PMID- 33889293
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210424
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 12
IP  - 4
DP  - 2021 Apr 15
TI  - Three-dimensional-arterial spin labeling perfusion correlation with 
      diabetes-associated cognitive dysfunction and vascular endothelial growth factor 
      in type 2 diabetes mellitus rat.
PG  - 499-513
LID - 10.4239/wjd.v12.i4.499 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) has been strongly associated with an 
      increased risk of developing cognitive dysfunction and dementia. The mechanisms 
      of diabetes-associated cognitive dysfunction (DACD) have not been fully 
      elucidated to date. Some studies proved lower cerebral blood flow (CBF) in the 
      hippocampus was associated with poor executive function and memory in T2DM. 
      Increasing evidence showed that diabetes leads to abnormal vascular endothelial 
      growth factor (VEGF) expression and CBF changes in humans and animal models. In 
      this study, we hypothesized that DACD was correlated with CBF alteration as 
      measured by three-dimensional (3D) arterial spin labeling (3D-ASL) and VEGF 
      expression in the hippocampus. AIM: To assess the correlation between CBF 
      (measured by 3D-ASL and VEGF expression) and DACD in a rat model of T2DM. 
      METHODS: Forty Sprague-Dawley male rats were divided into control and T2DM 
      groups. The T2DM group was established by feeding rats a high-fat diet and 
      glucose to induce impaired glucose tolerance and then injecting them with 
      streptozotocin to induce T2DM. Cognitive function was assessed using the Morris 
      water maze experiment. The CBF changes were measured by 3D-ASL magnetic resonance 
      imaging. VEGF expression was determined using immunofluorescence. RESULTS: The 
      escape latency time significantly reduced 15 wk after streptozotocin injection in 
      the T2DM group. The total distance traveled was longer in the T2DM group; also, 
      the platform was crossed fewer times. The percentage of distance in the target 
      zone significantly decreased. CBF decreased in the bilateral hippocampus in the 
      T2DM group. No difference was found between the right CBF value and the left CBF 
      value in the T2DM group. The VEGF expression level in the hippocampus was lower 
      in the T2DM group and correlated with the CBF value. The escape latency 
      negatively correlated with the CBF value. The number of rats crossing the 
      platform positively correlated with the CBF value. CONCLUSION: Low CBF in the 
      hippocampus and decreased VEGF expression might be crucial in DACD. CBF measured 
      by 3D-ASL might serve as a noninvasive imaging biomarker for cognitive impairment 
      associated with T2DM.
CI  - (c)The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Shao, Ju-Wei
AU  - Shao JW
AD  - Department of Radiology, The Second People's Hospital of Yunnan Province, The 
      Affiliated Hospital of Yunnan University, Kunming 650021, Yunnan Province, China.
FAU - Wang, Jin-De
AU  - Wang JD
AD  - College of Clinical Medicine, Kunming Medical University, Kunming 650500, Yunnan 
      Province, China.
FAU - He, Qian
AU  - He Q
AD  - Department of Radiology, The Second People's Hospital of Yunnan Province, The 
      Affiliated Hospital of Yunnan University, Kunming 650021, Yunnan Province, China.
FAU - Yang, Ying
AU  - Yang Y
AD  - Department of Endocrinology and Metabolism, The Second People's Hospital of 
      Yunnan Province, The Affiliated Hospital of Yunnan University, Kunming 650021, 
      Yunnan Province, China.
FAU - Zou, Ying-Ying
AU  - Zou YY
AD  - Department of Pathology and Pathophysiology, Kunming Medical University, Kunming 
      650021, Yunnan Province, China.
FAU - Su, Wei
AU  - Su W
AD  - Department of Radiology, The Second People's Hospital of Yunnan Province, The 
      Affiliated Hospital of Yunnan University, Kunming 650021, Yunnan Province, China.
FAU - Xiang, Shu-Tian
AU  - Xiang ST
AD  - Department of Radiology, The Second People's Hospital of Yunnan Province, The 
      Affiliated Hospital of Yunnan University, Kunming 650021, Yunnan Province, China.
FAU - Li, Jian-Bo
AU  - Li JB
AD  - Department of Radiology, The Second People's Hospital of Yunnan Province, The 
      Affiliated Hospital of Yunnan University, Kunming 650021, Yunnan Province, China.
FAU - Fang, Jing
AU  - Fang J
AD  - Institute for Health Sciences, Kunming Medical University, Kunming 650500, Yunnan 
      Province, China. fangjing07@126.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC8040076
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Diabetes-associated cognitive dysfunction
OT  - Hippocampus
OT  - Perfusion imaging
OT  - Receptors
OT  - Three-dimensional pseudo-continuous arterial spin labeling
OT  - Type 2
OT  - Vascular endothelial growth factor
COIS- Conflict-of-interest statement: No potential conflicts of interest.
EDAT- 2021/04/24 06:00
MHDA- 2021/04/24 06:01
PMCR- 2021/04/15
CRDT- 2021/04/23 06:25
PHST- 2020/12/11 00:00 [received]
PHST- 2021/01/12 00:00 [revised]
PHST- 2021/03/07 00:00 [accepted]
PHST- 2021/04/23 06:25 [entrez]
PHST- 2021/04/24 06:00 [pubmed]
PHST- 2021/04/24 06:01 [medline]
PHST- 2021/04/15 00:00 [pmc-release]
AID - 10.4239/wjd.v12.i4.499 [doi]
PST - ppublish
SO  - World J Diabetes. 2021 Apr 15;12(4):499-513. doi: 10.4239/wjd.v12.i4.499.