PMID- 33888647 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231103 IS - 1976-9148 (Print) IS - 2005-4483 (Electronic) IS - 1976-9148 (Linking) VI - 29 IP - 4 DP - 2021 Jul 1 TI - Diabetic Nephropathy - a Review of Risk Factors, Progression, Mechanism, and Dietary Management. PG - 365-372 LID - 10.4062/biomolther.2020.204 [doi] AB - Type 2 diabetes mellitus (T2DM) leads to many health problems like diabetic nephropathy (DN). One of the key factors for chronic kidney disease and end-stage renal disease (ESRD) is T2DM. Extensive work is being done to delineate the pathogenesis of DN and to extend possible remedies. This review is intended to understand the nature of DN risk factors, progression, effects of glycemic levels, and stages of DN. We also explored the novel diagnostic and therapeutic approaches for DN such as gene therapy and stem cell treatments. FAU - Natesan, Vijayakumar AU - Natesan V AD - Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608002, Tamilnadu, India. FAU - Kim, Sung-Jin AU - Kim SJ AD - Department of Pharmacology and Toxicology, Metabolic Diseases Research Laboratory, School of Dentistry, Kyung Hee University, Seoul 02447, Republic of Korea. LA - eng PT - Journal Article PT - Review PL - Korea (South) TA - Biomol Ther (Seoul) JT - Biomolecules & therapeutics JID - 101472832 PMC - PMC8255138 OTO - NOTNLM OT - Diabetic nephropathy OT - Hyperglycemia OT - Kidney disease OT - Novel drugs EDAT- 2021/04/24 06:00 MHDA- 2021/04/24 06:01 PMCR- 2021/04/23 CRDT- 2021/04/23 05:46 PHST- 2020/11/11 00:00 [received] PHST- 2021/01/18 00:00 [revised] PHST- 2021/03/26 00:00 [accepted] PHST- 2021/04/24 06:00 [pubmed] PHST- 2021/04/24 06:01 [medline] PHST- 2021/04/23 05:46 [entrez] PHST- 2021/04/23 00:00 [pmc-release] AID - biomolther.2020.204 [pii] AID - bt-29-4-365 [pii] AID - 10.4062/biomolther.2020.204 [doi] PST - ppublish SO - Biomol Ther (Seoul). 2021 Jul 1;29(4):365-372. doi: 10.4062/biomolther.2020.204.