PMID- 33882027
OWN - NLM
STAT- MEDLINE
DCOM- 20210729
LR  - 20210729
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 13
IP  - 7
DP  - 2021 Mar 19
TI  - LncRNA MNX1-AS1 drives aggressive laryngeal squamous cell carcinoma progression 
      and serves as a ceRNA to target FoxM1 by sponging microRNA-370.
PG  - 9900-9910
LID - 10.18632/aging.202746 [doi]
AB  - Long non-coding RNA (LncRNA) MNX1 antisense RNA 1(MNX1-AS1) is associated with 
      the pathology of numerous cancers. But, the role and underlying pathways of 
      MNX1-AS1 in the regulation of laryngeal squamous cell carcinoma (LSCC) is not 
      known. We demonstrated remarkably elevated levels of MNX1-AS1 in the LSCC 
      tissues, which was correlated with poor disease prognosis. Moreover, 
      MNX1-AS1-silencing strongly suppressed LSCC cell proliferation, migration, and 
      invasion. We also demonstrated that MNX1-AS1 sequesters that activity of miR-370, 
      thereby releasing Forkhead Box ml (FoxM1) from the inhibitory actions of 
      MNX1-AS1. Furthermore, the positive correlation of MNX1-AS1 and FoxM1 as well as 
      the converse correlation between miR-370 and MNX1-AS1 (or FoxM1) were revealed in 
      LSCC tissues using experiments. Based on rescue assays, FoxM1 overexpression or 
      miR-370 downregulation partially recovered the inhibitory effect of MNX1-AS1 
      silencing on LSCC cells. Moreover, knockdown of MNX1-AS1 retarded tumor growth in 
      nude mice model. In summary, these findings verified that MNX1-AS1 modulated LSCC 
      progression by competitively binding with miR-370 to regulate FoxM1.
FAU - Cui, Xiangyan
AU  - Cui X
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Hospital of Jilin 
      University, Changchun 130021, China.
FAU - Yu, Hong
AU  - Yu H
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Hospital of Jilin 
      University, Changchun 130021, China.
FAU - Yu, Tingting
AU  - Yu T
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Hospital of Jilin 
      University, Changchun 130021, China.
FAU - Xiao, Dong
AU  - Xiao D
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Hospital of Jilin 
      University, Changchun 130021, China.
FAU - Wang, Xin
AU  - Wang X
AD  - Department of Otolaryngology-Head and Neck Surgery, The First Hospital of Jilin 
      University, Changchun 130021, China.
LA  - eng
PT  - Journal Article
DEP - 20210319
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 0 (Forkhead Box Protein M1)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Animals
MH  - Carcinoma, Squamous Cell/genetics/*metabolism/pathology
MH  - Cell Movement/genetics
MH  - Cell Proliferation/genetics
MH  - Disease Progression
MH  - Female
MH  - Forkhead Box Protein M1/genetics/*metabolism
MH  - Gene Knockdown Techniques
MH  - Humans
MH  - Laryngeal Neoplasms/genetics/*metabolism/pathology
MH  - Male
MH  - Mice
MH  - Mice, Nude
MH  - MicroRNAs/genetics/*metabolism
MH  - Middle Aged
MH  - Neoplasm Invasiveness/genetics
MH  - RNA, Long Noncoding/genetics/*metabolism
PMC - PMC8064170
OTO - NOTNLM
OT  - FoxM1
OT  - MNX1-AS1
OT  - laryngeal squamous cell carcinoma
OT  - miR-370
COIS- CONFLICTS OF INTEREST: The authors declare that they have no conflicts of 
      interests.
EDAT- 2021/04/22 06:00
MHDA- 2021/07/30 06:00
PMCR- 2021/04/15
CRDT- 2021/04/21 17:16
PHST- 2020/11/02 00:00 [received]
PHST- 2021/02/09 00:00 [accepted]
PHST- 2021/04/21 17:16 [entrez]
PHST- 2021/04/22 06:00 [pubmed]
PHST- 2021/07/30 06:00 [medline]
PHST- 2021/04/15 00:00 [pmc-release]
AID - 202746 [pii]
AID - 10.18632/aging.202746 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2021 Mar 19;13(7):9900-9910. doi: 10.18632/aging.202746. Epub 
      2021 Mar 19.