PMID- 33893768
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220415
IS  - 2148-5607 (Electronic)
IS  - 1300-4948 (Print)
IS  - 1300-4948 (Linking)
VI  - 32
IP  - 1
DP  - 2021 Jan
TI  - Gut Microbiota Characteristics in Children After the Use of Proton Pump 
      Inhibitors.
PG  - 70-75
LID - 10.5152/tjg.2020.20245 [doi]
AB  - BACKGROUND/AIMS: Prolonged acid suppression from proton pump inhibitor (PPI) has 
      been shown to cause gut microbiota alteration which may increase risk of various 
      infections in adults. We aimed to characterize gut microbiota profiles in 
      children after a short-term use of PPI. MATERIALS AND METHODS: Children aged 1-18 
      years who underwent PPI therapy were included during April-December 2017. We 
      excluded children who previously used antibiotics or acid suppressants, had a 
      history of acute gastroenteritis or specific food avoidance one month prior to 
      the enrolment. The stool samples before and after the PPI use were collected for 
      gut microbiota composition. The 16S ribosomal RNA gene sequencing was performed 
      by using Illumina MiSeq. The differences in gut microbiota profile after the use 
      of PPI were compared to pre-PPI period. RESULTS: We completed stool collection in 
      20 children (median age of 5.8 years and 60% were female). No significant changes 
      in the overall number of species-level taxonomy categories or predominant 
      bacteria phylum (Bacteroidetes) were noted. We found a trend increase in the 
      proportion of phylum Firmicutes among children living in the 
      metropolitan/suburban area (P=.07) and among males (P=.11). In four children with 
      infection-related adverse effects, we noted a non-significant increase in the 
      proportion of phylum Firmicutes after the PPI use (from 35 to 52%, P = .14). 
      CONCLUSION: Even the total number and predominant gut microbiota did not 
      significantly change after a four- to eight-week course of PPI therapy; we found 
      a trend of increased proportion of phylum Firmicutes in certain groups of 
      children.
FAU - Simakachorn, Lila
AU  - Simakachorn L
AD  - Division of Gastroenterology, Department of Pediatrics, Ramathibodi Hospital, 
      Mahidol University School of Medicine, Thailand.
FAU - Tanpowpong, Pornthep
AU  - Tanpowpong P
AD  - Division of Gastroenterology, Department of Pediatrics, Ramathibodi Hospital, 
      Mahidol University School of Medicine, Thailand.
FAU - Chanprasertyothin, Suwanee
AU  - Chanprasertyothin S
AD  - Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 
      Thailand.
FAU - Thongpradit, Supranee
AU  - Thongpradit S
AD  - Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 
      Thailand.
FAU - Treepongkaruna, Suporn
AU  - Treepongkaruna S
AD  - Division of Gastroenterology, Department of Pediatrics, Ramathibodi Hospital, 
      Mahidol University School of Medicine, Thailand.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - Turkey
TA  - Turk J Gastroenterol
JT  - The Turkish journal of gastroenterology : the official journal of Turkish Society 
      of Gastroenterology
JID - 9515841
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Digestive System Diseases/*drug therapy
MH  - Feces/microbiology
MH  - Female
MH  - *Gastrointestinal Microbiome/drug effects/genetics
MH  - Humans
MH  - Infant
MH  - Male
MH  - Prospective Studies
MH  - *Proton Pump Inhibitors/pharmacology/therapeutic use
PMC - PMC8975470
COIS- Conflict of Interest: The authors have no conflicts of interest to disclose.
EDAT- 2021/04/25 06:00
MHDA- 2022/02/01 06:00
PMCR- 2021/01/01
CRDT- 2021/04/24 12:04
PHST- 2021/04/24 12:04 [entrez]
PHST- 2021/04/25 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - tjg-32-1-70 [pii]
AID - 10.5152/tjg.2020.20245 [doi]
PST - ppublish
SO  - Turk J Gastroenterol. 2021 Jan;32(1):70-75. doi: 10.5152/tjg.2020.20245.