PMID- 33893004
OWN - NLM
STAT- MEDLINE
DCOM- 20210628
LR  - 20221207
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 31
IP  - 6
DP  - 2021 Jun 7
TI  - Neuronal Differentiation 1 gene Ala45Thr polymorphism and type 2 diabetes 
      mellitus: A meta-analysis of 7,940 subjects.
PG  - 1809-1821
LID - S0939-4753(21)00094-6 [pii]
LID - 10.1016/j.numecd.2021.02.023 [doi]
AB  - BACKGROUND AND AIMS: Previous studies have shown that there was a possible 
      relationship between human Neuronal Differentiation 1 (NEUROD1) gene Ala45Thr 
      polymorphism and type 2 diabetes mellitus (T2DM) susceptibility. Nevertheless, no 
      public opinion has been formed because of the conflicting results in the past 
      studies. In order to illuminate the potential association of human NEUROD1 gene 
      Ala45Thr polymorphism and T2DM, the present meta-analysis was conducted. METHODS 
      AND RESULTS: In the current meta-analysis, 7940 subjects from 14 individual 
      studies were included. The fixed or random effects models were used to evaluate 
      the pooled odds ratios (ORs) and their corresponding 95% confidence intervals 
      (CIs). The current meta-analysis found a significant association between NEUROD1 
      gene Ala45Thr polymorphism and T2DM under allelic (OR: 1.21, 95% CI: 1.04-1.41, 
      P = 0.01), dominant (OR: 0.819, 95% CI: 0.734-0.913, P = 3.31 x 10(-4)), 
      heterozygous (OR:1.199, 95% CI: 1.068-1.346, P = 0.002), and additive (OR: 1.33, 
      95% CI: 1.09-1.62, P = 0.004) genetic models. CONCLUSIONS: NEUROD1 gene Ala45Thr 
      polymorphism was significantly related to T2DM, especially in the Asian 
      population. More particularly, the Thr45 allele carriers of the NEUROD1 gene may 
      be more susceptible to T2DM.
CI  - Copyright (c) 2021 The Italian Diabetes Society, the Italian Society for the Study 
      of Atherosclerosis, the Italian Society of Human Nutrition and the Department of 
      Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. 
      All rights reserved.
FAU - Li, Yan-Yan
AU  - Li YY
AD  - Clinical Research Center, First Affiliated Hospital of Nanjing Medical 
      University, 300 Guangzhou Road, Nanjing, Jiangsu, 210029, China. Electronic 
      address: lyynjmu123@126.com.
FAU - Wang, Hui
AU  - Wang H
AD  - Department of Cardiology, First Affiliated Hospital of Nanjing Medical 
      University, 300 Guangzhou Road, Nanjing, Jiangsu, 210029, China.
FAU - Zhang, Yang-Yang
AU  - Zhang YY
AD  - Department of General Practice, First Affiliated Hospital of Nanjing Medical 
      University, 300 Guangzhou Road, Nanjing, Jiangsu, 210029, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210302
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (NEUROD1 protein, human)
SB  - IM
MH  - Asian People/genetics
MH  - Basic Helix-Loop-Helix Transcription Factors/*genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/diagnosis/ethnology/*genetics
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - *Polymorphism, Genetic
MH  - Risk Assessment
MH  - Risk Factors
OTO - NOTNLM
OT  - Ala45Thr
OT  - Genetic
OT  - NEUROD1
OT  - Polymorphism
OT  - Type 2 diabetes mellitus
COIS- Declaration of competing interest The authors have no other conflicts of interest 
      to disclose.
EDAT- 2021/04/25 06:00
MHDA- 2021/06/29 06:00
CRDT- 2021/04/24 05:36
PHST- 2020/12/01 00:00 [received]
PHST- 2021/02/19 00:00 [revised]
PHST- 2021/02/22 00:00 [accepted]
PHST- 2021/04/25 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2021/04/24 05:36 [entrez]
AID - S0939-4753(21)00094-6 [pii]
AID - 10.1016/j.numecd.2021.02.023 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2021 Jun 7;31(6):1809-1821. doi: 
      10.1016/j.numecd.2021.02.023. Epub 2021 Mar 2.