PMID- 33889609
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210424
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 9
IP  - 11
DP  - 2021 Apr 16
TI  - Impact of type 2 diabetes on adenoma detection in screening colonoscopies 
      performed in disparate populations.
PG  - 2433-2445
LID - 10.12998/wjcc.v9.i11.2433 [doi]
AB  - BACKGROUND: The Black/African Ancestry (AA) population has a higher prevalence of 
      type 2 diabetes mellitus (T2DM) and a higher incidence and mortality rate for 
      colorectal cancer (CRC) than all other races in the United States. T2DM has been 
      shown to increase adenoma risk in predominantly white/European ancestry (EA) 
      populations, but the effect of T2DM on adenoma risk in Black/AA individuals is 
      less clear. We hypothesize that T2DM has a significant effect on adenoma risk in 
      a predominantly Black/AA population. AIM: To investigate the effect of T2DM and 
      race on the adenoma detection rate (ADR) in screening colonoscopies in two 
      disparate populations. METHODS: A retrospective cohort study was conducted on ADR 
      during index screening colonoscopies (age 45-75) performed at an urban public 
      hospital serving a predominantly Black/AA population (92%) (2017-2018, n = 1606). 
      Clinical metadata collected included basic demographics, insurance, body mass 
      index (BMI), family history of CRC, smoking, diabetes diagnosis, and aspirin use. 
      This dataset was combined with a recently reported parallel retrospective cohort 
      data set collected at a suburban university hospital serving a predominantly 
      White/EA population (87%) (2012-2015, n = 2882). RESULTS: The ADR was higher in 
      T2DM patients than in patients without T2DM or prediabetes (35.2% vs 27.9%, P = 
      0.0166, n = 981) at the urban public hospital. Multivariable analysis of the 
      combined datasets showed that T2DM [odds ratio (OR) = 1.29, 95% confidence 
      interval (CI): 1.08-1.55, P = 0.0049], smoking (current vs never OR = 1.47, 
      95%CI: 1.18-1.82, current vs past OR = 1.32, 95%CI: 1.02-1.70, P = 0.0026), older 
      age (OR = 1.05 per year, 95%CI: 1.04-1.06, P < 0.0001), higher BMI (OR = 1.02 per 
      unit, 95%CI: 1.01-1.03, P = 0.0003), and male sex (OR = 1.87, 95%CI: 1.62-2.15, P 
      < 0.0001) were associated with increased ADR in the combined datasets, but race, 
      aspirin use and insurance were not. CONCLUSION: T2DM, but not race, is 
      significantly associated with increased ADR on index screening colonoscopy while 
      controlling for other factors.
CI  - (c)The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Joseph, Dimitri F
AU  - Joseph DF
AD  - Department of Medicine, Renaissance School of Medicine at Stony Brook University, 
      Stony Brook, NY 11794-8173, United States.
FAU - Li, Ellen
AU  - Li E
AD  - Department of Medicine, Division of Gastroenterology, Stony Brook University, 
      Stony Brook, NY 11794-8173, United States. ellen.li@stonybrookmedicine.edu.
FAU - Stanley Iii, Samuel L
AU  - Stanley Iii SL
AD  - Department of Applied Mathematics and Statistics, Stony Brook University, Stony 
      Brook, NY 11794-3600, United States.
FAU - Zhu, Yi-Cong
AU  - Zhu YC
AD  - Department of Applied Mathematics and Statistics, Stony Brook University, Stony 
      Brook, NY 11794-3600, United States.
FAU - Li, Xiao-Ning
AU  - Li XN
AD  - Department of Biostatistics and Bioinformatics Shared Resource, Stony Brook 
      Cancer Center, Stony Brook University, Stony Brook, NY 11794-3600, United States.
FAU - Yang, Jie
AU  - Yang J
AD  - Department of Applied Mathematics and Statistics, Stony Brook University, Stony 
      Brook, NY 11794-3600, United States.
FAU - Ottaviano, Lorenzo F
AU  - Ottaviano LF
AD  - Department of Medicine, Renaissance School of Medicine at Stony Brook University, 
      Stony Brook, NY 11794-8173, United States.
FAU - Bucobo, Juan Carlos
AU  - Bucobo JC
AD  - Department of Medicine, Renaissance School of Medicine at Stony Brook University, 
      Stony Brook, NY 11794-8173, United States.
FAU - Buscaglia, Jonathan M
AU  - Buscaglia JM
AD  - Department of Medicine, Renaissance School of Medicine at Stony Brook University, 
      Stony Brook, NY 11794-8173, United States.
FAU - Miller, Joshua D
AU  - Miller JD
AD  - Department of Medicine, Renaissance School of Medicine at Stony Brook University, 
      Stony Brook, NY 11794-8173, United States.
FAU - Veluvolu, Rajesh
AU  - Veluvolu R
AD  - Department of Medicine, NYC Health and Hospitals/Kings County, Brooklyn, NY 
      11203, United States.
FAU - Follen, Michele
AU  - Follen M
AD  - Department of Obstetrics and Gynecology, NYC Health and Hospitals/Kings County, 
      Brooklyn, NY 11203, United States.
FAU - Grossman, Evan B
AU  - Grossman EB
AD  - Department of Medicine, NYC Health and Hospitals/Kings County, Brooklyn, NY 
      11203, United States.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC8040183
OTO - NOTNLM
OT  - Adenoma
OT  - African continental ancestry group
OT  - Colonoscopy
OT  - Diabetes mellitus, type 2
OT  - European continental ancestry group
OT  - Multivariate analysis
COIS- Conflict-of-interest statement: The authors declare no competing interests.
EDAT- 2021/04/24 06:00
MHDA- 2021/04/24 06:01
PMCR- 2021/04/16
CRDT- 2021/04/23 06:29
PHST- 2020/12/05 00:00 [received]
PHST- 2020/12/23 00:00 [revised]
PHST- 2021/02/25 00:00 [accepted]
PHST- 2021/04/23 06:29 [entrez]
PHST- 2021/04/24 06:00 [pubmed]
PHST- 2021/04/24 06:01 [medline]
PHST- 2021/04/16 00:00 [pmc-release]
AID - 10.12998/wjcc.v9.i11.2433 [doi]
PST - ppublish
SO  - World J Clin Cases. 2021 Apr 16;9(11):2433-2445. doi: 10.12998/wjcc.v9.i11.2433.