PMID- 33891632
OWN - NLM
STAT- MEDLINE
DCOM- 20210929
LR  - 20210929
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 16
IP  - 4
DP  - 2021
TI  - Intraindividual variation of dose parameters in oncologic CT imaging.
PG  - e0250490
LID - 10.1371/journal.pone.0250490 [doi]
LID - e0250490
AB  - The objective of this study is to identify essential aspects influencing 
      radiation dose in computed tomography [CT] of the chest, abdomen and pelvis by 
      intraindividual comparison of imaging parameters and patient related factors. All 
      patients receiving at least two consecutive CT examinations for tumor staging or 
      follow-up within a period of 22 months were included in this retrospective study. 
      Different CT dose estimates (computed tomography dose index [CTDIvol], dose 
      length product [DLP], size-specific dose estimate [SSDE]) were correlated with 
      patient's body mass index [BMI], scan length and technical parameters (tube 
      current, tube voltage, pitch, noise level, level of iterative reconstruction). 
      Repeated-measures-analysis was initiated with focus on response variables 
      (CTDIvol, DLP, SSDE) and possible factors (age, BMI, noise, scan length, peak 
      kilovoltage [kVp], tube current, pitch, adaptive statistical iterative 
      reconstruction [ASIR]). A univariate-linear-mixed-model with 
      repeated-measures-analysis followed by Bonferroni adjustments was used to find 
      associations between CT imaging parameters, BMI and dose estimates followed by a 
      subsequent multivariate-mixed-model with repeated-measures-analysis with 
      Bonferroni adjustments for significant parameters. A p-value <0.05 was considered 
      statistically significant. We found all dose estimates in all imaging regions 
      were substantially affected by tube current. The iterative reconstruction 
      significantly influenced all dose estimates in the thoracoabdominopelvic scans as 
      well as DLP and SSDE in chest-CT. Pitch factor affected all dose parameters in 
      the thoracoabdominopelvic CT group. These results provide further evidence that 
      tube current has a pivotal role and potential in radiation dose management. The 
      use of iterative reconstruction algorithms can substantially decrease radiation 
      dose especially in thoracoabdominopelvic and chest-CT-scans. Pitch factor should 
      be kept at a level of >/=1.0 in order to reduce radiation dose.
FAU - Lange, Isabel
AU  - Lange I
AUID- ORCID: 0000-0002-4069-6634
AD  - Department of Diagnostic and Interventional Radiology, Hannover Medical School, 
      Hannover, Germany.
FAU - Alikhani, Babak
AU  - Alikhani B
AUID- ORCID: 0000-0001-8340-8535
AD  - Center for Radiology and Nuclear Medicine, Diakovere Henriettenstift, Hannover, 
      Germany.
FAU - Wacker, Frank
AU  - Wacker F
AD  - Department of Diagnostic and Interventional Radiology, Hannover Medical School, 
      Hannover, Germany.
FAU - Raatschen, Hans-Juergen
AU  - Raatschen HJ
AD  - Department of Diagnostic and Interventional Radiology, Hannover Medical School, 
      Hannover, Germany.
LA  - eng
PT  - Journal Article
DEP - 20210423
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Contrast Media)
SB  - IM
MH  - Abdomen/pathology/radiation effects
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Algorithms
MH  - Body Mass Index
MH  - Contrast Media/*administration & dosage/adverse effects
MH  - Diagnostic Tests, Routine
MH  - Dose-Response Relationship, Radiation
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Radiation-Induced/*epidemiology/pathology/prevention & control
MH  - Pelvis/diagnostic imaging/pathology/radiation effects
MH  - *Radiation Dosage
MH  - Radiographic Image Interpretation, Computer-Assisted/standards
MH  - Signal-To-Noise Ratio
MH  - Thorax/diagnostic imaging/radiation effects
MH  - Tomography, X-Ray Computed/*adverse effects
MH  - Young Adult
PMC - PMC8064522
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/04/24 06:00
MHDA- 2021/09/30 06:00
PMCR- 2021/04/23
CRDT- 2021/04/23 17:17
PHST- 2020/09/03 00:00 [received]
PHST- 2021/04/08 00:00 [accepted]
PHST- 2021/04/23 17:17 [entrez]
PHST- 2021/04/24 06:00 [pubmed]
PHST- 2021/09/30 06:00 [medline]
PHST- 2021/04/23 00:00 [pmc-release]
AID - PONE-D-20-27686 [pii]
AID - 10.1371/journal.pone.0250490 [doi]
PST - epublish
SO  - PLoS One. 2021 Apr 23;16(4):e0250490. doi: 10.1371/journal.pone.0250490. 
      eCollection 2021.