PMID- 33884946
OWN - NLM
STAT- MEDLINE
DCOM- 20210707
LR  - 20220423
IS  - 1943-4936 (Electronic)
IS  - 1040-6387 (Print)
IS  - 1040-6387 (Linking)
VI  - 33
IP  - 4
DP  - 2021 Jul
TI  - Tumor staging in a Beagle dog with concomitant large B-cell lymphoma and T-cell 
      acute lymphoblastic leukemia.
PG  - 792-796
LID - 10.1177/10406387211011024 [doi]
AB  - An 8-y-old spayed female Beagle dog was presented with peripheral 
      lymphadenomegaly. Lymph node cytology and flow cytometry led to the diagnosis of 
      large B-cell lymphoma (LBCL). We detected minimal percentages of LBCL cells in 
      peripheral blood and bone marrow samples. However, a monomorphic population of 
      neoplastic cells different from those found in the lymph node was found in the 
      bone marrow. T-cell acute lymphoblastic leukemia was suspected based on flow 
      cytometric immunophenotyping. PCR for antigen receptor rearrangement (PARR) 
      revealed clonal rearrangement of both B-cell and T-cell receptors, and the 
      presence of both neoplastic clones in the lymph node, peripheral blood, and bone 
      marrow. The dog was treated with multi-agent chemotherapy but died 46 d following 
      diagnosis. Tumor staging and patient classification are needed to accurately 
      establish a prognosis and select the most appropriate therapeutic protocol.
FAU - Ferrari, Alessandro
AU  - Ferrari A
AD  - Clinica Veterinaria San Lorenzo, Suisio, Bergamo, Italy.
FAU - Cozzi, Marzia
AU  - Cozzi M
AD  - Veterinary Teaching Hospital, Lodi, Italy.
FAU - Aresu, Luca
AU  - Aresu L
AD  - Department of Veterinary Sciences, University of Turin, Grugliasco, TO, Italy.
FAU - Martini, Valeria
AU  - Martini V
AUID- ORCID: 0000-0002-9882-2867
AD  - Department of Veterinary Medicine, University of Milan, Lodi, Italy.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20210422
PL  - United States
TA  - J Vet Diagn Invest
JT  - Journal of veterinary diagnostic investigation : official publication of the 
      American Association of Veterinary Laboratory Diagnosticians, Inc
JID - 9011490
RN  - 0 (Antineoplastic Agents)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/administration & dosage
MH  - Dog Diseases/*diagnosis/pathology
MH  - Dogs
MH  - Fatal Outcome
MH  - Female
MH  - Flow Cytometry/veterinary
MH  - Immunophenotyping/veterinary
MH  - Leukemia, T-Cell/diagnosis/pathology/*veterinary
MH  - Lymphoma, Large B-Cell, Diffuse/diagnosis/pathology/*veterinary
MH  - Neoplasm Staging/*veterinary
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis/pathology/*veterinary
MH  - Prognosis
PMC - PMC8229850
OTO - NOTNLM
OT  - Beagles
OT  - PARR
OT  - acute leukemia
OT  - flow cytometry
OT  - lymphoma
OT  - staging
COIS- Declaration of conflicting interests: The authors declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2021/04/23 06:00
MHDA- 2021/07/08 06:00
PMCR- 2022/04/22
CRDT- 2021/04/22 08:39
PHST- 2021/04/23 06:00 [pubmed]
PHST- 2021/07/08 06:00 [medline]
PHST- 2021/04/22 08:39 [entrez]
PHST- 2022/04/22 00:00 [pmc-release]
AID - 10.1177_10406387211011024 [pii]
AID - 10.1177/10406387211011024 [doi]
PST - ppublish
SO  - J Vet Diagn Invest. 2021 Jul;33(4):792-796. doi: 10.1177/10406387211011024. Epub 
      2021 Apr 22.