PMID- 33894214
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20240226
IS  - 1096-0333 (Electronic)
IS  - 0041-008X (Linking)
VI  - 421
DP  - 2021 Jun 15
TI  - Dose-dependent effects of prenatal exposure of pioglitazone, the PPARgamma agonist, 
      on the hippocampus development and learning and memory performance of rat 
      offspring.
PG  - 115544
LID - S0041-008X(21)00151-4 [pii]
LID - 10.1016/j.taap.2021.115544 [doi]
AB  - It is known that pioglitazone, defined as a PPARgamma agonist, has neuron-protective 
      properties in nervous system disorders. The aim of this study is to investigate 
      the effects of pioglitazone administration at different doses during prenatal 
      period on the neurons, glial cells and learning-memory levels in the hippocampus 
      of rat offspring. Pregnant rats were divided into three groups; Low-Dose 
      Pioglitazone (LDP), High-Dose Pioglitazone (HDP) and control (C) (n = 3). 
      Pregnant rats in the HDP and LDP groups were given pioglitazone at 30 mg/kg and 
      5 mg/kg doses, respectively, by gavage once a day during their pregnancy. No 
      procedure was applied to the rats in the control group. Morris water tank test 
      was applied to offspring obtained from postnatal 24th to 28th day. The offspring 
      were sacrificed on the 29th postal day and their brain tissues removed. 
      Stereological, histopathological and immunohistochemical techniques were used to 
      analyze brain tissues. As a result of the analysis, it was observed that there 
      were delays in learning and memory, the number of pyramidal neurons decreased, 
      and the density of cells stained with glial fibrillar acidic protein (GFAP) 
      positive increased in the HDP group compared to the other groups (p < 0.05). No 
      significant difference was found between the LDP and control groups in terms of 
      these parameters (p > 0.05). Our results showed that pioglitazone administered in 
      the prenatal period had an effect on the hippocampus development and learning and 
      memory performance of rats, depending on the dose.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Sagir, Dilek
AU  - Sagir D
AD  - Faculty of Health Sciences, Sinop University, 57000 Sinop, Turkey. Electronic 
      address: bio_dilek@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20210421
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (GFAP protein, rat)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (PPAR gamma)
RN  - 0 (PPAR gamma, rat)
RN  - X4OV71U42S (Pioglitazone)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Gestational Age
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Hippocampus/*drug effects/metabolism/physiopathology
MH  - Learning/*drug effects
MH  - Memory/drug effects
MH  - Morris Water Maze Test/drug effects
MH  - Neuroglia/drug effects/metabolism/pathology
MH  - PPAR gamma/*agonists/metabolism
MH  - Pioglitazone/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Pyramidal Cells/*drug effects/metabolism/pathology
MH  - Rats, Wistar
MH  - Rats
OTO - NOTNLM
OT  - Glial fibrillar acidic protein (GFAP)
OT  - Hippocampus
OT  - Learning and memory
OT  - Neurotoxicity
OT  - PPARgamma
OT  - Pioglitazone
EDAT- 2021/04/25 06:00
MHDA- 2021/06/22 06:00
CRDT- 2021/04/24 20:08
PHST- 2021/02/08 00:00 [received]
PHST- 2021/04/10 00:00 [revised]
PHST- 2021/04/19 00:00 [accepted]
PHST- 2021/04/25 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2021/04/24 20:08 [entrez]
AID - S0041-008X(21)00151-4 [pii]
AID - 10.1016/j.taap.2021.115544 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 2021 Jun 15;421:115544. doi: 10.1016/j.taap.2021.115544. 
      Epub 2021 Apr 21.