PMID- 33882699
OWN - NLM
STAT- MEDLINE
DCOM- 20211112
LR  - 20211112
IS  - 1938-2723 (Electronic)
IS  - 1076-0296 (Print)
IS  - 1076-0296 (Linking)
VI  - 27
DP  - 2021 Jan-Dec
TI  - No Association of Homocysteine, Anticardiolipin Antibody, and Anti-beta2 
      Glycoprotein I Antibody With Portal Venous System Thrombosis in Liver Cirrhosis.
PG  - 10760296211010969
LID - 10.1177/10760296211010969 [doi]
LID - 10760296211010969
AB  - Portal venous system thrombosis (PVST), a common complication of liver cirrhosis, 
      is closely associated with thrombophilia. To explore the association of 
      homocysteine (Hcy), anticardiolipin antibody (aCL), and anti-beta2 glycoprotein I 
      antibody (abeta(2)GPI), which are possible thrombophilic factors, with PVST in liver 
      cirrhosis. Overall, 654 non-malignant patients (219 with and 435 without liver 
      cirrhosis) admitted between January 2016 and June 2020 were retrospectively 
      evaluated. Presence of PVST, degree of main portal vein (MPV) thrombosis, and 
      clinically significant PVST were identified. Hcy level, hyperhomocysteinemia 
      (HHcy), aCL positivity, and abeta(2)GPI positivity were compared according to the 
      presence of liver cirrhosis and PVST. Positive abeta(2)GPI was significantly more 
      frequent in patients with liver cirrhosis than those without, but Hcy level and 
      proportions of HHcy and positive aCL were not significantly different between 
      them. PVST could be evaluated in 136 cirrhotic patients. Hcy level [10.57 mumol/L 
      (2.71-56.82) versus 9.97 mumol/L (2.05-53.44); P = 0.796] and proportions of HHcy 
      [4/44 (9.1%) versus 13/81 (16.0%); P = 0.413] and positive aCL [1/23 (4.3%) 
      versus 10/52 (19.2%); P = 0.185] and abeta(2)GPI [9/23 (39.1%) versus 21/52 (40.4%); 
      P = 0.919] were not significantly different between cirrhotic patients with and 
      without PVST. There was still no significant association of Hcy level, HHcy, aCL, 
      or abeta(2)GPI with PVST based on Child-Pugh classification, MPV thrombosis >50%, 
      and clinically significant PVST. Hcy, aCL, and abeta(2)GPI may not be associated 
      with PVST in liver cirrhosis, suggesting that routine screening for Hcy, aCL, and 
      abeta(2)GPI should be unnecessary in such patients.
FAU - Wang, Le
AU  - Wang L
AD  - Liver Cirrhosis Study Group, Department of Gastroenterology, 74643General 
      Hospital of Northern Theater Command (formerly called General Hospital of 
      Shenyang Military Area), Shenyang, China.
AD  - Postgraduate College, Dalian Medical University, Dalian, China.
FAU - Guo, Xiaozhong
AU  - Guo X
AD  - Liver Cirrhosis Study Group, Department of Gastroenterology, 74643General 
      Hospital of Northern Theater Command (formerly called General Hospital of 
      Shenyang Military Area), Shenyang, China.
FAU - Xu, Xiangbo
AU  - Xu X
AD  - Liver Cirrhosis Study Group, Department of Gastroenterology, 74643General 
      Hospital of Northern Theater Command (formerly called General Hospital of 
      Shenyang Military Area), Shenyang, China.
FAU - Xu, Shixue
AU  - Xu S
AD  - Liver Cirrhosis Study Group, Department of Gastroenterology, 74643General 
      Hospital of Northern Theater Command (formerly called General Hospital of 
      Shenyang Military Area), Shenyang, China.
FAU - Han, Juqiang
AU  - Han J
AD  - Institute of Hepatology, PLA Army General Hospital, Beijing, China.
FAU - Wang, Ran
AU  - Wang R
AUID- ORCID: 0000-0001-6137-9980
AD  - Liver Cirrhosis Study Group, Department of Gastroenterology, 74643General 
      Hospital of Northern Theater Command (formerly called General Hospital of 
      Shenyang Military Area), Shenyang, China.
FAU - Guo, Zeqi
AU  - Guo Z
AD  - Liver Cirrhosis Study Group, Department of Gastroenterology, 74643General 
      Hospital of Northern Theater Command (formerly called General Hospital of 
      Shenyang Military Area), Shenyang, China.
FAU - Yi, Fangfang
AU  - Yi F
AD  - Liver Cirrhosis Study Group, Department of Gastroenterology, 74643General 
      Hospital of Northern Theater Command (formerly called General Hospital of 
      Shenyang Military Area), Shenyang, China.
AD  - Postgraduate College, Dalian Medical University, Dalian, China.
FAU - Qi, Xingshun
AU  - Qi X
AUID- ORCID: 0000-0002-9448-6739
AD  - Liver Cirrhosis Study Group, Department of Gastroenterology, 74643General 
      Hospital of Northern Theater Command (formerly called General Hospital of 
      Shenyang Military Area), Shenyang, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Appl Thromb Hemost
JT  - Clinical and applied thrombosis/hemostasis : official journal of the 
      International Academy of Clinical and Applied Thrombosis/Hemostasis
JID - 9508125
RN  - 0 (Antibodies, Anticardiolipin)
RN  - 0 (beta 2-Glycoprotein I)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Anticardiolipin/*metabolism
MH  - Homocysteine/*metabolism
MH  - Humans
MH  - Liver Cirrhosis/*blood
MH  - Middle Aged
MH  - Venous Thrombosis/*blood
MH  - Young Adult
MH  - beta 2-Glycoprotein I/*metabolism
PMC - PMC8072837
OTO - NOTNLM
OT  - anti-beta2 glycoprotein I antibody
OT  - anticardiolipin antibody
OT  - homocysteine
OT  - liver cirrhosis
OT  - portal vein
OT  - thrombosis
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2021/04/23 06:00
MHDA- 2021/11/16 06:00
PMCR- 2021/04/22
CRDT- 2021/04/22 05:29
PHST- 2021/04/22 05:29 [entrez]
PHST- 2021/04/23 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2021/04/22 00:00 [pmc-release]
AID - 10.1177_10760296211010969 [pii]
AID - 10.1177/10760296211010969 [doi]
PST - ppublish
SO  - Clin Appl Thromb Hemost. 2021 Jan-Dec;27:10760296211010969. doi: 
      10.1177/10760296211010969.