie University, Mie, Japan.
FAU - Lear, Christopher A
AU  - Lear CA
AUID- ORCID: 0000-0002-8937-0846
AD  - Fetal Physiology and Neuroscience Group, Department of Physiology, The University 
      of Auckland, Auckland, New Zealand.
FAU - Beacom, Michael J
AU  - Beacom MJ
AD  - Fetal Physiology and Neuroscience Group, Department of Physiology, The University 
      of Auckland, Auckland, New Zealand.
FAU - Davidson, Joanne O
AU  - Davidson JO
AD  - Fetal Physiology and Neuroscience Group, Department of Physiology, The University 
      of Auckland, Auckland, New Zealand.
FAU - Zhou, Kelly Q
AU  - Zhou KQ
AD  - Fetal Physiology and Neuroscience Group, Department of Physiology, The University 
      of Auckland, Auckland, New Zealand.
FAU - Gunning, Mark
AU  - Gunning M
AD  - Fetal Physiology and Neuroscience Group, Department of Physiology, The University 
      of Auckland, Auckland, New Zealand.
FAU - Ikeda, Tomoaki
AU  - Ikeda T
AUID- ORCID: 0000-0003-1489-4810
AD  - The Department of Obstetrics and Gynaecology, Mie University, Mie, Japan.
FAU - Gunn, Alistair J
AU  - Gunn AJ
AUID- ORCID: 0000-0003-0656-7035
AD  - Fetal Physiology and Neuroscience Group, Department of Physiology, The University 
      of Auckland, Auckland, New Zealand.
FAU - Bennet, Laura
AU  - Bennet L
AD  - Fetal Physiology and Neuroscience Group, Department of Physiology, The University 
      of Auckland, Auckland, New Zealand.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210421
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
SB  - IM
MH  - Animals
MH  - Autonomic Nervous System/physiopathology
MH  - Fetus/physiology/*physiopathology
MH  - Heart Rate/physiology
MH  - Heart Rate, Fetal/*drug effects/physiology
MH  - Humans
MH  - Ischemia/*physiopathology
MH  - Prenatal Care/methods
MH  - Sheep/*physiology
OTO - NOTNLM
OT  - fetal heart rate variability
OT  - fetus
OT  - ischemia
OT  - peripheral chemoreflex
EDAT- 2021/04/22 06:00
MHDA- 2021/07/29 06:00
CRDT- 2021/04/21 12:11
PHST- 2021/04/22 06:00 [pubmed]
PHST- 2021/07/29 06:00 [medline]
PHST- 2021/04/21 12:11 [entrez]
AID - 10.1152/ajpregu.00032.2021 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2021 Jun 1;320(6):R916-R924. doi: 
      10.1152/ajpregu.00032.2021. Epub 2021 Apr 21.