PMID- 33883916
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220422
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 14
DP  - 2021
TI  - The Involvement of Selenium in Type 2 Diabetes Development Related to Obesity and 
      Low Grade Inflammation.
PG  - 1669-1680
LID - 10.2147/DMSO.S303146 [doi]
AB  - BACKGROUND: Effects of the micronutrient selenium have been proposed in obesity 
      and type 2 diabetes mellitus (T2DM) that involve impairments in glucose metabolic 
      pathways and the insulin signaling cascade, mediated through oxidative stress and 
      inflammation. However, the evidence collected to date through animal and 
      epidemiologic studies has been inconclusive. Therefore, in the present study, we 
      aimed to evaluate the relationships of selenium status and inflammation with T2DM 
      and obesity. METHODS: Participants in the re-survey of the Electricity Generating 
      Authority of Thailand (EGAT)2 study conducted in 2013 (N=655, age 45-60 years) 
      were allocated to three groups based on their body mass index (World Health 
      Organization Asia-Pacific Classification), and their serum selenium and 
      high-sensitivity C-reactive protein (hs-CRP) concentrations and other clinical 
      parameters were compared. RESULTS: Significant differences in serum selenium and 
      hs-CRP among the groups were associated with differences in fasting blood glucose 
      and glycated hemoglobin, as well as differences in the prevalence of prediabetes 
      or T2DM. The adjusted odds ratios (ORs) (95% confidence intervals) for 
      prediabetes or diabetes were 1.991 (1.318-3.009) and 3.786 (2.087-6.896) for the 
      lowest and highest tertiles of serum selenium concentration in the entire sample 
      and obese participants, respectively. Furthermore, the rising extent of hs-CRP 
      increased the significantly associated with prediabetes or diabetes (adjusted 
      ORs; 2.268 for the entire sample, 4.043 for the overweight and 1.910 for the 
      obesity). CONCLUSION: Selenium status may be linked to both obesity and T2DM 
      through its effects on signaling pathways. Further nutrigenomic studies are 
      required to clarify the relationship between selenium and metabolic diseases.
CI  - (c) 2021 Wongdokmai et al.
FAU - Wongdokmai, Rossukon
AU  - Wongdokmai R
AD  - Doctoral Program in Nutrition, Faculty of Medicine Ramathibodi Hospital and 
      Institute of Nutrition, Mahidol University, Bangkok, Thailand.
FAU - Shantavasinkul, Prapimporn Chattranukulchai
AU  - Shantavasinkul PC
AD  - Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol 
      University, Bangkok, Thailand.
FAU - Chanprasertyothin, Suwannee
AU  - Chanprasertyothin S
AD  - Research & Innovation, Faculty of Medicine Ramathibodi Hospital, Mahidol 
      University, Bangkok, Thailand.
FAU - Panpunuan, Pachara
AU  - Panpunuan P
AD  - Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol 
      University, Bangkok, Thailand.
FAU - Matchariyakul, Dujrudee
AU  - Matchariyakul D
AD  - Health Office, Electricity Generating Authority of Thailand, Bangkok, Thailand.
FAU - Sritara, Piyamitr
AU  - Sritara P
AD  - Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol 
      University, Bangkok, Thailand.
FAU - Sirivarasai, Jintana
AU  - Sirivarasai J
AD  - Graduate Program in Nutrition, Faculty of Medicine, Ramathibodi Hospital, Mahidol 
      University, Bangkok, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20210414
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC8055366
OTO - NOTNLM
OT  - chronic inflammation
OT  - high sensitivity C-reactive protein
OT  - obesity
OT  - serum selenium
OT  - type 2 diabetes mellitus
COIS- The authors report no conflicts of interest associated with this work.
EDAT- 2021/04/23 06:00
MHDA- 2021/04/23 06:01
PMCR- 2021/04/14
CRDT- 2021/04/22 06:42
PHST- 2021/01/21 00:00 [received]
PHST- 2021/03/24 00:00 [accepted]
PHST- 2021/04/22 06:42 [entrez]
PHST- 2021/04/23 06:00 [pubmed]
PHST- 2021/04/23 06:01 [medline]
PHST- 2021/04/14 00:00 [pmc-release]
AID - 303146 [pii]
AID - 10.2147/DMSO.S303146 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2021 Apr 14;14:1669-1680. doi: 10.2147/DMSO.S303146. 
      eCollection 2021.