PMID- 33886810
OWN - NLM
STAT- MEDLINE
DCOM- 20210426
LR  - 20210429
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 54
IP  - 6
DP  - 2021
TI  - Dietary supplementation with whey protein improves systemic microvascular 
      function in heart failure patients: a pilot study.
PG  - e10577
LID - S0100-879X2021000600601 [pii]
LID - 10.1590/1414-431X202010577 [doi]
LID - e10577
AB  - Endothelial dysfunction is a well-known component of the pathophysiology of heart 
      failure (HF), with proven prognostic value. Dietary supplementation with whey 
      protein (WP) has been widely used to increase skeletal muscle mass, but it also 
      has vascular effects, which are less understood. This study aimed to evaluate the 
      effects of WP supplementation on the systemic microvascular function of HF 
      patients. This was a blinded, randomized, placebo-controlled clinical trial that 
      evaluated the effects of 12-week WP dietary supplementation on systemic 
      microvascular function, in patients with HF New York Heart Association (NYHA) 
      classes I/II. Cutaneous microvascular flow and reactivity were assessed using 
      laser speckle contrast imaging, coupled with pharmacological local vasodilator 
      stimuli. Fifteen patients (aged 64.5+/-6.2 years, 11 males) received WP 
      supplementation and ten patients (aged 68.2+/-8.8 years, 8 males) received placebo 
      (maltodextrin). The increase in endothelial-dependent microvascular vasodilation, 
      induced by skin iontophoresis of acetylcholine, was improved after WP (P=0.03) 
      but not placebo (P=0.37) supplementation. Moreover, endothelial-independent 
      microvascular vasodilation induced by skin iontophoresis of sodium nitroprusside, 
      was also enhanced after WP (P=0.04) but not placebo (P=0.42) supplementation. The 
      results suggested that dietary supplementation with WP improved systemic 
      microvascular function in patients with HF.
FAU - Lorenzo, A De
AU  - Lorenzo A
AUID- ORCID: 0000-0001-8522-6612
AD  - Instituto Nacional de Cardiologia, Rio de Janeiro, RJ, Brasil.
FAU - Santos, E M Dos
AU  - Santos EMD
AUID- ORCID: 0000-0002-6812-0936
AD  - Instituto Nacional de Cardiologia, Rio de Janeiro, RJ, Brasil.
FAU - Bello Moreira, A S
AU  - Bello Moreira AS
AUID- ORCID: 0000-0002-3263-613X
AD  - Instituto Nacional de Cardiologia, Rio de Janeiro, RJ, Brasil.
AD  - Departamento de Nutricao Social, Instituto de Nutricao, Universidade Estadual do 
      Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
FAU - Huguenin, G V B
AU  - Huguenin GVB
AUID- ORCID: 0000-0002-0553-4939
AD  - Instituto Nacional de Cardiologia, Rio de Janeiro, RJ, Brasil.
AD  - Departamento de Nutricao e Dietetica, Universidade Federal Fluminense, Niteroi, 
      RJ, Brasil.
FAU - Tibirica, E
AU  - Tibirica E
AUID- ORCID: 0000-0002-3406-9300
AD  - Instituto Nacional de Cardiologia, Rio de Janeiro, RJ, Brasil.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20210419
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Vasodilator Agents)
RN  - 0 (Whey Proteins)
SB  - IM
MH  - Aged
MH  - Dietary Supplements
MH  - Endothelium, Vascular
MH  - *Heart Failure/drug therapy
MH  - Humans
MH  - Male
MH  - Microcirculation
MH  - Middle Aged
MH  - Pilot Projects
MH  - Skin
MH  - *Vasodilation
MH  - Vasodilator Agents/pharmacology
MH  - Whey Proteins/pharmacology
PMC - PMC8055180
EDAT- 2021/04/23 06:00
MHDA- 2021/04/27 06:00
PMCR- 2021/04/19
CRDT- 2021/04/22 17:34
PHST- 2020/07/26 00:00 [received]
PHST- 2021/02/02 00:00 [accepted]
PHST- 2021/04/22 17:34 [entrez]
PHST- 2021/04/23 06:00 [pubmed]
PHST- 2021/04/27 06:00 [medline]
PHST- 2021/04/19 00:00 [pmc-release]
AID - S0100-879X2021000600601 [pii]
AID - 10.1590/1414-431X202010577 [doi]
PST - epublish
SO  - Braz J Med Biol Res. 2021 Apr 19;54(6):e10577. doi: 10.1590/1414-431X202010577. 
      eCollection 2021.