PMID- 33892067
OWN - NLM
STAT- MEDLINE
DCOM- 20211012
LR  - 20240226
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 275
DP  - 2021 Jul 15
TI  - Luffa operculata at a late period of gestation dysregulates melatonin and 
      cytokines interfering with weight of dams and their male offspring.
PG  - 113867
LID - S0378-8741(21)00093-3 [pii]
LID - 10.1016/j.jep.2021.113867 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: The tea made with the fruits of Luffa operculata 
      (L.) Cogn. (Cucurbitaceae; EBN) is popularly used as abortive. AIM OF THE STUDY: 
      The present work aimed at accessing how the exposition of female Wistar rats to 
      1.0 mg/kg of EBN (experimental group, EG), or distilled water (control group, 
      CG), by gavage, at gestational days (GD) 17-21 interfered with the reproductive 
      performance, and with dams' behavior after weaning. MATERIALS AND METHODS: At 
      post-natal day 2 (PND2), the number of male and female pups was evaluated, as 
      well as their weight. After weaning (PND21), dams were euthanized, and their 
      liver and kidneys were removed for histological and biochemical analyses, while 
      the blood was used in the evaluation of cytokines IL-1alpha, IL-1beta, IL-6 and TNF-alpha, 
      corticosterone, adrenocorticotrophic hormone, melatonin, AST, ALT and creatinine 
      levels. RESULTS AND DISCUSSION: Dams that were treated with EBN showed an 
      anxiety-like behavior, weight loss at the end of gestation and weight gain at 
      weaning, accompanied with a significant decrease in pro-inflammatory cytokines 
      and in the melatonin level. No significant histological or biochemical 
      alterations have occurred in the liver or kidneys. The number of female pups was 
      significantly higher in the EG. The male pups showed weight gain at PND60. 
      CONCLUSION: The presence of cucurbitacins is probably involved in the 
      dysregulations that were found, due to their polycyclic steroid triterpene 
      structure.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Alves, Cinthia Dos S
AU  - Alves CDS
AD  - Programa de Pos-Graduacao Em Patologia Ambiental e Experimental, Universidade 
      Paulista - UNIP, Brazil.
FAU - Frias, Humberto V
AU  - Frias HV
AD  - Programa de Pos-Graduacao Em Patologia Ambiental e Experimental, Universidade 
      Paulista - UNIP, Brazil.
FAU - Bonamin, Leoni V
AU  - Bonamin LV
AD  - Programa de Pos-Graduacao Em Patologia Ambiental e Experimental, Universidade 
      Paulista - UNIP, Brazil.
FAU - Correia, Michelle S F
AU  - Correia MSF
AD  - Programa de Pos-Graduacao Em Patologia Ambiental e Experimental, Universidade 
      Paulista - UNIP, Brazil.
FAU - Correa, Monica G
AU  - Correa MG
AD  - Programa de Pos-Graduacao Em Odontologia, Universidade Paulista - UNIP, Brazil.
FAU - Bondan, Eduardo F
AU  - Bondan EF
AD  - Programa de Pos-Graduacao Em Patologia Ambiental e Experimental, Universidade 
      Paulista - UNIP, Brazil.
FAU - de Fatima M Martins, Maria
AU  - de Fatima M Martins M
AD  - Departamento de Medicina Veterinaria, Universidade Cruzeiro Do Sul, Brazil.
FAU - Coelho, Cideli P
AU  - Coelho CP
AD  - Universidade Santo Amaro - UNISA, Brazil.
FAU - Bernardi, Maria M
AU  - Bernardi MM
AD  - Programa de Pos-Graduacao Em Patologia Ambiental e Experimental, Universidade 
      Paulista - UNIP, Brazil; Programa de Pos-Graduacao Em Odontologia, Universidade 
      Paulista - UNIP, Brazil.
FAU - Suffredini, Ivana B
AU  - Suffredini IB
AD  - Programa de Pos-Graduacao Em Patologia Ambiental e Experimental, Universidade 
      Paulista - UNIP, Brazil; Programa de Pos-Graduacao Em Odontologia, Universidade 
      Paulista - UNIP, Brazil; Nucleo de Pesquisas Em Biodiversidade, Laboratorio de 
      Extracao, Universidade Paulista - UNIP, Brazil. Electronic address: 
      ivana.suffredini@docente.unip.br.
LA  - eng
PT  - Journal Article
DEP - 20210421
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Cytokines)
RN  - 0 (Hormones)
RN  - 0 (Plant Extracts)
RN  - 60137-06-6 (Cucurbitacins)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - JL5DK93RCL (Melatonin)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Administration, Oral
MH  - Adrenocorticotropic Hormone/blood
MH  - Animals
MH  - Animals, Newborn
MH  - Behavior, Animal/drug effects
MH  - Body Weight/drug effects
MH  - Corticosterone/blood
MH  - Cucurbitacins/chemistry/pharmacology/toxicity
MH  - Cytokines/*blood
MH  - Female
MH  - Fruit/chemistry
MH  - Hormones/blood
MH  - Kidney/drug effects/pathology
MH  - Liver/drug effects
MH  - Luffa/*chemistry
MH  - Male
MH  - Maternal Exposure
MH  - Melatonin/*blood
MH  - Plant Extracts/administration & dosage/*pharmacology/toxicity
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Rats, Wistar
MH  - Reproduction/drug effects
MH  - Sex Characteristics
MH  - Rats
OTO - NOTNLM
OT  - Animal behavior
OT  - Buchinha-do-norte
OT  - Cognitive performance
OT  - Interleukines
OT  - Reproduction
OT  - Vertical treatment
EDAT- 2021/04/24 06:00
MHDA- 2021/10/13 06:00
CRDT- 2021/04/23 20:13
PHST- 2020/10/23 00:00 [received]
PHST- 2020/12/20 00:00 [revised]
PHST- 2021/01/18 00:00 [accepted]
PHST- 2021/04/24 06:00 [pubmed]
PHST- 2021/10/13 06:00 [medline]
PHST- 2021/04/23 20:13 [entrez]
AID - S0378-8741(21)00093-3 [pii]
AID - 10.1016/j.jep.2021.113867 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2021 Jul 15;275:113867. doi: 10.1016/j.jep.2021.113867. Epub 
      2021 Apr 21.