PMID- 33882731
OWN - NLM
STAT- MEDLINE
DCOM- 20211130
LR  - 20211130
IS  - 1744-8069 (Electronic)
IS  - 1744-8069 (Linking)
VI  - 17
DP  - 2021 Jan-Dec
TI  - Association of serotonin transporter-linked polymorphic region (5-HTTLPR) with 
      heat pain stimulation and postoperative pain in gastric cancer patients.
PG  - 17448069211006606
LID - 10.1177/17448069211006606 [doi]
LID - 17448069211006606
AB  - BACKGROUND: The aim of this study was to assess whether the genotype of the 
      serotonin transporter-linked polymorphic region (5-HTTLPR) in gastric cancer 
      patients is associated with postoperative pain and pain threshold. METHODS: We 
      conducted a prospective cohort study of 251 patients scheduled for gastrectomy 
      from May to September 2019. All patients enrolled in the study were asked to 
      complete the Hospital Anxiety and Depression Scale questionnaire. Heat pain 
      threshold (HPT), cold pain threshold (CPT) and Pressure pain threshold (PPT) were 
      measured for all participants one day prior to surgery. Blood samples were 
      collected for genetic testing. All patients were connected to a 
      patient-controlled intravenous analgesia (PCIA) pump at the end of the surgery. 
      After exclusion of 15 patients, the postoperative conditions of 236 patients were 
      recorded. RESULTS: Distribution of homozygous long (L/L), heterozygous (L/S), and 
      homozygous short (S/S) 5-HTTLPR genotypes among participants were 26 (11.0%), 91 
      (38.6%), and 119 (50.4%), respectively. Heat pain threshold (P = 0.038) and 
      Numerical rating scale (NRS) in the 1st postoperative 24 h (P = 0.026) were 
      significantly different between long (L/L) and short (S/S) genotype carriers. 
      CONCLUSIONS: In patients with gastric cancer, heat pain stimulation is associated 
      with 5-HTTLPR polymorphism, and postoperative pain may be related to 5-HTTLPR 
      polymorphism.
FAU - Yu, Ling
AU  - Yu L
AD  - Key Laboratory of Carcinogenesis and Translational Research (Ministry of 
      Education, Beijing), Department of Anesthesiology, Peking University Cancer 
      Hospital & Institute, Beijing, China.
FAU - Li, Shuo
AU  - Li S
AD  - Key Laboratory of Carcinogenesis and Translational Research (Ministry of 
      Education, Beijing), Department of Anesthesiology, Peking University Cancer 
      Hospital & Institute, Beijing, China.
FAU - Wei, Jin
AU  - Wei J
AD  - Key Laboratory of Carcinogenesis and Translational Research (Ministry of 
      Education, Beijing), Department of Anesthesiology, Peking University Cancer 
      Hospital & Institute, Beijing, China.
FAU - Sun, Hongwei
AU  - Sun H
AD  - Key Laboratory of Carcinogenesis and Translational Research (Ministry of 
      Education, Beijing), Department of Anesthesiology, Peking University Cancer 
      Hospital & Institute, Beijing, China.
FAU - Yang, Caixia
AU  - Yang C
AD  - Key Laboratory of Carcinogenesis and Translational Research (Ministry of 
      Education, Beijing), Department of Anesthesiology, Peking University Cancer 
      Hospital & Institute, Beijing, China.
FAU - Tan, Hongyu
AU  - Tan H
AUID- ORCID: 0000-0002-8721-5068
AD  - Key Laboratory of Carcinogenesis and Translational Research (Ministry of 
      Education, Beijing), Department of Anesthesiology, Peking University Cancer 
      Hospital & Institute, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Pain
JT  - Molecular pain
JID - 101242662
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Cold Temperature
MH  - Female
MH  - Gastrectomy/*adverse effects
MH  - Genotype
MH  - Hot Temperature
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement
MH  - Pain Threshold/*physiology
MH  - Pain, Postoperative/etiology/*genetics/physiopathology
MH  - Polymorphism, Single Nucleotide
MH  - Pressure
MH  - Prospective Studies
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
MH  - Stomach Neoplasms/*genetics/surgery
PMC - PMC8071976
OTO - NOTNLM
OT  - Serotonin transporter gene
OT  - gastric cancer
OT  - pain threshold
OT  - postoperative pain
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2021/04/23 06:00
MHDA- 2021/12/01 06:00
PMCR- 2021/04/21
CRDT- 2021/04/22 05:30
PHST- 2021/04/22 05:30 [entrez]
PHST- 2021/04/23 06:00 [pubmed]
PHST- 2021/12/01 06:00 [medline]
PHST- 2021/04/21 00:00 [pmc-release]
AID - 10.1177_17448069211006606 [pii]
AID - 10.1177/17448069211006606 [doi]
PST - ppublish
SO  - Mol Pain. 2021 Jan-Dec;17:17448069211006606. doi: 10.1177/17448069211006606.