PMID- 33892086
OWN - NLM
STAT- MEDLINE
DCOM- 20211110
LR  - 20231115
IS  - 1878-5921 (Electronic)
IS  - 0895-4356 (Print)
IS  - 0895-4356 (Linking)
VI  - 137
DP  - 2021 Sep
TI  - Effective dose 50 method as the minimal clinically important difference: Evidence 
      from depression trials.
PG  - 200-208
LID - S0895-4356(21)00118-9 [pii]
LID - 10.1016/j.jclinepi.2021.04.002 [doi]
AB  - OBJECTIVE: Previous research on the minimal clinically important difference 
      (MCID) for depression and anxiety is based on population averages. The present 
      study aimed to identify the MCID across the spectrum of baseline severity. STUDY 
      DESIGN AND SETTINGS: The present analysis used secondary data from 2 randomized 
      controlled trials for depression (n = 1,122) to calibrate the Global Rating of 
      Change with the PHQ-9 and GAD-7. The MCID was defined as a change in scores 
      corresponding to a 50% probability of patients "feeling better", given their 
      baseline severity, referred to as Effective Dose 50 (ED50). RESULTS: MCID 
      estimates depended on baseline severity and ranged from no change for very mild 
      up to 14 points (52%) on the PHQ-9 and up to 10 points (48%) on the GAD-7 for 
      very high severity. The average MCID estimates were 3.7 points (23%) and 3.3 
      (28%) for the PHQ-9 and GAD-7 respectively. CONCLUSION: The ED50 method generates 
      MCID estimates across the spectrum of baseline severity, offering greater 
      precision but at the cost of greater complexity relative to population average 
      estimates. This has important implications for evaluations of treatments and 
      clinical practice where users can use these results to tailor the MCID to 
      specific populations according to baseline severities.
CI  - Copyright (c) 2021. Published by Elsevier Inc.
FAU - Bauer-Staeb, Clarissa
AU  - Bauer-Staeb C
AD  - Department of Psychology, University of Bath, Bath, United Kingdom.
FAU - Kounali, Daphne-Zacharenia
AU  - Kounali DZ
AD  - Bristol Medical School, University of Bristol, Bristol, United Kingdom.
FAU - Welton, Nicky J
AU  - Welton NJ
AD  - Bristol Medical School, University of Bristol, Bristol, United Kingdom.
FAU - Griffith, Emma
AU  - Griffith E
AD  - Department of Psychology, University of Bath, Bath, United Kingdom; Avon and 
      Wiltshire Mental Health Partnership NHS Trust, Bath, United Kingdom.
FAU - Wiles, Nicola J
AU  - Wiles NJ
AD  - Bristol Medical School, University of Bristol, Bristol, United Kingdom.
FAU - Lewis, Glyn
AU  - Lewis G
AD  - Division of Psychiatry, University College London, London, United Kingdom.
FAU - Faraway, Julian J
AU  - Faraway JJ
AD  - Department of Mathematical Sciences, University of Bath, Bath, United Kingdom.
FAU - Button, Katherine S
AU  - Button KS
AD  - Department of Psychology, University of Bath, Bath, United Kingdom. Electronic 
      address: k.s.button@bath.ac.uk.
LA  - eng
SI  - ISRCTN/ISRCTN84544741
SI  - ISRCTN/ISRCTN38231611
GR  - MR/K025643/1/MRC_/Medical Research Council/United Kingdom
GR  - MR/M005615/1/MRC_/Medical Research Council/United Kingdom
GR  - RP-PG-0610-10048/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210420
PL  - United States
TA  - J Clin Epidemiol
JT  - Journal of clinical epidemiology
JID - 8801383
SB  - IM
MH  - Adult
MH  - Anxiety/*drug therapy/therapy
MH  - Depression/*drug therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - Severity of Illness Index
PMC - PMC8485844
OTO - NOTNLM
OT  - Clinically Meaningful Change
OT  - GAD-7
OT  - MCID
OT  - Minimal Clinically Important Difference
OT  - PHQ-9
OT  - Primary Care
EDAT- 2021/04/24 06:00
MHDA- 2021/11/11 06:00
PMCR- 2021/09/01
CRDT- 2021/04/23 20:13
PHST- 2020/10/12 00:00 [received]
PHST- 2021/03/24 00:00 [revised]
PHST- 2021/04/13 00:00 [accepted]
PHST- 2021/04/24 06:00 [pubmed]
PHST- 2021/11/11 06:00 [medline]
PHST- 2021/04/23 20:13 [entrez]
PHST- 2021/09/01 00:00 [pmc-release]
AID - S0895-4356(21)00118-9 [pii]
AID - 10.1016/j.jclinepi.2021.04.002 [doi]
PST - ppublish
SO  - J Clin Epidemiol. 2021 Sep;137:200-208. doi: 10.1016/j.jclinepi.2021.04.002. Epub 
      2021 Apr 20.