PMID- 33892368
OWN - NLM
STAT- MEDLINE
DCOM- 20210615
LR  - 20210615
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 283
DP  - 2021 Aug 15
TI  - Association of exposures to perchlorate, nitrate, and thiocyanate with allergic 
      symptoms: A population-based nationwide cohort study.
PG  - 117068
LID - S0269-7491(21)00650-3 [pii]
LID - 10.1016/j.envpol.2021.117068 [doi]
AB  - Allergic diseases have been one of the leading causes of chronic disorders in the 
      United States. Animal studies have suggested that exposures to perchlorate, 
      nitrate, and thiocyanate could induce allergic inflammation. However, the 
      associations have not been examined among general populations. Here, we 
      investigated data of 7030 participants aged >/=6 years from the National Health and 
      Nutritional Examination Survey (NHANES) 2005-2006. Urinary levels of perchlorate, 
      nitrate, and thiocyanate were measured by ion chromatography combined with 
      electrospray tandem mass spectrometry. Information on allergic symptoms (hay 
      fever, allergy, rash, sneeze, wheeze, eczema, and current asthma) was collected 
      by questionnaire. Allergic sensitization was defined by a concentration >/=150 kU/L 
      for total immunoglobulin E (IgE) levels. The associations were estimated using 
      multivariate-adjusted logistic regression models. A positive association was 
      observed for urinary nitrate and eczema (p < 0.001 for the trend). Compared with 
      quartile 1 (lowest quartile), the odds ratios of eczema with 95% confidence 
      intervals [ORs (95% CIs)] from quartiles 2 to 4 were 1.72 (95% CI, 1.41, 2.09), 
      1.94 (1.53, 2.47) and 2.10 (1.49, 2.97) for urinary nitrate. In addition, urinary 
      thiocyanate was positively related to sneeze (OR(Q4 vs. Q1): 1.25, 95% CI: 1.01, 
      1.55; p = 0.015 for the trend). However, urinary perchlorate was not correlated 
      with any allergic-related outcome. Additionally, the associations were different 
      among subgroups in a four-level polytomous model. Thus, our results suggested 
      that exposures to nitrate and thiocyanate may be associated with allergic 
      symptoms. Further investigations are warranted to concentrate on the practical 
      strategies to monitor exposure levels and the latent mechanisms of the 
      relationship between exposure and allergy.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Zhu, Fanghuan
AU  - Zhu F
AD  - National Engineering Laboratory of Intelligent Food Technology and Equipment, 
      Zhejiang Key Laboratory for Agro-Food Processing, Fuli Institute of Food Science, 
      College of Biosystems Engineering and Food Science, Zhejiang University, 
      Hangzhou, Zhejiang, China.
FAU - Jiao, Jingjing
AU  - Jiao J
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Zhejiang 
      University School of Medicine, Hangzhou, Zhejiang, China.
FAU - Zhuang, Pan
AU  - Zhuang P
AD  - National Engineering Laboratory of Intelligent Food Technology and Equipment, 
      Zhejiang Key Laboratory for Agro-Food Processing, Fuli Institute of Food Science, 
      College of Biosystems Engineering and Food Science, Zhejiang University, 
      Hangzhou, Zhejiang, China.
FAU - Huang, Mengmeng
AU  - Huang M
AD  - National Engineering Laboratory of Intelligent Food Technology and Equipment, 
      Zhejiang Key Laboratory for Agro-Food Processing, Fuli Institute of Food Science, 
      College of Biosystems Engineering and Food Science, Zhejiang University, 
      Hangzhou, Zhejiang, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - National Engineering Laboratory of Intelligent Food Technology and Equipment, 
      Zhejiang Key Laboratory for Agro-Food Processing, Fuli Institute of Food Science, 
      College of Biosystems Engineering and Food Science, Zhejiang University, 
      Hangzhou, Zhejiang, China. Electronic address: y_zhang@zju.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210401
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Nitrates)
RN  - 0 (Perchlorates)
RN  - 0 (Thiocyanates)
SB  - IM
MH  - Animals
MH  - Cohort Studies
MH  - Nitrates
MH  - Nutrition Surveys
MH  - *Perchlorates
MH  - *Thiocyanates
MH  - United States
OTO - NOTNLM
OT  - Allergic symptoms
OT  - NHANES
OT  - Nitrate
OT  - Perchlorate
OT  - Thiocyanate
EDAT- 2021/04/24 06:00
MHDA- 2021/06/16 06:00
CRDT- 2021/04/23 20:24
PHST- 2020/12/20 00:00 [received]
PHST- 2021/03/05 00:00 [revised]
PHST- 2021/03/30 00:00 [accepted]
PHST- 2021/04/24 06:00 [pubmed]
PHST- 2021/06/16 06:00 [medline]
PHST- 2021/04/23 20:24 [entrez]
AID - S0269-7491(21)00650-3 [pii]
AID - 10.1016/j.envpol.2021.117068 [doi]
PST - ppublish
SO  - Environ Pollut. 2021 Aug 15;283:117068. doi: 10.1016/j.envpol.2021.117068. Epub 
      2021 Apr 1.