PMID- 33895144
OWN - NLM
STAT- MEDLINE
DCOM- 20210629
LR  - 20210629
IS  - 1873-6254 (Electronic)
IS  - 0001-706X (Linking)
VI  - 220
DP  - 2021 Aug
TI  - Immunoprotective inference of experimental chronic Trichinella spiralis infection 
      on house dust mites induced allergic airway remodeling.
PG  - 105934
LID - S0001-706X(21)00113-3 [pii]
LID - 10.1016/j.actatropica.2021.105934 [doi]
AB  - Allergic bronchial asthma is characterized by chronic inflammation of the 
      respiratory airways mediated by T-helper 2 (Th2), Th17 and their cytokines. 
      Although most asthmatic patients suffer from allergic airway remodeling (AAR), 
      aggressive anti-allergic treatment failed to reverse it. The hygiene hypothesis 
      illuminated the counter relationship between allergy and helminthic infections. 
      The immune system is modulated by Trichinella spiralis (T. spiralis) infection to 
      maintain homeostasis. Therefore, this work aimed to investigate the impact of 
      chronic T. spiralis infection on induced AAR in C57BL/6 mice sensitized by house 
      dust mites (HDM) allergens. Forty mice were divided into 3 groups: I (10 healthy 
      mice), IIota (15 HDM sensitized mice), and IotaIotaI (15 T. spiralis chronically infected 
      mice and sensitized with HDM allergens). The assessment aimed to evaluate the 
      effects of regulatory CD4+CD25+FOXP3+ cells (Tregs) and their cytokines 
      comparative to hypersensitivity mediated cytokines. Chronic T. spiralis infection 
      effectively prevented the host's AAR. This result was evidenced by upregulated 
      Tregs in blood by flow cytometric analysis and increased interleukin-10 (IL-10) 
      levels in bronchoalveolar lavage (BAL) by Enzyme linked immunosorbent assay 
      (ELISA) as well as improved lung histopathological changes. Also, serum HDM 
      specific immunoglobulin E (IgE), BAL eosinophils, BAL IL-5 levels, and IL-17 gene 
      expression in lung tissues were significantly reduced in T. spiralis chronically 
      infected mice. In conclusion, the immune response in chronic T. spiralis 
      infection could provide a promising mechanistic tool for protection against AAR, 
      which paves the way for innovative preventive measures of other immunological 
      disorders.
CI  - Published by Elsevier B.V.
FAU - Elmehy, Dalia A
AU  - Elmehy DA
AD  - Medical Parasitology Department, Faculty of Medicine, Tanta University, Tanta, 
      Egypt. Electronic address: dalia.elmehy@med.tanta.edu.eg.
FAU - Abdelhai, Dina I
AU  - Abdelhai DI
AD  - Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, 
      Egypt.
FAU - Elkholy, Rasha A
AU  - Elkholy RA
AD  - Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, 
      Egypt.
FAU - Elkelany, Maram M
AU  - Elkelany MM
AD  - Histology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
FAU - Tahoon, Dina M
AU  - Tahoon DM
AD  - Pharmacology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
FAU - Elkholy, Reem A
AU  - Elkholy RA
AD  - Pharmacology Department, Faculty of Medicine, Tanta University, Tanta, Egypt; 
      Pharmacology Department, School of Medicine, Badr University, Cairo, Egypt.
FAU - Soliman, Nema A
AU  - Soliman NA
AD  - Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, 
      Egypt.
FAU - Saad, Marwa A Hasby
AU  - Saad MAH
AD  - Medical Parasitology Department, Faculty of Medicine, Tanta University, Tanta, 
      Egypt.
FAU - El-Ebiary, Ahmad A
AU  - El-Ebiary AA
AD  - Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Tanta 
      University, Tanta, Egypt.
FAU - Gamea, Ghada A
AU  - Gamea GA
AD  - Medical Parasitology Department, Faculty of Medicine, Tanta University, Tanta, 
      Egypt.
LA  - eng
PT  - Journal Article
DEP - 20210423
PL  - Netherlands
TA  - Acta Trop
JT  - Acta tropica
JID - 0370374
RN  - 0 (Allergens)
RN  - 0 (Cytokines)
RN  - 0 (Interleukins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Airway Remodeling/*immunology
MH  - Allergens/immunology/pharmacology
MH  - Animals
MH  - Asthma/immunology
MH  - Bronchoalveolar Lavage Fluid/immunology
MH  - Cytokines/metabolism
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Inflammation/immunology
MH  - Interleukins/immunology
MH  - Lung/pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Pyroglyphidae/*immunology
MH  - T-Lymphocytes, Regulatory/immunology
MH  - Trichinella spiralis
MH  - Trichinellosis/*immunology
OTO - NOTNLM
OT  - Allergic airway remodeling
OT  - Bronchoalveolar lavage
OT  - CD4+CD25+FOXP3+ T cells
OT  - House dust mites
OT  - IgE
OT  - Trichinella spiralis
EDAT- 2021/04/26 06:00
MHDA- 2021/06/30 06:00
CRDT- 2021/04/25 20:28
PHST- 2021/01/06 00:00 [received]
PHST- 2021/04/03 00:00 [revised]
PHST- 2021/04/13 00:00 [accepted]
PHST- 2021/04/26 06:00 [pubmed]
PHST- 2021/06/30 06:00 [medline]
PHST- 2021/04/25 20:28 [entrez]
AID - S0001-706X(21)00113-3 [pii]
AID - 10.1016/j.actatropica.2021.105934 [doi]
PST - ppublish
SO  - Acta Trop. 2021 Aug;220:105934. doi: 10.1016/j.actatropica.2021.105934. Epub 2021 
      Apr 23.