PMID- 33894442
OWN - NLM
STAT- MEDLINE
DCOM- 20211214
LR  - 20211214
IS  - 1532-3064 (Electronic)
IS  - 0954-6111 (Linking)
VI  - 182
DP  - 2021 Jun
TI  - Occult primary Sjogren Syndrome in patients with interstitial pneumonia with 
      autoimmune features.
PG  - 106405
LID - S0954-6111(21)00111-6 [pii]
LID - 10.1016/j.rmed.2021.106405 [doi]
AB  - INTRODUCTION/OBJECTIVES: To define the performance of Minor Salivary Gland Biopsy 
      (MSGB) and Dry Eye Tests (DET) to detect occult Sjogren Syndrome (SS) among 
      Interstitial Pneumonia with Autoimmune Features (IPAF) patients. METHODS: 
      Prospective study. Interstitial Lung Disease (ILD) patients without defined 
      Connective Tissue Disease and one or more IPAF classification domains or 
      xerophthalmia were included. MSGB, Schirmer's test (ST) and Ocular Staining Score 
      (OSS) were performed in a blinded manner by experienced specialists. MSGB with >/=1 
      focus of lymphocytes and Dry Eye Test (DET) with OSS >/= 5 and/or ST < 5 s were 
      considered positive. SS was diagnosed according to the ACR 2016 criteria. 
      RESULTS: 534 patients on the first consult were screened. 67 patients had at 
      least one IPAF criteria, 53 (79.1%) female, mean age (SD) 64.2 years old (10.8). 
      Positive ST in 36 (53.7%), positive OSS in 29 (43.3%) and positive MSGB in 36 
      (53.7%) were found. Finally, 27 (40.3%) met SS diagnostic criteria. 25 (37.3%) 
      and 18 (26.8%) of them did not report dry eyes or dry mouth, respectively. 53 
      (79.1%) had negative anti SSA/Ro, 57 (85.1%) had negative anti LA/SSB, 30 (44.7%) 
      had negative ANA, and 52 (77.6%) had negative RF, respectively. A significantly 
      higher proportion of ANA (+), anti-SSA/Ro (+), anti-SSB/La (+), positive DET and 
      positive MSGB were found in the SS population. CONCLUSIONS: A significant 
      proportion of patients with occult SS were found in our study. MSGB and DET may 
      be considered in the evaluation of IPAF patients.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Auteri, Santiago
AU  - Auteri S
AD  - Maria Ferrer Hospital, Interstitial Lung Disease Unit, Buenos Aires, Argentina.
FAU - Alberti, Maria L
AU  - Alberti ML
AD  - Maria Ferrer Hospital, Interstitial Lung Disease Unit, Buenos Aires, Argentina.
FAU - Fernandez, Martin E
AU  - Fernandez ME
AD  - Maria Ferrer Hospital, Interstitial Lung Disease Unit, Buenos Aires, Argentina.
FAU - Blanco, Guadalupe
AU  - Blanco G
AD  - Pedro Lagleyze Hospital, Buenos Aires, Argentina.
FAU - Raya, Mercedes
AU  - Raya M
AD  - Maria Ferrer Hospital, Interstitial Lung Disease Unit, Buenos Aires, Argentina.
FAU - Guman, Gabriela
AU  - Guman G
AD  - Maria Ferrer Hospital, Interstitial Lung Disease Unit, Buenos Aires, Argentina.
FAU - Garbarino, Maria C
AU  - Garbarino MC
AD  - Cosme Argerich Hospital, Buenos Aires, Argentina.
FAU - Carballo, Orlando Gabriel
AU  - Carballo OG
AD  - Carlos G. Durand Hospital, Buenos Aires, Argentina.
FAU - Caro, Fabian
AU  - Caro F
AD  - Maria Ferrer Hospital, Interstitial Lung Disease Unit, Buenos Aires, Argentina. 
      Electronic address: consultorioepidferrer@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20210420
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
SB  - IM
MH  - Aged
MH  - Autoimmunity
MH  - Biopsy
MH  - Diagnostic Techniques, Ophthalmological
MH  - Dry Eye Syndromes/diagnosis
MH  - Female
MH  - Humans
MH  - Lung Diseases, Interstitial/*etiology/immunology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Salivary Glands/pathology
MH  - Sjogren's Syndrome/complications/*diagnosis/pathology
OTO - NOTNLM
OT  - Interstitial pneumonia with autoimmune features
OT  - Minor salivary gland biopsy
OT  - Sjogren Syndrome
EDAT- 2021/04/25 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/04/24 20:12
PHST- 2020/12/28 00:00 [received]
PHST- 2021/03/26 00:00 [revised]
PHST- 2021/04/08 00:00 [accepted]
PHST- 2021/04/25 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/04/24 20:12 [entrez]
AID - S0954-6111(21)00111-6 [pii]
AID - 10.1016/j.rmed.2021.106405 [doi]
PST - ppublish
SO  - Respir Med. 2021 Jun;182:106405. doi: 10.1016/j.rmed.2021.106405. Epub 2021 Apr 
      20.