PMID- 33883660 OWN - NLM STAT- MEDLINE DCOM- 20211112 LR - 20240401 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 11 IP - 1 DP - 2021 Apr 21 TI - Immunoglobulin E levels and pregnancy-induced hypertension: Japan Environment and Children's Study. PG - 8664 LID - 10.1038/s41598-021-88227-2 [doi] LID - 8664 AB - High serum immunoglobulin E (IgE) levels are associated with cardiovascular events. We aimed to evaluate the association between total IgE levels during the first trimester of pregnancy and pregnancy-induced hypertension (PIH) development in a large Japanese cohort. We analysed data pertaining to singleton primipara pregnancies recorded in the Japan Environment and Children's Study involving births from 2011 to 2014. Serum IgE levels were determined using the immunonephelometric technique. High serum IgE was defined as level >/= 170 IU/ml. Hypertensive disorders in pregnancy (HDP) were categorized into early onset (Eo) PIH (developed < 34 weeks) or late onset (Lo) PIH (developed >== 34 weeks). A multiple logistic regression model was used to estimate the risk of high serum IgE levels on PIH, Eo-PIH, and Lo-PIH. Overall, 32,518 participants were enrolled. The prevalence of total, Eo-, and Lo-PIH was 3.2%, 0.6%, and 2.3%, respectively. Patients with high serum IgE levels had an increased risk of Lo-HDP (adjusted odds ratio [aOR]:1.19, 95% confidence interval 1.01-1.40). No correlation was found with either PIH (total) or Eo-PIH. High serum IgE levels during the first trimester were associated with the risk of Lo-PIH. Our results could influence and shape further research regarding the pathogenesis of Lo hypertension. FAU - Kyozuka, Hyo AU - Kyozuka H AD - Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. kyozuka@fmu.ac.jp. AD - Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. kyozuka@fmu.ac.jp. FAU - Murata, Tsuyoshi AU - Murata T AD - Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Fukuda, Toma AU - Fukuda T AD - Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Endo, Yuta AU - Endo Y AD - Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Yamaguchi, Akiko AU - Yamaguchi A AD - Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Yasuda, Shun AU - Yasuda S AD - Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Kanno, Aya AU - Kanno A AD - Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Sato, Akiko AU - Sato A AD - Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Ogata, Yuka AU - Ogata Y AD - Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Hosoya, Mitsuaki AU - Hosoya M AD - Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Yasumura, Seiji AU - Yasumura S AD - Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Department of Public Health, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Hashimoto, Koichi AU - Hashimoto K AD - Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Nishigori, Hidekazu AU - Nishigori H AD - Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Fukushima Medical Center for Children and Women, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Fujimori, Keiya AU - Fujimori K AD - Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Fukushima Regional Center for the Japan Environmental and Children's Study, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. CN - Japan Environment and Children's Study (JECS) Group LA - eng PT - Journal Article DEP - 20210421 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Hypertension, Pregnancy-Induced/*blood/epidemiology/etiology/immunology MH - Immunoglobulin E/*blood MH - Japan/epidemiology MH - Logistic Models MH - Pregnancy MH - Prevalence MH - Risk Factors MH - Young Adult PMC - PMC8060415 COIS- The authors declare no competing interests. FIR - Kamijima, Michihiro IR - Kamijima M FIR - Yamazaki, Shin IR - Yamazaki S FIR - Ohya, Yukihiro IR - Ohya Y FIR - Kishi, Reiko IR - Kishi R FIR - Yaegashi, Nobuo IR - Yaegashi N FIR - Mori, Chisato IR - Mori C FIR - Ito, Shuichi IR - Ito S FIR - Yamagata, Zentaro IR - Yamagata Z FIR - Inadera, Hidekuni IR - Inadera H FIR - Nakayama, Takeo IR - Nakayama T FIR - Iso, Hiroyasu IR - Iso H FIR - Shima, Masayuki IR - Shima M FIR - Kurozawa, Youichi IR - Kurozawa Y FIR - Suganuma, Narufumi IR - Suganuma N FIR - Kusuhara, Koichi IR - Kusuhara K FIR - Katoh, Takahiko IR - Katoh T EDAT- 2021/04/23 06:00 MHDA- 2021/11/16 06:00 PMCR- 2021/04/21 CRDT- 2021/04/22 06:31 PHST- 2020/12/05 00:00 [received] PHST- 2021/04/09 00:00 [accepted] PHST- 2021/04/22 06:31 [entrez] PHST- 2021/04/23 06:00 [pubmed] PHST- 2021/11/16 06:00 [medline] PHST- 2021/04/21 00:00 [pmc-release] AID - 10.1038/s41598-021-88227-2 [pii] AID - 88227 [pii] AID - 10.1038/s41598-021-88227-2 [doi] PST - epublish SO - Sci Rep. 2021 Apr 21;11(1):8664. doi: 10.1038/s41598-021-88227-2.